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Development of a combination treatment of heat, UVA and cross linking for strengthening human dentin

Research Project

Project/Area Number 25293387
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionOsaka University

Principal Investigator

Hayashi Mikako  大阪大学, 歯学研究科(研究院), 教授 (40271027)

Co-Investigator(Kenkyū-buntansha) Iwami Yukiteru  大阪大学, 大学院歯学研究科, 招聘教員 (90303982)
古谷 優  大阪大学, 歯学部附属病院, 医員 (20635411)
Co-Investigator(Renkei-kenkyūsha) Minoshima Koji  大阪大学, 工学(系)研究科(研究院), 教授 (50174107)
Saito Mitsuru  東京慈恵会医科大学, 医学部, 准教授 (50301528)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords歯科保存学 / 象牙質 / コラーゲン / 機械的強度 / 紫外線 / 分子間架橋 / 保存修復学 / 機械的性質 / 架橋 / 歯学
Outline of Final Research Achievements

The effects of heating, UVA irradiation and cross linking on the mechanical strength of human dentin were comprehensively investigated. After the combination treatment of riboflavin and UVA irradiation, the flexural strength and fracture toughness were increased 2.2 and 1.4 times higher than those before the treatment. Since the surface temperature of the dentin after the riboflavin and UVA treatment raised up to 45 C, this treatment can be considered as the combination of heat, UVA, and cross linker. The strengthening mechanisms of dentin by this combination treatment can be the short-term excited radical reaction at hydroxy proline induced by the UVA irradiation.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (40 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (3 results) Journal Article (15 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 15 results,  Acknowledgement Compliant: 7 results,  Open Access: 2 results) Presentation (18 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Book (3 results) Funded Workshop (1 results)

  • [Int'l Joint Research] 台湾国立大学(台湾)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] ミネソタ大学(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] 第四医科大学(中国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Comprehensive analyses of how tubule occlusion and advanced glycation end-products diminish strength of aged dentin2016

    • Author(s)
      Shinno Y, Ishimoto T, Saito M, Uemura R, Arino M, Marumo K, Nakano T, Hayashi M
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 19849-19849

    • DOI

      10.1038/srep19849

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Multicenter study on caries risk assessment in Japanese adult patients.2015

    • Author(s)
      Arino M, Ito A, Fujiki S, Sugiyama S, Hayashi M
    • Journal Title

      J Dent

      Volume: 43 Issue: 10 Pages: 1223-1228

    • DOI

      10.1016/j.jdent.2015.07.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The use of a fiber sleeve to improve fracture strength of pulpless teeth with flared root canals.2015

    • Author(s)
      Xiong Y, Huang SH, Shinno Y, Furuya Y, Imazato S, Fok A, Hayashi M
    • Journal Title

      Dental Materials

      Volume: 31 Pages: 1427-1434

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evaluation of caries progression in dentin treated by fluoride-containing materials using an in-air micro-PIGE and micro-PIXE measurement system.2015

    • Author(s)
      Yamamoto H*, Iwami Y, Yagi K, Hayashi M, Komatsu H, Okuyama K, Matsuda Y, Yasuda K
    • Journal Title

      Nucl Instrum Meth B

      Volume: 348 Pages: 152-155

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effectiveness of non-biodegradable poly(2-hydroxyethyl methacrylate)-based hydrogel particles as a fibroblast growth factor-2 releasing carrier.2015

    • Author(s)
      Takeda K, Kitagawa H, Tsuboi R, Kiba W, Sasaki JI, Hayashi M, Imazato S
    • Journal Title

      Dental Materials

      Volume: 31 Issue: 11 Pages: 1406-1414

    • DOI

      10.1016/j.dental.2015.09.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fracture strength and stress distributions of pulpless premolars restored with fiber posts.2014

    • Author(s)
      Furuya Y, Huang SH, Takeda Y, Fok A, Hayashi M.
    • Journal Title

      Dent Mater J.

      Volume: 33 Pages: 852-858

    • NAID

      130004706448

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Promotion of endodontic lesions in rats by a novel extraradicular model using obturation materials2014

    • Author(s)
      Kuremoto K. Noiri Y. Ishimoto T. Yoneda N. Yamamoto R. Maezono H. Nakano T. Hayashi M. Ebisu S
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 80 Issue: 13 Pages: 3804-3810

    • DOI

      10.1128/aem.00421-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dentistry in the 21st century: challenges of a globalising world.2014

    • Author(s)
      Hayashi M, Haapasalo M, Imazato S, Lee JI, Momoi Y, Murakami S, Whelton H, Wilson N.
    • Journal Title

      Int Dent J.

      Volume: 64 Issue: 6 Pages: 333-342

    • DOI

      10.1111/idj.12132

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of sustained antimicrobial-release systems using poly(2-hydroxyethyl methacrylate)/trimethylolpropane trimethacrylate hydrogels.2014

    • Author(s)
      Kitagawa H, Takeda K, Kitagawa R, Izutani N, Miki S, Hirose N, Hayashi M, Imazato S.
    • Journal Title

      Acta Biomater.

      Volume: 10 Issue: 10 Pages: 4285-4295

    • DOI

      10.1016/j.actbio.2014.06.016

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an antibacterial root canal filling system containing MDPB.2014

    • Author(s)
      Kitagawa R, Kitagawa H, Izutani N, Hirose N, Hayashi M, Imazato S.
    • Journal Title

      J Dent Res.

      Volume: 93 Issue: 12 Pages: 1277-1282

    • DOI

      10.1177/0022034514549808

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of dentinal microcracks using infrared thermography2013

    • Author(s)
      Matsusita-Tokugawa M
    • Journal Title

      Journal of Endodontics

      Volume: 39 Issue: 1 Pages: 88-91

    • DOI

      10.1016/j.joen.2012.06.033

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validity of a portable microhardness testing system (Cariotester) for diagnosis of progression in active caries lesions2013

    • Author(s)
      Iwami Y, Yamamoto H, Hayashi M
    • Journal Title

      Dental Materials Journal

      Volume: 32 Pages: 667-672

    • NAID

      10031178653

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Porphyromonas gingivalis biofilms persist after chlorhexidine treatment2013

    • Author(s)
      Yamaguchi M, Noiri Y, Kuboniwa M, Yamamoto R, Asahi Y, Maezono H, Hayashi M, Ebisu S
    • Journal Title

      Eur J Oral Sci

      Volume: Vol.121 Issue: 3pt1 Pages: 162-8

    • DOI

      10.1111/eos.12050

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The sinR ortholog PGN_0088 encodes a transcriptional regulator that inhibits polysaccharide synthesis in Porphyromonas gingivalis ATCC 33277 biofilms2013

    • Author(s)
      Yamamoto R, Noiri Y, Yamaguchi M, Asahi Y, Maezono H, Kuboniwa M, Hayashi M, Ebisu S
    • Journal Title

      PLoS One

      Volume: Vol.8, No.2 Issue: 2 Pages: e56017-e56017

    • DOI

      10.1371/journal.pone.0056017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of the Wnt/β-catenin pathway and tissue inhibitor of metalloprotease 1 during tertiary dentinogenesis2013

    • Author(s)
      Yoshioka S
    • Journal Title

      Journal of Biochemistry

      Volume: 153 Issue: 1 Pages: 43-50

    • DOI

      10.1093/jb/mvs117

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Antibacterial effects of self-adhesive resin cements containing chlorhexidine。2015

    • Author(s)
      Kitagawa R, Kitagawa H, Hirose N, Yamaguchi S, Mehdawi IM, Hayashi M, Imazato S
    • Organizer
      Academy of Dental Materials Annual Meeting 2015
    • Place of Presentation
      Hawaii (USA)
    • Year and Date
      2015-10-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Caries risk assessment in adults using Survival Analysis Classification and Regression Trees.2015

    • Author(s)
      Arino M, Ito A, Fujiki S, Sugiyama S, Hayashi M
    • Organizer
      62nd ORCA 2015
    • Place of Presentation
      Brussels (Belgium)
    • Year and Date
      2015-07-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 活性リボフラビンによるヒト象牙質の強化効果2015

    • Author(s)
      上村怜央、新野侑子、岡本基岐、高橋雄介、林 美加子
    • Organizer
      第142回日本歯科保存学会春季学術大会
    • Place of Presentation
      北九州市( 北九州国際会議場)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] In-air micro-beam PIXE/PIGEを用いた根面象牙質の脱灰評価2015

    • Author(s)
      八木香子、山本洋子、岩見行晃、林 美加子
    • Organizer
      第142回日本歯科保存学会春季学術大会
    • Place of Presentation
      北九州市( 北九州国際会議場)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Japan pioneering clinical Guideline treating dental caries.2015

    • Author(s)
      Hayashi M
    • Organizer
      10th International Dental Cokkaboration of the Mekong River Region
    • Place of Presentation
      Bangkok (Thailand)
    • Year and Date
      2015-06-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Quantitative Analysis of Human Dental Biofilms by New in situ Model2014

    • Author(s)
      Wake N, Asahi Y, Noiri Y, Machi H, Ebisu S, Hayashi M
    • Organizer
      62nd Annual Meeting of the Japanese Association for Dental Research
    • Place of Presentation
      Osaka
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] The analysis of a new mesenchymal population for neural stemness2014

    • Author(s)
      Yamauchi Y, Itoh S, Yamamoto Y, Matsushita K, Naruse H, Hayashi M
    • Organizer
      62nd Annual Meeting of the Japanese Association for Dental Research
    • Place of Presentation
      Osaka
    • Year and Date
      2014-12-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 赤外線サーモグラフィを用いた歯根破折診断法の検出限界2014

    • Author(s)
      松下真美、久保美寿穂、大谷直矢、三浦治郎、竹重文雄、阪上隆英、林 美加子
    • Organizer
      第141回日本歯科保存学会秋季学術大会
    • Place of Presentation
      山形
    • Year and Date
      2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] データマイニングの手法を用いたう蝕病変発生予測モデルの構築2014

    • Author(s)
      有野真澄、伊藤中、林 美加子
    • Organizer
      第140回日本歯科保存学会春季学術大会
    • Place of Presentation
      大津
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] S- PRGフィラー含有試作セメントの覆髄剤としての応用2014

    • Author(s)
      岡本基岐、高橋雄介、小道俊吾、林 美加子
    • Organizer
      第140回日本歯科保存学会春季学術大会
    • Place of Presentation
      大津
    • Year and Date
      2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Contributions of Microstructure and Composition to Mechanical Properties of Dentin2013

    • Author(s)
      Takeda Y, Furuya Y, Ishimoto T, Nakano T, Hayashi M.
    • Organizer
      The 9th World Endodontic Congress
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Time course micro-CT analysis of periapical lesions using an extraradicular biofilm model in rat2013

    • Author(s)
      Kuremoto K, Noiri Y, Ishimoto T, Yoneda N, Maezono H, T. Nakano M, Hayashi M, Ebisu S.
    • Organizer
      The 9th World Endodontic Congress
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mineral trioxide aggregate(MTA) for obturation of mandibular premolar and molar with open apices following unsuccessful apicoectomy: A case report2013

    • Author(s)
      Yabune T, Hayashi M.
    • Organizer
      The 9th World Endodontic Congress
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effectiveness of CT and MTA for endodontic surgery: A case report2013

    • Author(s)
      Furuya Y, Takeda Y, Noiri Y, Mikako Hayashi
    • Organizer
      The 9th World Endodontic Congress
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Investigation on factors causing refractory periapical periodontitis in general practices2013

    • Author(s)
      Yamaguchi M, Noiri Y, Ito Y, Komichi S, Hayashi M
    • Organizer
      The 9th World Endodontic Congress
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] Caries risk assessment in adults using Classification and Regression Tree2013

    • Author(s)
      Nagai M, Ito A, Hayashi M
    • Organizer
      The 60th Congress of the European Organisation for Caries Research
    • Place of Presentation
      Liverpool
    • Related Report
      2013 Annual Research Report
  • [Presentation] The time-specific effect of LIF on adipocyte differentiation2013

    • Author(s)
      Ikeda S, Itoh S, Matsushita K, Yamamoto Y, Yamauchi Y, Hayashi M.
    • Organizer
      2nd Meeting of the International Association for Dental Research - Asia Pacific Region
    • Place of Presentation
      Bangkok
    • Related Report
      2013 Annual Research Report
  • [Presentation] Role of PGN_0088 of Porphyromonas gingivalis Biofilm formation2013

    • Author(s)
      Yamamoto R, Noiri Y, Yamaguchi M, Asahi Y, Maezono H, Kuboniwa M, Hayashi M, Ebisu S.
    • Organizer
      2nd Meeting of the International Association for Dental Research - Asia Pacific Region
    • Place of Presentation
      Bangkok
    • Related Report
      2013 Annual Research Report
  • [Book] う蝕治療ガイドライン第2版2015

    • Author(s)
      林 美加子(分担執筆)日本歯科保存学会編
    • Total Pages
      129
    • Publisher
      永末書店
    • Related Report
      2015 Annual Research Report
  • [Book] 接着歯学 第2版2015

    • Author(s)
      北川蘭奈、林 美加子、今里 聡(分担執筆)
    • Total Pages
      186
    • Publisher
      医歯薬出版
    • Related Report
      2015 Annual Research Report
  • [Book] 削るう蝕削らないう蝕2013

    • Author(s)
      今里聡、林美加子、伊藤中
    • Total Pages
      215
    • Publisher
      クインテッセンス
    • Related Report
      2013 Annual Research Report
  • [Funded Workshop] Oral Health as the Key to Good Global Health: Challenges of Creating a Caries Free Society2016

    • Place of Presentation
      大阪市( 大阪大学中之島センター)
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-21   Modified: 2022-02-16  

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