| Project/Area Number |
25293397
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Matsumoto Dental University (2015)
Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOSOKAWA RYUJI 九州歯科大学, 歯学部, 教授 (60211546)
MASAKI CHIHIRO 九州歯科大学, 歯学部, 准教授 (60397940)
KONDO YUSUKE 九州歯科大学, 歯学部, 助教 (00611287)
MUKAIBO TARO 九州歯科大学, 歯学部, 助教 (50635117)
KUROIWA AKIHIRO 松本歯科大学, 歯学部, 教授 (10195571)
KURASAWA IKUFUMI 松本歯科大学, 歯学部, 教授 (60131059)
TSUCHIYA SOUICHIRO 松本歯科大学, 歯学部, 講師 (70236909)
KOMACHIYA MIHO 松本歯科大学, 歯学部, 助教 (00387432)
MATSUYAMA YUKI 松本歯科大学, 歯学部, 助教 (30532783)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | 唾液腺 / 口腔乾燥症 / イオン輸送担体 / 低浸透圧 / タンニン酸 / メカノバイオロジー / 口腔乾燥 / 上皮膜輸送 / イオンチャネル / 水分泌 / 糖尿病 / 陰イオンチャネル / トランスポーター |
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| Outline of Final Research Achievements |
We analyzed fluid secretion from salivary gland under hypotonic condition to investigate mechanobiology. Saliva secretion was increased under hypotonic condition due to functional upregulation of ion transporter located in basolateral membrane of acinar cells. On the other hand, anion channel in apical membrane was inhibited by tannic acid and substances containing it. As a result, fluid secretion was decreased. For the recovery of the function of fluid secretion, the activation of ion transporters might become a new tool.
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