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Establishment of iPS cell-based bone tissue engineering using small molecule compounds

Research Project

Project/Area Number 25293395
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionTohoku University

Principal Investigator

Egusa Hiroshi  東北大学, 歯学研究科(研究院), 教授 (30379078)

Co-Investigator(Kenkyū-buntansha) YATANI Hirofumi  大阪大学, 大学院歯学研究科, 教授 (80174530)
Co-Investigator(Renkei-kenkyūsha) MATSUMOTO Takuya  岡山大学, 大学院医歯薬学総合研究科, 教授 (40324793)
SAEKI Makio  新潟大学, 大学院医歯学総合研究科, 教授 (30273692)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords再生歯学 / 骨再生 / iPS細胞 / 小分子化合物
Outline of Final Research Achievements

Bone regeneration and augmentation in dental treatments cannot be easily accomplished because conventional bone grafting materials are not osteoinductive. Induced pluripotent stem cells (iPS cells) are expected to be useful for alveolar bone augmentation/regeneration; however, their clinical application will require complete differentiation toward an osteogenic cell fate to avoid tumor formation. In this research project, we found several small molecule compounds, which enhance osteogenic differentiation of iPS cells, and that application of statins to iPS cell constructs enables efficient bone augmentation and suppresses tumor formation in an animal model. These findings represent an important step toward the therapeutic application of iPS cells to bone tissue engineering in dentistry.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (47 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (32 results) (of which Int'l Joint Research: 6 results,  Invited: 30 results) Book (3 results)

  • [Int'l Joint Research] チュラロンコン大学(タイ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Scaffold-free fabrication of osteoinductive cellular constructs using mouse gingiva-derived induced pluripotent stem cells.2016

    • Author(s)
      Okawa H, Kayashima H, Sasaki JI, Miura J, Kamano Y, Imazato S, Yatani H, Matsumoto T, Egusa H.
    • Journal Title

      Stem Cells International

      Volume: 2016 Issue: 1 Pages: 1-11

    • DOI

      10.1155/2016/6240794

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia enhances osteogenic differentiation in retinoic acid-treated murine induced pluripotent stem cells2016

    • Author(s)
      Manokawinchoke J, Osathanon T, Egusa H, Pavasant P
    • Journal Title

      Tissue Eng Regen Med

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biodental engineering.2015

    • Author(s)
      Matsumoto T, Egusa H, Kato K, Tsuji T
    • Journal Title

      Journal of Oral Biosciences

      Volume: 57(2) Issue: 2 Pages: 80-85

    • DOI

      10.1016/j.job.2015.01.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative Analysis of Mouse Induced Pluripotent Stem Cells and Mesenchymal Stem Cells during Osteogenic Differentiation in vitro.2014

    • Author(s)
      Egusa, H., Kayashima, H., Miura, J., Uraguchi, S., Wang, F., Okawa, H., Sasaki, J.I., Saeki, M., Matsumoto, T., and Yatani, H.
    • Journal Title

      Stem cells and development.

      Volume: 23 Issue: 18 Pages: 2156-2169

    • DOI

      10.1089/scd.2013.0344

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Expression of neuropeptide receptor mRNA during osteoblastic differentiation of mouse iPS cells.2014

    • Author(s)
      Nagao, S. Goto, T. Kataoka, S. Toyono, T. Joujima, T. Egusa, H. Yatani, H. Kobayashi, S. Maki, K.
    • Journal Title

      Neuropeptides

      Volume: 48 Issue: 6 Pages: 399-406

    • DOI

      10.1016/j.npep.2014.10.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increasing diversity in prosthodontic research2014

    • Author(s)
      Egusa H
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 58 Issue: 4 Pages: 191-192

    • DOI

      10.1016/j.jpor.2014.08.002

    • NAID

      130004714114

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 歯肉を用いた医療応用に安全なiPS 細胞の開発―新たな再生歯科医療技術の創成に向けて―2014

    • Author(s)
      江草 宏,于 冠男,鎌野優弥,大川博子,山本治毅,矢谷博文
    • Journal Title

      日歯医学会誌

      Volume: 33 Pages: 54-58

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Novel strategies for the development of anabolic agents for treatment of osteoporosis2014

    • Author(s)
      佐伯万騎男,江草 宏
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 144 Issue: 6 Pages: 277-280

    • DOI

      10.1254/fpj.144.277

    • NAID

      130004704245

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 歯肉を用いた医療応用に安全なiPS 細胞の開発 ―新たな再生歯科医療技術の創成に向けて―2014

    • Author(s)
      江草 宏,于 冠男,鎌野優弥,大川博子,山本治毅,矢谷博文
    • Journal Title

      日歯医学会誌

      Volume: 33 Pages: 54-58

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frontier dental research on iPS cells2013

    • Author(s)
      Arakaki M, Egusa H, Otsu K, Saitoh I, Miura T, Harada H
    • Journal Title

      Journal of Oral Biosciences

      Volume: 55:4 Issue: 4 Pages: 159-164

    • DOI

      10.1016/j.job.2013.08.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] iPS細胞の骨生物学への応用と歯科臨床への展望2013

    • Author(s)
      江草 宏
    • Journal Title

      医学生物学電子顕微鏡技術学会誌

      Volume: 27 Pages: 67-69

    • Related Report
      2013 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] iPS細胞を用いた骨再生医療戦略2016

    • Author(s)
      江草 宏
    • Organizer
      第70回 東京工業大学精密工学研究所シンポジウム
    • Place of Presentation
      横浜市
    • Year and Date
      2016-03-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] iPS Cell-Based Strategies in Bone Tissue Engineering2016

    • Author(s)
      江草 宏
    • Organizer
      The 6th International Symposium for Interface Oral Health Science
    • Place of Presentation
      仙台市
    • Year and Date
      2016-01-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS cells: What they are and what they can contribute to the field of dentistry2015

    • Author(s)
      江草 宏
    • Organizer
      Chulalongkorn-Tohoku Joint Symposium in Dental Science 2015
    • Place of Presentation
      Bangkok, Thai
    • Year and Date
      2015-12-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] iPS cells and their expected role in the future of dentistry2015

    • Author(s)
      江草 宏
    • Organizer
      The 3rd Sino-Japan Dental Science Symposium
    • Place of Presentation
      Fujian, China
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞技術が描く歯科医療の未来2015

    • Author(s)
      江草 宏
    • Organizer
      平成27年度 日本補綴歯科学会東北・北海道支部学術大会
    • Place of Presentation
      盛岡市
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] iPS cells: What they are and what they can contribute to the field of dentistry2015

    • Author(s)
      江草 宏
    • Organizer
      Hongkong Univesity-Tohoku University 1st Bilateral Dental Symposium
    • Place of Presentation
      香港
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS細胞を用いた骨再生研究とインプラント臨床への展望2015

    • Author(s)
      江草 宏
    • Organizer
      第45回 日本口腔インプラント学会学術大会
    • Place of Presentation
      岡山市
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] iPS cells and their expected role in the future of prosthodontics2015

    • Author(s)
      江草 宏
    • Organizer
      16th Biennial Meeting of International College of Prosthodontists
    • Place of Presentation
      Seoul, 韓国
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] iPS cells and their expected role in the future of prosthodontics2015

    • Author(s)
      江草 宏
    • Organizer
      16th Biennial Meeting of International College of Prosthodontists
    • Place of Presentation
      Seoul(韓国)
    • Year and Date
      2015-09-17 – 2015-09-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] iPS細胞が可能にする歯科医療とは2015

    • Author(s)
      江草 宏
    • Organizer
      日本臨床歯周病学会第33回年次大会
    • Place of Presentation
      仙台市
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Invited
  • [Presentation] iPS cells: What they are and what they can contribute to the field of dentistry2015

    • Author(s)
      江草 宏
    • Organizer
      Sichuan-Tohoku Dental Symposium 2015
    • Place of Presentation
      Sichuan, China
    • Year and Date
      2015-07-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 歯科領域における再生医療の動向と展望2015

    • Author(s)
      江草 宏
    • Organizer
      日本組織培養学会第88回大会
    • Place of Presentation
      広島市
    • Year and Date
      2015-05-27
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Invited
  • [Presentation] 歯科領域における再生医療の動向と展望2015

    • Author(s)
      江草 宏
    • Organizer
      第69回 日本口腔科学会学術集会
    • Place of Presentation
      大阪府
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 歯科領域における再生医療の動向と展望2015

    • Author(s)
      江草 宏
    • Organizer
      第69回 日本口腔科学会学術集会 教育研修会
    • Place of Presentation
      大阪府
    • Year and Date
      2015-05-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] iPS cells: What they are and what they can contribute to prosthodontics2015

    • Author(s)
      江草 宏
    • Organizer
      2015 Biennial Joint Congress of JPS-CPS-KAP
    • Place of Presentation
      箱根
    • Year and Date
      2015-04-11
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Application of iPS Cells in bone biology2014

    • Author(s)
      江草 宏
    • Organizer
      China-Japan-Korea Dental Science Symposium 2014
    • Place of Presentation
      Dalian(中国)
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] iPS細胞が可能にする歯科医療とは2014

    • Author(s)
      江草 宏
    • Organizer
      第73回 日本矯正歯科学会学術大会
    • Place of Presentation
      千葉市
    • Year and Date
      2014-10-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] iPS細胞の骨生物学への応用と歯科臨床への展望2014

    • Author(s)
      江草 宏
    • Organizer
      平成26年度 日本歯科理工学会 北海道・東北地方会夏季セミナー
    • Place of Presentation
      仙台市
    • Year and Date
      2014-08-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] iPS細胞が可能にする歯科医療とは2014

    • Author(s)
      江草 宏
    • Organizer
      第65回 東北大学歯学会
    • Place of Presentation
      仙台市
    • Year and Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] iPS細胞が可能にする歯科医療とは2014

    • Author(s)
      江草 宏
    • Organizer
      昭和大学 学士会後援セミナー
    • Place of Presentation
      東京都
    • Year and Date
      2014-05-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] iPS細胞の骨形成能と歯科臨床への展望2014

    • Author(s)
      江草 宏
    • Organizer
      第68回 日本口腔科学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2014-05-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] iPS細胞が可能にする歯科医療とは2014

    • Author(s)
      江草 宏
    • Organizer
      第47回 新潟歯学会総会
    • Place of Presentation
      新潟市
    • Year and Date
      2014-04-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Application of iPS Cells in bone biology2014

    • Author(s)
      江草 宏
    • Organizer
      Kyudai Oral Bioscience 2014
    • Place of Presentation
      福岡市
    • Year and Date
      2014-02-28
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] iPS Cells in Regenerative Dental Medicine2014

    • Author(s)
      江草 宏
    • Organizer
      The 5th International Symposium for Interface Oral Health Science
    • Place of Presentation
      仙台市
    • Year and Date
      2014-01-21
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Stem cells in regenerative dental medicine2013

    • Author(s)
      江草 宏
    • Organizer
      The 5th International Symposium for Interface Oral Health Science
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2013-11-28
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 歯肉から作るiPS細胞が可能にする歯科医療とは2013

    • Author(s)
      江草 宏
    • Organizer
      日本補綴歯科学会関西支部学術大会
    • Place of Presentation
      大阪市
    • Year and Date
      2013-11-24
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 歯肉から作るiPS細胞が可能にする歯科医療とは2013

    • Author(s)
      江草 宏
    • Organizer
      第25回 日本小児口腔外科学会学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2013-11-02
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いたスキャフォールドフリー骨組織再生2013

    • Author(s)
      江草 宏
    • Organizer
      第55回 歯科基礎医学会学術大会
    • Place of Presentation
      岡山市
    • Year and Date
      2013-09-22
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Simvastatinがマウス歯肉線維芽細胞由来iPS細胞の骨芽細胞分化に及ぼす影響2013

    • Author(s)
      大川博子,江草 宏,矢谷博文
    • Organizer
      第55回 歯科基礎医学会学術大会
    • Place of Presentation
      岡山市
    • Year and Date
      2013-09-22
    • Related Report
      2013 Annual Research Report
  • [Presentation] 移植に安全なiPS細胞技術を基盤とした新規骨増生術の開発2013

    • Author(s)
      萱島浩輝,江草 宏,飯田 務,明石喜裕,矢谷博文
    • Organizer
      第43回日本口腔インプラント学会学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-09-15
    • Related Report
      2013 Annual Research Report
  • [Presentation] iPS細胞の骨生物学への応用と歯科臨床への展望2013

    • Author(s)
      江草 宏
    • Organizer
      第29回 医学生物学電子顕微鏡技術学会
    • Place of Presentation
      横須賀市
    • Year and Date
      2013-06-09
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] iPS細胞の骨形成能と歯科臨床への展望2013

    • Author(s)
      江草 宏
    • Organizer
      第67回 日本口腔科学会学術集会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2013-05-23
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Interface Oral health Science 2014(Chapter 12: Feeder cell sources and feeder-free methods for human iPS cell culture)2015

    • Author(s)
      Yu G, Kamano Y, Wang F, Okawa H, Yatani H, Egusa H
    • Total Pages
      351
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] 口腔組織学・発生学 第2版(第3章V-3:幹細胞と再生歯科医療)2015

    • Author(s)
      天野 修、飯村忠浩、泉 健次、井上 孝、入江一元、江草 宏、興地隆史、大峡 淳、城戸瑞穂、笹野泰之、髙野吉郎、中沢勝宏、中村雅典、原田英光、福本 敏、村上伸也、山座孝義、山城 隆、吉山昌宏、脇坂聡、他
    • Total Pages
      384
    • Publisher
      医歯薬出版
    • Related Report
      2014 Annual Research Report
  • [Book] 冠橋義歯補綴学テキスト(Sec. 6-2:再生医療の固定性補綴治療への展開)2015

    • Author(s)
      會田雅啓、魚島勝美、江草 宏、越智守生、木本克彦、佐藤 亨、 佐藤博信、澤瀬 隆、新谷明喜、田中昌博、馬場一美、藤澤政紀、松香芳三、松村英雄、南 弘之、山口泰彦
    • Total Pages
      280
    • Publisher
      末永書店
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2017-05-10  

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