| Co-Investigator(Kenkyū-buntansha) |
和田 尚久 九州大学, 大学病院, 教授 (60380466)
友清 淳 九州大学, 大学病院, 講師 (20507777)
赤峰 昭文 九州大学, 歯学研究科(研究院), 教授 (00117053)
門野内 聡 九州大学, 歯学研究科(研究院), 助教 (30609558)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
In this study, we aimed at developing the bioactive resin that contains the capacity to adhere the dentin and induce the formation of periodontal tissue around it in vivo. When 4-META/ MMA-TBB resin was mixed with calcium chloride or nano-sized hydroxyapatite (nHAP/SB) and then cultured with human periodontal ligament cells, it promoted bone-related gene expression. In addition, tensile test about the adhesion of this resin to bovine dentin showed the same strength level as that of the 4-META/ MMA-TBB resin mixed with nothing. When nHAP/SB was furthermore wrapped with the periodontal ligament cell sheet was embedded into rat extraction socket after 4 weeks of extraction, we found the hard tissue formation around it and moreover fibrous tissue formation around this hard tissue while Shapey’s fiber formation was not observed. These results suggested that nHAP/SB could be a candidate of the bioactive resin.
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