Patient-derived dental pulp stem cell-based innovation for disease mechanism and therapeutic development in cleft lip palate
| Project/Area Number |
25293405
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZA Haruyoshi 九州大学, 大学院歯学研究院, 講師 (30336151)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Keywords | 歯髄幹細胞 / 口唇口蓋裂 / 患者由来幹細胞 / 乳歯幹細胞 / 疾患由来幹細胞 / 細胞内シグナル分子 / エピゲニック制御 / 再生医療 |
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| Outline of Final Research Achievements |
In this project, we evaluated that CL/P patient-derived SHED expressed an enhanced phosphorylation of ERK1/2 to suppress their regenerative capacity to form bone tissue. The enhancement of ERK1/2 in CL/P patient-derived SHED was caused by hypomethylation of DUSP4 and 6 DNA promoters. The inhibited bone regenerative capacity in CL/P patient-derived SHED was rescued by inhibition of ERK1/2 phosphorylation. These findings suggested that, in future, a promising therapeutics with autologous SHED-based bone regeneration will be developed in CL/P treatment.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells.2016
Author(s)
Sonoda S, Yamaza H, Ma L, Tanaka Y, Tomoda E, Aijima R, Nonaka K, Kukita T, Shi S, Nishimura F, Yamaza T.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 19286-19286
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice.2015
Author(s)
Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T.
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Journal Title
Stem Cell Res Ther
Volume: 6(1)
Issue: 1
Pages: 171-171
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice.2015
Author(s)
Ma L, Aijima R, Hoshino Y, Yamaza H, Tomoda E, Tanaka Y, Sonoda S, Song G, Zhao W, Nonaka K, Shi S, Yamaza T
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Journal Title
Stem Cell Res. Ther.
Volume: 6(1)
Issue: 1
Pages: 182-182
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Ossifying Fibroma Tumor Stem Cells Are Maintained by Epigenetic Regulation of a TSP1⁄TGF-β⁄SMAD3 Autocrine Loop.2013
Author(s)
Qin H, Qu C, Yamaza T,Yang R, Lin X, Duan XY, Akiyama K, Liu Y, Zhang Q, Chen C, Chen Y, Qi HH, Feng XH, Le AD, Shi S.
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Journal Title
Cell Stem Cell.
Volume: 13
Issue: 5
Pages: 577-589
DOI
Related Report
Peer Reviewed
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