Effects of catecholamine on gut immune systems.

• Project/Area Number: 25293367
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Keio University
• Principal Investigator: MORISAKI Hiroshi 慶應義塾大学, 医学部, 教授 (60182226)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Takeshi 慶應義塾大学, 医学部, 講師 (80327600)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000); Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: カテコラミン / 敗血症 / 腸内細菌 / 腸管免疫機構

Outline of Final Research Achievements

Although the present study demonstrated that high concentoration of norepinephrine stimulated bacterial proliferation of Escherichia coli and Staphylococcus epidermidis from clinical specimen, the concentrations of catecholamine in gut lumen were relatively low in sepsis. These datas suggest that endgenous catecholamine has little effects to modify intestinal badterial flora and gut immune systems.