Pathogenesis of inflammation or allergy in dental metal material
| Project/Area Number |
25293399
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA MASAFUMI 東北大学, 加齢医学研究所, 助教 (20453582)
川野 光子 東北大学, 加齢医学研究所, 助教 (90422203)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | アレルギー / アレルギー・ぜんそく / 炎症 / 金属 / NK細胞 |
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| Outline of Final Research Achievements |
Metal is used as a component of biomaterials in dental care, because metal has stiffness, elasticity, and ductility. In dental care, the metal is frequently used as a part of denture, an implant and restoration. However, the molecular mechanisms underlying metal inflammation and metal allergy have not been understood. In this study, we examined the molecular mechanism of development for metal allergy and inflammation by focusing NK cells and NK receptors. We found that NKG2D, a NK activating receptor, is expressed on CD8+T cells are involved in metal allergy.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] NKG2D functions as an activating receptor on natural killer cells in common marmoset (callithrix jacchus).2014
Author(s)
Watanabe M, Kudo Y, Kawano M, Nakayama M, Nakamura K, Kameda M, Ebara M, Sato T, Nakamura M, Omine K, Kametani Y, Suzuki R, Ogasawara K.
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Journal Title
Int Immunol.
Volume: 26
Issue: 11
Pages: 597-606
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of T cell receptors of Th1 cells infiltrating inflamed skin of a novel murine model of palladium-induced metal allergy.2013
Author(s)
Kobayashi H, Kumagai K, Eguchi T, Shigematsu H, Kitaura K, Kawano M, Horikawa T, Suzuki S, Matsutani T, Ogasawara K, Hamada Y, Suzuki R.
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Journal Title
PLoS One
Volume: 8
Issue: 10
Pages: e76385-e76385
DOI
Related Report
Peer Reviewed
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[Presentation] がんとNK細胞2014
Author(s)
小笠原康悦
Organizer
第56回 歯科基礎医学会
Place of Presentation
福岡
Year and Date
2014-09-25 – 2014-09-27
Related Report
Invited
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