How autophagy regulate periodontal bacterium
| Project/Area Number |
25293372
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Noda Takeshi 大阪大学, 歯学研究科(研究院), 教授 (00290908)
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| Co-Investigator(Kenkyū-buntansha) |
天野 敦雄 大阪大学, 歯学研究科(研究院), 教授 (50193024)
稲葉 裕明 大阪大学, 歯学研究科(研究院), 助教 (70359850)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | オートファジー / エンドサイトーシス / 歯周病 |
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| Outline of Final Research Achievements |
Periodondal disease is caused by excessive immunological reaction in epitheliumm, macrophage, and osteoclast in the gums and alveolar bone, which is caused by colonization of bacterium such as Porohyromonus gingibalis. In this study we revealed that Porohyromonus gingibalis invasion is associated with LYST mediated endocytosis.
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Report
(5 results)
Research Products
(16 results)
