| Project/Area Number |
25293399
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA MASAFUMI 東北大学, 加齢医学研究所, 助教 (20453582)
川野 光子 東北大学, 加齢医学研究所, 助教 (90422203)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | アレルギー / アレルギー・ぜんそく / 炎症 / 金属 / NK細胞 |
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| Outline of Final Research Achievements |
Metal is used as a component of biomaterials in dental care, because metal has stiffness, elasticity, and ductility. In dental care, the metal is frequently used as a part of denture, an implant and restoration. However, the molecular mechanisms underlying metal inflammation and metal allergy have not been understood. In this study, we examined the molecular mechanism of development for metal allergy and inflammation by focusing NK cells and NK receptors. We found that NKG2D, a NK activating receptor, is expressed on CD8+T cells are involved in metal allergy.
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