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Functional role and regulatory mechanism of transcription factor Osterix in skeletal development

Research Project

Project/Area Number 25293378
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionOsaka University

Principal Investigator

Nishimura Riko  大阪大学, 歯学研究科(研究院), 教授 (60294112)

Co-Investigator(Renkei-kenkyūsha) HATA KENJI  大阪大学, 大学院歯学研究科, 准教授 (80444496)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords骨 / 軟骨 / 転写因子 / Osterix / エピゲノム
Outline of Final Research Achievements

Although Osterix is an essential transcription factor for membranous and endochondral ossification, Osterix knockout mice show both membranous and endochondral ossification at E18.5 days. We attempted to identify transcription factor that compensate osteogenic action of Osterix, and isolated a Sp1 family member transcription factor as a candidate. This Sp1 family member transcription factor was induced by BMP2 treatment. In addition, the Sp1 family member transcription factor showed similar function to Osterix in vitro. To understand the role of the Sp1 family member transcription factor in bone formation, we generated double knockout mice of Osterix and the Sp1 family member transcription factor, and examined the mice. The double knockout mice showed both membranous and endochondral ossification at E18.5 days. The data suggest that other molecule is involved in membranous and endochondral ossification.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (14 results)

All 2015 2014 2013

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification2015

    • Author(s)
      Yoshida M, Hata K, Takashima R, Ono K, Nakamura E, Takahata Y, Murakami T, Iseki S, Takano-Yamamoto T, Nishmura R, Yoneda T
    • Journal Title

      NATURE COMMUNICATIONS

      Volume: 6:6653 Issue: 1 Pages: 1-15

    • DOI

      10.1038/ncomms7653

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regulation of transcriptional network system during bone and cartilage development.2015

    • Author(s)
      Nishimura R, Hata K, Ikeda F, Matsubara T, Amano K, Ono K, Takigawa Y, Takashima R, Yoshida M, Nakamura E, Yoneda T.
    • Journal Title

      J Oral Bioscience

      Volume: 57 Pages: 165-170

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dlx5 and Mef2 Regulate a Novel Runx2 Enhancer for Osteoblast-Specific Expression.2014

    • Author(s)
      Kawane T, Komori H, Liu W, Moriishi T, Miyazaki T, Mori M, Matsuo Y, Takada Y, Izumi S, Jiang Q, Nishimura R, Kawai Y, Komori T.
    • Journal Title

      Journal of bone and mineral research

      Volume: - Issue: 9 Pages: 1960-1969

    • DOI

      10.1002/jbmr.2240

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indian Hedgehog Signaling Regulates Transcription and Expression of Collagen Type X via Runx2/Smads Interactions.2014

    • Author(s)
      Amano K, Densmore M, Nishimura R, Lanske B.
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 36 Pages: 24898-24910

    • DOI

      10.1074/jbc.m114.570507

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo.2013

    • Author(s)
      Kazuya Masuda, Barry Ripley, Riko Nishimura, Takashi Mino, Osamu Takeuchi, Go Shioi, Hiroshi Kiyonari, and Tadamitsu Kishimoto
    • Journal Title

      Proceeding of the National Academy of Sciences of the United States of America

      Volume: 110 Issue: 23 Pages: 9409-9414

    • DOI

      10.1073/pnas.1307419110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes2013

    • Author(s)
      Hata K, Takashima R, Amano K, Ono K, Nakanishi M, Yoshida M, Wakabayashi M, Matsuda A, Maeda Y, Suzuki Y, Sugano S, Whitson RH, Nishimura R and Yoneda T
    • Journal Title

      Nature communications

      Volume: 4 Issue: 1 Pages: 2850-2860

    • DOI

      10.1038/ncomms3850

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor initiating cell state.2013

    • Author(s)
      Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray M, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RGW, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG
    • Journal Title

      Cell Reports

      Volume: 6 Issue: 2 Pages: 1-12

    • DOI

      10.1016/j.celrep.2013.12.032

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨および軟骨の発生ならびに疾患における転写制御機構の変動.2013

    • Author(s)
      西村 理行、波多 賢二、高島 利加子、吉田 倫子、中村 恵理子、木田 淳平、八木 寛子
    • Journal Title

      Clinical Calcium

      Volume: 23 Pages: 1585-1593

    • Related Report
      2013 Annual Research Report
  • [Presentation] Regulation of endochondral ossification by transcription factors2015

    • Author(s)
      Nishimura R
    • Organizer
      International Symposium 2015 Oral and Craniofacial Development and Diseases
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 転写因子Foxc1はIhh-Gli2シグナルを促進し内軟骨性骨形成を制御する2015

    • Author(s)
      波多 賢二、吉田 倫子、中村 恵理子、高畑 佳史、村上 智彦、井関 祥子、山本 照子、西村 理行
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 転写因子Zfhx4はOsterixと結合して内軟骨性骨形成の後期過程を制御する2015

    • Author(s)
      中村 恵理子、波多 賢二、吉田 倫子、村上 智彦、高畑 佳史、阿部 真土、米田 俊之、西村 理行
    • Organizer
      第33回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル東京(東京都新宿区)
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 骨形成過程における転写制御プログラムの統合的理解の解明2014

    • Author(s)
      西村 理行
    • Organizer
      歯科基礎医学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Regulation of Endochondral Ossification by Transcription Factor2013

    • Author(s)
      Riko Nishimura
    • Organizer
      10th Bone Biology Forum
    • Place of Presentation
      富士教育研修所
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 転写ネットワークによる内軟骨性骨形成の制御機構2013

    • Author(s)
      西村 理行
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-21   Modified: 2019-07-29  

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