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Investigation of cancer therapeutic method without side effects: Suppression mechanisms of cancer metastasis on the lung by CXCL14/BRAK

Research Project

Project/Area Number 25293384
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKanagawa Dental College

Principal Investigator

Hata Ryu-Ichiro  神奈川歯科大学, 歯学研究科(研究院), その他 (10014276)

Co-Investigator(Kenkyū-buntansha) MAEHATA YOJIROU  神奈川歯科大学, 大学院歯学研究科, 講師 (80410009)
IZUKURI KAZUHITO  神奈川歯科大学, 大学院歯学研究科, 講師 (90257296)
AKASAKA TETSU  神奈川歯科大学, 大学院歯学研究科, 助教 (60316263)
MIYAMOTO CHIHIRO  神奈川歯科大学, 大学院歯学研究科, 特別研究員 (50633963)
Co-Investigator(Renkei-kenkyūsha) TAKEDA KAZUYOSHI  順天堂大学, 大学院医学研究科, 准教授 (80272821)
MUKAIDA NAOFUMI  金沢大学, がん伸展制御研究所, 教授 (30182067)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Keywords癌抑制分子 / ケモカイン / 転移抑制 / 副作用のない癌抑制法 / 余命の延長 / がん抑制分子 / 多段階がん抑制性ケモカイン / 多機能がん抑制性ケモカイン / ケモカインCXCL14 / CXCL14 / ケモカインCXCL14/BRAK / 発癌抑制 / 寿命の延長
Outline of Final Research Achievements

The main cause of Japanese death is due to the recurrence of cancer, and metastasis. We have previously reported that the rate of carcinogenesis, the growth of tumor transplants and metastasis in CXCL14 over-expressed transgenic (Tg) mouse were significantly lower compared with that for isogenic wild type C57BL/6 (Wt) mice. Here we investigated suppression mechanisms of metastasis by CXCL14 using the pulmonary metastasis system of the malignant melanoma cell and the cell culture system. It was found that CXCL14 and interferon-γ (IFN-γ) secreted by the activated natural killer (NK)T cells, and also IFN-γ secreted by activated natural killer cells synergistically suppressed the metastasis of the cells on the lungs.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (34 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (27 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results)

  • [Journal Article] Expression of the chemokine CXCL14 and cetuximab-dependent tumour suppression in head and neck squamous cell carcinoma2016

    • Author(s)
      Tadanori Kondo, Shigeyuki Ozawa, Takeharu Ikoma, Xiao-Yan Yang, Keisuke Kanamori, Kenji Suzuki, Hiroshi Iwabuchi, Yojio Maehata, Chihiro Miyamoto, Takahide Taguchi, Tohru Kiyono, Eiro Kubota, and Ryu-Ichiro Hata
    • Journal Title

      Oncogenesis

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Repression of Wnt/β-catenin response elements by p63 (TP63).2016

    • Author(s)
      Iyoko Katoh, Nahoko Fukunishi, Masahiro Fujimuro, Hirotake Kasai, Kohji Moriishi, Ryu-Ichiro Hata & Shun-ichi Kurata
    • Journal Title

      Cell Cycle

      Volume: 15 Pages: 699-710

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemokine CXCL14 is a multistep tumor suppressor.2016

    • Author(s)
      Xiao-Yan Yang, Chihiro Miyamoto, Tetsu Akasaka, Kazuhito Izukuri, Yojiro Maehata, Takeharu Ikoma, Shigeyuki Ozawa, Ryu-Ichiro Hata
    • Journal Title

      Journal of Oral Biosciences

      Volume: 58 Issue: 1 Pages: 16-22

    • DOI

      10.1016/j.job.2015.08.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] がんに強いマウスを作る:がんの分子標的予防医学の開発に向けて.2015

    • Author(s)
      畑 隆一郎, 陽 暁艶, 宮本千央, 前畑洋次郎, 小澤重幸
    • Journal Title

      生化学

      Volume: 87 Pages: 591-596

    • NAID

      40020650165

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice.2015

    • Author(s)
      Hata R, Izukuri K, Kato Y, Sasaki S, Mukaida N, Maehata Y, Miyamoto C, Akasaka T, Yang X, Nagashima Y, Takeda K, Kiyono T, Taniguchi M.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 9083-9083

    • DOI

      10.1038/srep09083

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <b>Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell car</b><b>cinoma </b>2014

    • Author(s)
      Miyamoto C., Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Yoshino F, Yoshida A, Kubota E, Hata R, Lee M.C
    • Journal Title

      Biomedical Research

      Volume: 35 Issue: 6 Pages: 381-388

    • DOI

      10.2220/biomedres.35.381

    • NAID

      130004903867

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 再生医療、癌治療とビタミンC2013

    • Author(s)
      畑 隆一郎
    • Journal Title

      ビタミン

      Volume: 87 Pages: 639-641

    • Related Report
      2013 Annual Research Report
  • [Presentation] Rho Kinase (ROCK) Inhibitor Fasudil Suppresses Head and Neck Squamous Carcinoma Growth by Stimulating Gene Expression and Protein Secretion of the CXCL14/BRAK.2016

    • Author(s)
      Miyamoto C, Ozawa C, Ikoma T, Izukuri K, Hata R, Maehata Y.
    • Organizer
      The 13th Asia Pacific Federation of Pharmacologist (APFP) Meeting
    • Place of Presentation
      Bangkok
    • Year and Date
      2016-02-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Scavenger of reactive oxygen species is effective for the inhibition of angiogenesis and tumor proliferation in human head and neck squamous cell carcinoma cells by regulation gene expression of chemokines2016

    • Author(s)
      Yojiro Maehata, Chihiro Miyamoto, Fumihiko Yoshino, Shigeyuki Ozawa, Shun-suke Takahashi, Satoko Wada-Takahashi, Ayaka Yoshida, Kazuhito Izukuri Ryu-Ichiro Hata, Keiichi Tsukinoki
    • Organizer
      The 13th Asia Pacific Federation of Pharmacologist (APFP) Meeting, Bangkok
    • Place of Presentation
      Bangkok
    • Year and Date
      2016-02-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] p63(TP63)はTCF/βカテニンによる遺伝子発現誘導を制御する.2015

    • Author(s)
      倉田俊一、畑隆一郎、加藤伊陽子
    • Organizer
      第88回日本生化学会(第38回日本分子生物学会との共同開催)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] p63はTCF/βカテニンによる遺伝子発現を抑制する2015

    • Author(s)
      加藤伊陽子、畑隆一郎、倉田俊一
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] がんの肺転移抑制におけるケモカインBRAKとNKTとの相互作用.2015

    • Author(s)
      陽暁艶,宮本千央, 居作和人, 前畑洋次郎, 赤坂徹, 加藤靖正, 畑隆一郎
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] ケモカインCXCl14の発現がセツキシマブ(抗上皮増殖因子受容体抗体)の腫瘍抑制活性を決定する.2015

    • Author(s)
      生駒丈晴, 小澤重幸, 鈴木健司, 岩淵博史, 陽暁艶,宮本千央, 前畑洋次郎, 畑隆一郎
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] EXPRESSION OF THE CHEMOKINE CXCL14 IS A PREDICTIVE BIOMARKER FOR CETUXIMAB-DEPENDENT TUMOUR SUPPRESSION2015

    • Author(s)
      Ryu-Ichiro Hata, Tadanori Kondo, Shigeyuki Ozawa, Takeharu Ikoma, Kenji Suzuki, Hiroshi Iwabuchi, Yojiro Maehata, Chihiro Miyamoto, Xiaoyan Yang, Eiro Kubota
    • Organizer
      st Nature Immunology - Cellular & Molecular Immunology Joint Conference
    • Place of Presentation
      Hefei, China
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PRODUCTION OF CANCER RESISTANT MICE BY INTRODUCING CHEMOKINE CXCL14 GENE INTO THE WILD TYPE C57BL/6 (WT) MICE.2015

    • Author(s)
      Xiaoyan Yang, Kazuhito Izukuri, Yasumasa Kato, Soichiro Sasaki, Naofumi Mukaida, Yojiro Maehata, Chihiro Miyamoto, Tetsu Akasaka, Ryu-Ichiro Hata
    • Organizer
      1st Nature Immunology - Cellular & Molecular Immunology Joint Conference
    • Place of Presentation
      Hefei, Chi
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Synergistic effects of chemokine BRAK and NKT cells on the suppression of metastasis on the lung.2015

    • Author(s)
      Xiaoyan Yang, Chihiro Miyamoto、Kazuhito Izukuri, Tetsu Akasaka, Yojiro Maehata, Yasumasa Kato, Ryu-Ichiro Hata
    • Organizer
      第47回日本結合組織学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Chemokine CXCL14 is a multistep tumor suppressor.2015

    • Author(s)
      Ryu-Ichiro Hata, Kazuhito Izukuri, Yasumasa Kato, Soichiro Sasaki, Chihiro Miyamoto, Tetsu Akasaka, Xiaoyan Yang, Yojiro Maehata, Yoji Nagashima, Kazuyoshi Takeda, Tohru Kiyono, Naofumi Mukaida, Masaru Taniguchi
    • Organizer
      2015 American Association of Cancer Research Annual Meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      2015-04-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ケモカインCXCL14/BRAKは多段階癌抑制分子である:CXCL14/BRAKトランスジェニックマウスを用いた検討.2015

    • Author(s)
      陽暁艶, 宮本千央, 赤坂徹, 居作和人, 前畑洋次郎, 畑隆一郎
    • Organizer
      神奈川歯科大学学会 第 143回例会,
    • Place of Presentation
      横須賀
    • Year and Date
      2015-01-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌における抗腫瘍ケモカインCXCL14/BRAKの局在を標的とした新規多剤併用療法の研究開発.2015

    • Author(s)
      宮本千央, 生駒丈晴, 近藤忠雄, 小澤重幸, 畑隆一郎, 久保田英朗, 前畑洋次郎
    • Organizer
      神奈川歯科大学学会 第143回例会
    • Place of Presentation
      横須賀
    • Year and Date
      2015-01-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 癌に強いマウスの作成2014

    • Author(s)
      畑隆一郎
    • Organizer
      第87回日本生化学会フォーラム「治療医学から分子予防医学へ」
    • Place of Presentation
      京都
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 癌の分子標的治療から分子標的予防医学へ.2014

    • Author(s)
      畑隆一郎
    • Organizer
      第56回歯科基礎医学会学術大会シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] ROCK specific inhibitor fasudil suppresses head and neck squamous carcinoma growth by stimulating gene expression and protein secretion of the CXCL14/BRAK,2014

    • Author(s)
      Miyamoto C, Ozawa T, Ikoma T, Wada-Takahashi S, Takahashi S-S, Yoshida A, Yoshino F, Hata R, Lee M-C, Maehata Y,
    • Organizer
      FEBS-EMBO 2014 Conference,
    • Place of Presentation
      Paris, France
    • Year and Date
      2014-08-30 – 2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 再生医療におけるビタミンC誘導体の可能性.2014

    • Author(s)
      畑隆一郎
    • Organizer
      第160回FJセミナー「プロビタミンCの未来」
    • Place of Presentation
      東京
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 微小環境が発癌, 癌の進展を制御する:癌に強いマウスの作製.2014

    • Author(s)
      畑隆一郎, 居作和人, 加藤靖正, 前畑洋次郎, 宮本千央, 赤坂徹, 佐々木宗一郎, 向田直史
    • Organizer
      第46回日本結合組織学会学術大会&#8226;第61回マトリックス研究会大会合同学術大会
    • Place of Presentation
      横須賀
    • Year and Date
      2014-06-05 – 2014-06-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tumor-Suppressing Chemokine CXCL14/BRAK is a Cell-Surface Associated Matrix Component2013

    • Author(s)
      HataR.Izukuri K. Kato Y
    • Organizer
      9th Pan Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      Hong Kong
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Fasudil Suppresses Head and Neck Squamous Cell Carcinoma Growth by Stimulating Gene Expression and Secretion of the Chemokine CXCL14/BRAK2013

    • Author(s)
      Miyamoto C., Ozawa S., Takahashi S-S., W-Takahashi S., Yoshino F., Lee M-C., Hata R-I., Maehata Y.
    • Organizer
      Pharmacology 2013
    • Place of Presentation
      London, England,
    • Related Report
      2013 Annual Research Report
  • [Presentation] PubMedを過信してはいけない2013

    • Author(s)
      畑隆一郎, 居作和人, 加藤靖正
    • Organizer
      第45回日本結合組織学会 学術大会&#8226;第60回マトリックス研究会大会合同学術大会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌に強くなる遺伝子の 発見2013

    • Author(s)
      畑 隆一郎,居作 和人,加藤 靖正, 佐々木 宗一郎, 向田 直史
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ケモカインCXCL14/BRAKは多段階癌抑制分子である2013

    • Author(s)
      畑 隆一郎, 居作 和人, 加藤 靖正
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel mechanisms of Wnt/beta-catenin signal activation by p632013

    • Author(s)
      Kato I. Fukunishi N. Fujimuro M. Hata R. Kurata S
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] CXCL14/BRAK is a multifunctional tumor suppressor2013

    • Author(s)
      Hata R. Sasaki S. Kato Y. Mukaida N
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 再生医療、癌治療とビタミンC

    • Author(s)
      畑 隆一郎
    • Organizer
      日本ビタミン学会市民公開講座
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CXCL14のプロモーターのメチル化は頭頚部扁平上皮癌に対するセツキシマブの抗腫瘍効果に 関与する

    • Author(s)
      近藤忠雄, 小澤重幸, 生駒丈晴, 鈴木健司, 前畑洋次郎, 宮本千央, 畑隆一郎,久保田英朗
    • Organizer
      神奈川歯科大学学会第48回総会
    • Place of Presentation
      横須賀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌における ROCK 阻害剤による CXCL14/BRAK を介した抗腫瘍効果の検討

    • Author(s)
      宮本千央,生駒丈晴,小澤重幸,高橋俊介,高橋聡子,吉野文彦,吉田彩佳,畑隆一郎,李 昌一,前畑洋次郎
    • Organizer
      神奈川歯科大学学会 第 143 回例会
    • Place of Presentation
      横須賀
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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