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Development of bioactive resin containing the capacity to induce periodontal tissue formation

Research Project

Project/Area Number 25293388
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Conservative dentistry
Research InstitutionKyushu University

Principal Investigator

MAEDA HIDEFUMI  九州大学, 歯学研究科(研究院), 教授 (10284514)

Co-Investigator(Kenkyū-buntansha) 和田 尚久  九州大学, 大学病院, 教授 (60380466)
友清 淳  九州大学, 大学病院, 講師 (20507777)
赤峰 昭文  九州大学, 歯学研究科(研究院), 教授 (00117053)
門野内 聡  九州大学, 歯学研究科(研究院), 助教 (30609558)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsバイオアクティブレジン / 歯根膜組織 / 4-META/ MMA-TBBレジン / ナノハイドロキシアパタイト / 4-META/MMA-TBB レジン / 人工歯根 / 歯根膜幹細胞シート / 免疫不全ラット / 歯学 / 再生医学 / 細胞・組織 / 4-META-MMA-TBBレジン / ヒト歯根膜幹細胞株 / 硬組織形成 / ヒト歯根膜細胞 / カルシウム / 4-META/MMA-TBBレジン / 石灰化
Outline of Final Research Achievements

In this study, we aimed at developing the bioactive resin that contains the capacity to adhere the dentin and induce the formation of periodontal tissue around it in vivo. When 4-META/ MMA-TBB resin was mixed with calcium chloride or nano-sized hydroxyapatite (nHAP/SB) and then cultured with human periodontal ligament cells, it promoted bone-related gene expression. In addition, tensile test about the adhesion of this resin to bovine dentin showed the same strength level as that of the 4-META/ MMA-TBB resin mixed with nothing. When nHAP/SB was furthermore wrapped with the periodontal ligament cell sheet was embedded into rat extraction socket after 4 weeks of extraction, we found the hard tissue formation around it and moreover fibrous tissue formation around this hard tissue while Shapey’s fiber formation was not observed. These results suggested that nHAP/SB could be a candidate of the bioactive resin.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (58 results)

All 2017 2016 2015 2014 2013 2012

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Open Access: 3 results,  Acknowledgement Compliant: 7 results) Presentation (37 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results) Book (4 results)

  • [Journal Article] Glial cell line-derived neurotrophic factor from human periodontal ligament cells treated with proinflammatory cytokines promotes neurocytic differentiation of PC12 cells.2017

    • Author(s)
      Yoshida S, Yamamoto N, Wada N, Tomokiyo A, Hasegawa D, Hamano S, Mitarai H, Monnouchi S, Yuda A, Maeda H.
    • Journal Title

      J Cell Biochem.

      Volume: 118 Issue: 4 Pages: 699-708

    • DOI

      10.1002/jcb.25662

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Transforming growth factor-β-induced gene product-h3 inhibits odontoblastic differentiation of dental pulp cells.2017

    • Author(s)
      Serita S, Tomokiyo A, Hasegawa D, Hamano S, Sugii H, Yoshida S, Mizumachi H, Mitarai H, Monnouchi S, Wada N, Maeda H.
    • Journal Title

      Arch Oral Biol.

      Volume: 78 Pages: 135-143

    • DOI

      10.1016/j.archoralbio.2017.02.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Semaphorin 3A Induces Odontoblastic Phenotype in Dental Pulp Stem Cells.2016

    • Author(s)
      Yoshida S, Wada N, Hasegawa D, Miyaji H, Mitarai H, Tomokiyo A, Hamano S, Maeda H.
    • Journal Title

      Journal of Dental Research

      Volume: 95 Issue: 11 Pages: 1282-1290

    • DOI

      10.1177/0022034516653085

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Grp78 is critical for amelogenin-induced cell migration in a multipotent clonal human periodontal ligament cell line.2016

    • Author(s)
      Toyoda K, Fukuda T, Sanui T*, Tanaka U, Yamamichi K, Atomura R, Maeda H, Tomokiyo A, Taketomi T, Uchiumi T, Nishimura F
    • Journal Title

      Journal of Cellular Physiology

      Volume: 231 Issue: 2 Pages: 414-427

    • DOI

      10.1002/jcp.25087

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Benzo[a]pyrene/aryl hydrocarbon receptor signaling inhibits osteoblastic differentiation and collagen synthesis of human periodontal ligament cells.2016

    • Author(s)
      Monnouchi S, Maeda H, Yuda A, Serita S, Wada N, Tomokiyo A, Akamine A.
    • Journal Title

      J Periodontal Res.

      Volume: 51 Issue: 6 Pages: 779-788

    • DOI

      10.1111/jre.12355

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Periodontal Ligament Stem Cells in Regenerative Dentistry for Periodontal Tissues.2016

    • Author(s)
      Tomokiyo A, Wada N, Hamano S, Hasegawa D, Sugii H, Yoshida S, Maeda H.
    • Journal Title

      J Stem Cell Res Ther

      Volume: 1 Pages: 00019-00019

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Wnt5a induces collagen production by human periodontal ligament cells through TGFβ1-mediated upregulation of Periostin expression2015

    • Author(s)
      Hasegawa D, Wada N, Maeda H, Yoshida S, Mitarai H, Tomokiyo A, Monnouchi S, Hamano S, Yuda A, Akamine A
    • Journal Title

      J Cell Physiol.

      Volume: Epub ahead of print Issue: 11 Pages: 2647-2660

    • DOI

      10.1002/jcp.24950

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mechanical induction of interleukin-11 regulates osteo/cementoblastic differentiation of human periodontal ligament stem/progenitor cells.2015

    • Author(s)
      Monnouchi S, Maeda H, Yuda A, Hamano S, Wada N, Tomokiyo A, Koori K, Sugii H, Serita S, Akamine A.
    • Journal Title

      J Periodontal Res.

      Volume: 50 Issue: 2 Pages: 231-239

    • DOI

      10.1111/jre.12200

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of CTGF/CCN2 on osteo/cementoblastic and fibroblastic differentiation of a human periodontal ligament stem/progenitor cell line.2015

    • Author(s)
      Yuda A, Maeda H, Fujii S, Monnouchi S, Yamamoto N, Wada N, Koori K, Tomokiyo A, Hamano S, Hasegawa D, Akamine A
    • Journal Title

      J Cell Physiol.

      Volume: 230 Issue: 1 Pages: 150-159

    • DOI

      10.1002/jcp.24693

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regeneration of the periodontium for preservation of the damaged tooth.2014

    • Author(s)
      Maeda H, Tomokiyo A, Wada N, Koori K, Kawachi G, Akamine A.
    • Journal Title

      Histol Histopathol.

      Volume: 29 Pages: 1249-1262

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The roles of calcium-sensing receptor and calcium channel in osteogenic differentiation of undifferentiated periodontal ligament cells.2014

    • Author(s)
      Koori K, Maeda H, Fujii S, Tomokiyo A, Kawachi G, Hasegawa D, Hamano S, Sugii H, Wada N, Akamine A.
    • Journal Title

      Cell Tissue Res.

      Volume: 357 Issue: 3 Pages: 707-718

    • DOI

      10.1007/s00441-014-1918-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and effects of epidermal growth factor on human periodontal ligament cells.2014

    • Author(s)
      Teramatsu, Y, Maeda H, Sugii H, Tomokiyo A, Hamano S, Wada N, Yuda A, Yamamoto N, Koori K, Akamine A.
    • Journal Title

      Cell Tissue Res

      Volume: 357 Issue: 3 Pages: 633-643

    • DOI

      10.1007/s00441-014-1877-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Activin A on the phenotypic properties of human periodontal ligament cells.2014

    • Author(s)
      Sugii H, Maeda H, Tomokiyo A, Yamamoto N, Wada N, Koori K, Hasegawa D, Hamano S, Yuda A, Monnouchi S, Akamine A
    • Journal Title

      Bone

      Volume: 66 Pages: 62-71

    • DOI

      10.1016/j.bone.2014.05.021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective Potency of TGF-β1 on Maintenance and Regeneration of Periodontal Tissue2013

    • Author(s)
      Maeda H, Wada N, Tomokiyo A, Monnouchi S, Akamine A
    • Journal Title

      Int Rev Cell Mol Biol

      Volume: 304 Pages: 283-367

    • DOI

      10.1016/b978-0-12-407696-9.00006-3

    • ISBN
      9780124076969
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The potential role of transient receptor potential type A1 as a mechanoreceptor in human periodontal ligament cells.2013

    • Author(s)
      Tsutsumi T, Kajiya H*, Fukawa T, Sasaki M, Nemoto T, Tsuzuki T, Takahashi Y, Fujii S, Maeda H, Okabe K.
    • Journal Title

      Eur J Oral Sci

      Volume: 121 Issue: 6 Pages: 538-544

    • DOI

      10.1111/eos.12083

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective Potency of TGF-β1 on Maintenance and Regeneration of Periodontal Tissue.2013

    • Author(s)
      Maeda H, Wada N, Tomokiyo A, Monnouchi S, Akamine A
    • Journal Title

      Int Rev Cell Mol Biol.

      Volume: 304 Issue: 6 Pages: 283-367

    • DOI

      10.11607/jomi.te26

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alternation of extracellular matrix remodeling and apoptosis by activation of the aryl hydrocarbon2012

    • Author(s)
      Tomokiyo et al.
    • Journal Title

      J Cell Biochem

      Volume: 113 Issue: 10 Pages: 3093-3103

    • DOI

      10.1002/jcb.24186

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Transgelin mediates TGF-beta1-induced human periodontal ligament cell proliferation.2017

    • Author(s)
      Hiromi Mitarai, Naohisa Wada, Daigaku Hasegawa, Shinichiro Yoshida, Mai Sonoda, Atsushi Tomokiyo, Sayuri Hamano, Hidefumi Maeda.
    • Organizer
      95th General Session & Exhibition of the IADR
    • Place of Presentation
      Moscone West, San Francisco, USA
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transgelin mediates the proliferation of human periodontal ligament cells induced by TGF-β12017

    • Author(s)
      Hiromi Mitarai, Naohisa Wada, Daigaku Hasegawa, Shinichiro Yoshida, Mai Sonoda, Atsushi Tomokiyo, Sayuri Hamano, Suguru Serita, Hiroyuki Mizumachi, Hidefumi Maeda.
    • Organizer
      Kyudai Oral Bioscience 2017
    • Place of Presentation
      Kyushu University
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] R-spondin2が未分化なヒト歯根膜細胞の線維芽細胞様分化に及ぼす影響.2016

    • Author(s)
      園田麻衣、長谷川大学、和田尚久、吉田晋一郎、御手洗裕美、友清淳、濱野さゆり、前田英史
    • Organizer
      第145回日本歯科保存学会秋季学術大会
    • Place of Presentation
      キッセイ文化ホール
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 紫外線照射が歯内疾患関連細菌および歯髄細胞に及ぼす影響2016

    • Author(s)
      原口 晃、吉田晋一郎、竹下正章、角 保徳、西村英紀、前田英史、和田尚久
    • Organizer
      第145回日本歯科保存学会秋季学術大会
    • Place of Presentation
      キッセイ文化ホール
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 根管治療ならびに修復処置関連溶液によって誘導されるMineral Trioxide Aggregateの色調変化に関する比較分析2016

    • Author(s)
      友清淳、和田尚久、濱野さゆり、長谷川大学、杉井英樹、吉田晋一郎、芹田俊、御手洗裕美、水町博之、前田英史
    • Organizer
      第145回日本歯科保存学会秋季学術大会
    • Place of Presentation
      キッセイ文化ホール
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] LPS刺激歯根膜細胞におけるオートファジーの役割2016

    • Author(s)
      萩尾佳那子、大野純、山口真広、瀬野恵衣、山田和彦、米田雅裕、前田英史、廣藤卓雄
    • Organizer
      第145回日本歯科保存学会秋季学術大会
    • Place of Presentation
      キッセイ文化ホール
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯根膜および皮膚由来ヒト人工多能性幹細胞(iPSC)を用いた神経堤細胞様細胞の樹立とキャラクタリゼーション2016

    • Author(s)
      友清淳、和田尚久、濱野さゆり、長谷川大学、杉井英樹、吉田晋一郎、前田英史.
    • Organizer
      第23回日本歯科医学会総会
    • Place of Presentation
      福岡サンパレス
    • Year and Date
      2016-10-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒト歯髄細胞の老化と象牙芽細胞様分化におよぼすTNF-αの影響について2016

    • Author(s)
      野津葵、友清淳、長谷川大学、濱野さゆり、吉田晋一郎、杉井英樹、芹田俊、水町博之、御手洗裕美、和田尚久、前田英史
    • Organizer
      第37回日本歯内療法学会学術大会
    • Place of Presentation
      ウインクあいち
    • Year and Date
      2016-07-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Directing Human iPS Cells Toward PDL Stem Cells.2016

    • Author(s)
      S. Hamano, A. Tomokiyo, N. Wada, D. Hasegawa, H. Sugii, S. Yoshida, S. Serita, H. Mizumachi, H. Mitarai, H.Maeda
    • Organizer
      94th General Session & Exhibition of the IADR
    • Place of Presentation
      COEX Convention Center, Seuol, Republic of Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of a Novel Periodontal Ligament Stem Cell Marker.2016

    • Author(s)
      D. Hasegawa, N. Wada, S. Hamano, A. Tomokiyo, S. Yoshida, H. Mitarai, M. Sonoda, H. Sugii, H. Maeda
    • Organizer
      94th General Session & Exhibition of the IADR
    • Place of Presentation
      COEX Convention Center, Seuol, Republic of Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Semaphorin 3A Induces Odontoblastic Phenotype in Dental Pulp Stem Cells.2016

    • Author(s)
      S. Yoshida, N. Wada, D. Hasegawa, A. Tomokiyo, S. Hamano, H. Mitarai, H. Sugii, H. Maeda
    • Organizer
      94th General Session & Exhibition of the IADR
    • Place of Presentation
      COEX Convention Center, Seuol, Republic of Korea
    • Year and Date
      2016-06-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] iPS細胞由来の歯根膜幹細胞様細胞の樹立.2016

    • Author(s)
      濱野さゆり、友清淳、和田尚久、長谷川大学、杉井英樹、吉田晋一郎、芹田俊、水町博之、御手洗裕美、 前田英史
    • Organizer
      第144回日本歯科保存学会春季学術大会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] MESTはヒト歯根膜幹細胞における幹細胞特性の維持に関与する2016

    • Author(s)
      長谷川大学、和田尚久、濱野さゆり、友清淳、吉田晋一郎、御手洗裕美、前田英史
    • Organizer
      第144回日本歯科保存学会春季学術大会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯髄細胞におけるTGFbetaig-h3の発現および機能について2016

    • Author(s)
      芹田俊、友清淳、長谷川大学、濱野さゆり、杉井英樹、吉田晋一郎、水町博之、御手洗裕美、和田尚久、前田英史
    • Organizer
      第144回日本歯科保存学会春季学術大会
    • Place of Presentation
      栃木県総合文化センター
    • Year and Date
      2016-06-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] 歯根膜幹細胞の特性の解析2016

    • Author(s)
      前田英史
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま (郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Activin A reversely works between human pre-osteoblastic cells and periodontal ligament cells on their osteoblastic differentiation.2016

    • Author(s)
      Hideki Sugii, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Shinichiro Yoshida, Suguru Serita, Hiroyuki Mizumachi, Hiromi Mitarai, Aoi Nozu, Marina Ogawa, Mai Sonoda, Naohisa Wada, Hidefumi Maeda.
    • Organizer
      2nd symposium of Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers.
    • Place of Presentation
      Fukuoka Recent Hotel
    • Year and Date
      2016-02-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] How can we save a severely-damaged tooth?2016

    • Author(s)
      Hidefumi Maeda.
    • Organizer
      Kyudai Oral Bioscience 2016
    • Place of Presentation
      Kyushu University
    • Year and Date
      2016-02-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト歯髄細胞の石灰化におけるCalcium-sensing receptorの関与について2015

    • Author(s)
      水町博之、友清淳、長谷川大学、濱野さゆり、吉田晋一郎、杉井英樹、芹田俊、御手洗裕美、和田尚久、前田英史
    • Organizer
      第143回日本歯科保存学会秋季学術大会
    • Place of Presentation
      文京区シビックホール(東京都)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 炎症性サイトカインで刺激したヒト歯根膜細胞由来のGDNFはPC12の神経細胞分化を促進する2015

    • Author(s)
      吉田晋一郎、山本直秀、和田尚久、友清淳、長谷川大学、濱野さゆり、祐田明香、御手洗裕美、杉井英樹、前田英史.
    • Organizer
      第143回日本歯科保存学会秋季学術大会
    • Place of Presentation
      文京区シビックホール(東京都)
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯根膜および皮膚由来ヒト人工多能性幹細胞(iPSC)を用いた神経堤細胞様細胞の樹立とその表現型の比較.2015

    • Author(s)
      友清淳、前田英史、和田尚久、門野内聡、濱野さゆり、長谷川大学、祐田明香、赤峰昭文
    • Organizer
      第142回日本歯科保存学会春季学術大会
    • Place of Presentation
      西日本総合展示場 (北九州市)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 歯根膜細胞におけるα-SMA発現にTransgelinが関与する2015

    • Author(s)
      御手洗裕美、和田尚久、前田英史、長谷川大学、吉田晋一郎、濱野さゆり、祐田明香、友清淳、赤峰昭文
    • Organizer
      第142回日本歯科保存学会春季学術大会
    • Place of Presentation
      西日本総合展示場 (北九州市)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Collaborative Activity of CTGF/CCN2 and TGF-β1 on Osteogenesis and Fibrogenesis.2015

    • Author(s)
      A. Yuda, H. Maeda, S. Fujii, S. Monnouchi, N. Wada, A. Tomokiyo, S. Hamano, D. Hasegawa, H. Sugii, S. Yoshida, A. Akamine.
    • Organizer
      93rd General Session & Exhibition of the IADR
    • Place of Presentation
      Boston
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of β2 Adrenergic Receptor on Human Periodontal Ligament Cells.2015

    • Author(s)
      S. Hamano, H. Maeda, D. Hasegawa, S. Monnouchi, N. Wada, A. Tomokiyo, A. Yuda, H. Sugii, S. Yoshida, A. Akamine.
    • Organizer
      93rd General Session & Exhibition of the IADR
    • Place of Presentation
      Boston
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] The Effects of Wnt5a on Human Periodontal Ligament Cells.2015

    • Author(s)
      100)D. Hasegawa, N. Wada, H. Maeda, S. Yoshida, H. Mitarai, A. Tomokiyo, S. Monnouchi, S. Hamano, A. Yuda, A. Akamine.
    • Organizer
      93rd General Session & Exhibition of the IADR
    • Place of Presentation
      Boston
    • Year and Date
      2015-03-11 – 2015-03-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨芽細胞様分化におけるActivin Aの作用は前骨芽細胞と歯根膜細胞とで相反する2014

    • Author(s)
      杉井英樹、前田英史、友清淳、和田尚久、門野内聡、長谷川大学、濱野さゆり、祐田明香、吉田晋一郎、赤峰昭文:
    • Organizer
      第141回日本歯科保存学会秋季学術大会
    • Place of Presentation
      山形テルサ
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Wnt5aはRor2-JNKシグナルを介してヒト歯根膜幹細胞株の骨芽細胞様分化を抑制する2014

    • Author(s)
      長谷川大学、和田尚久、前田英史、吉田晋一郎、御手洗裕美、門野内聡、濱野さゆり、祐田明香、赤峰昭文
    • Organizer
      第141回日本歯科保存学会秋季学術大会
    • Place of Presentation
      山形テルサ
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 2アドレナリン受容体の作動薬および非作動薬がヒト歯根膜細胞に及ぼす影響.2014

    • Author(s)
      濱野さゆり、前田英史、長谷川大学、和田尚久、友清淳、門野内聡、祐田明香、杉井英樹、赤峰昭文
    • Organizer
      第140回日本歯科保存学会春季学術大会
    • Place of Presentation
      滋賀県立芸術劇場びわ湖ホール
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Wnt5aはTGFbeta1を介してヒト歯根膜細胞のコラーゲン線維形成を促進する2014

    • Author(s)
      長谷川大学、和田尚久、前田英史、吉田晋一郎、門野内聡、御手洗裕美、濱野さゆり、祐田明香、赤峰昭文
    • Organizer
      第140回日本歯科保存学会春季学術大会
    • Place of Presentation
      滋賀県立芸術劇場びわ湖ホール
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Semaphorin3Aがヒト歯髄幹細胞による硬組織形成に及ぼす影響2014

    • Author(s)
      吉田晋一郎、和田尚久、前田英史、門野内聡、長谷川大学、御手洗裕美、濱野さゆり、祐田明香、杉井英樹、赤峰昭文
    • Organizer
      第140回日本歯科保存学会春季学術大会
    • Place of Presentation
      滋賀県立芸術劇場びわ湖ホール
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation of calcium-modified 4-META/MMA-TBB resin on its bioactive feature.2013

    • Author(s)
      MAEDA H, KOORI K, WADA N, MONNOUCHI S, TERAMATSU Y, KONO K, and AKAMINE A.
    • Organizer
      The 9th World Endodontic Congress of IFEA.
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] Localization of βig-h3 and Collagen Type I in Dental Pulp.2013

    • Author(s)
      MONNOUCHI S, MAEDA H, YUDA A, and AKAMINE A.
    • Organizer
      The 9th World Endodontic Congress of IFEA.
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] Dental Pulp Stem Cells on Bone Tissue Express Periodontal Ligament-related gene.2013

    • Author(s)
      YOSHIDA S, WADA N, MAEDA H, HASEGAWA D, SATO H, MONNOUCHI S, and AKAMINE A.
    • Organizer
      The 9th World Endodontic Congress of IFEA.
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular Assessment of Bacterial Community in Persistent Apical Periodontitis Granulomatous Tissue: 16S rDNA Clone Library Analysis.2013

    • Author(s)
      ZAKARIA MN, MAEDA H, WADA N, and AKAMINE A.
    • Organizer
      The 9th World Endodontic Congress of IFEA.
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] Activin Aがヒト歯根膜細胞に及ぼす影響について2013

    • Author(s)
      杉井英樹、前田英史、友清淳、山本直秀、郡勝明、和田尚久、門野内聡、濱野さゆり、長谷川大学、祐田明香、寺松陽子、河野清美、吉田晋一郎、赤峰昭文
    • Organizer
      第138回日本歯科保存学会春季学術大会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] CTGF/CCN2が未分化なヒト歯根膜細胞株の骨芽細胞様分化に及ぼす影響2013

    • Author(s)
      祐田明香、前田英史、藤井慎介、門野内聡、山本直秀、和田尚久、友清淳、郡勝明、濱野さゆり、赤峰昭文
    • Organizer
      第5回日本CCNファミリー研究会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2013 Annual Research Report
  • [Presentation] Wnt5aがヒト歯根膜細胞に及ぼす影響について2013

    • Author(s)
      長谷川大学、和田尚久、前田英史、友清淳、門野内聡、郡勝明、吉田晋一郎、寺松陽子、濱野さゆり、祐田明香、杉井英樹、赤峰昭文
    • Organizer
      第139回日本歯科保存学会秋季学術大会
    • Place of Presentation
      秋田総合生活文化会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 水酸化カルシウム貼薬が根管封鎖性に及ぼす影響の解析2013

    • Author(s)
      野村育子、後藤康治、前田英史、赤峰昭文
    • Organizer
      第139回日本歯科保存学会秋季学術大会
    • Place of Presentation
      秋田総合生活文化会館
    • Related Report
      2013 Annual Research Report
  • [Book] Frontiers in Stem Cell and Regenerative Medicine Research2016

    • Author(s)
      Tomokiyo A, Wada N, Maeda H.
    • Total Pages
      294
    • Publisher
      Bentham Science
    • Related Report
      2016 Annual Research Report
  • [Book] Springer2016

    • Author(s)
      Wada N, Tomokiyo A, Maeda H
    • Total Pages
      309
    • Publisher
      Dental Stem Cells.
    • Related Report
      2016 Annual Research Report
  • [Book] Frontiers in Stem Cell and Regenerative Mudicine Research2016

    • Author(s)
      Tomokiyo A, Wada N, Maeda H
    • Publisher
      Bentham Science
    • Related Report
      2015 Annual Research Report
  • [Book] Year Book 2014 「今だから押さえておきたい! 世界の歯内療法の潮流」2014

    • Author(s)
      前田英史
    • Total Pages
      169
    • Publisher
      クインテッセンス出版
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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