New therapeutic strategy for oral cancer based on gene response to hypoxia by molecular imaging

• Project/Area Number: 25293406
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: KITAGAWA Yoshimasa 北海道大学, 歯学研究科(研究院), 教授 (00224957)
• Co-Investigator(Kenkyū-buntansha): YAMAZAKI Yutaka 北海道大学, 大学院歯学研究科, 教授 (90250464) ; TAMAKI Nagara 北海道大学, 大学院医学研究科, 教授 (30171888) ; INUBUSHI Masayuki 川崎医科大学, 医学部, 准教授 (70399830)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
• Keywords: 分子イメージング / 遺伝子イメージング / 低酸素 / PET / 頭頸部癌 / 化学療法 / 放射線治療 / 治療抵抗性 / 核医学（PET) / FMISO / 口腔がん / 臨床研究 / 動物モデル / 核医学(PET) / 口腔癌

Outline of Final Research Achievements

The correlations of FMISO-PET and FDG-PET with histological response to preoperative chemotherapy were assessed in patients with OSCC. This study enrolled 22 patients with OSCC undergoing preoperative chemotherapy. Each patient was evaluated by both FMISO-PET and FDG-PET before surgery, Good response was significantly more prevalent in patients with negative than positive FMISO uptake and without the hypoxic area evaluated by FMISO-PET TMR . An advantage of FMISO-PET over FDG-PET for predicting histological response to preoperative chemotherapy in patients with OSCC was observed.
The tumor uptake level of hypoxia-targeted PET tracers reflected the gene activation level by HRE, which eventually conferred the resistance to anti-cancer therapies on the tumor cells and tracer distribution of 18F-FMISO PET might be more suitable than that of 64Cu-ATSM PET for planning hypoxia-targeted radiotherapy.

Research Products

• [Journal Article] Use of FDG-PET to detect a chronic odontogenic infection as a possible source of the brain abscess. (2016)
  • Author(s): 2)Sato J, Kuroshima T, Wada M, Satoh A, Watanabe S, Okamoto S, Shiga T, Tamaki N, Kitagawa Y
  • Journal Title: Odontology Volume: 104 Issue: 2 Pages: 239-243
  • DOI: 10.1007/s10266-015-0218-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evaluation of the level of progression of extracapsular spread for cervical lymph node metastasis in oral squamous cell carcinoma. (2016)
  • Author(s): Yamada S, Yanamoto S, Otani S, Hasegawa T, Miyakoshi M, Minamikawa T, Ohga N, Kamata T, Komori T, Kitagawa Y, Kurita H, Umeda M.
  • Journal Title: Int J Oral Maxillofac Surg Volume: 45(2) Issue: 2 Pages: 141-6
  • DOI: 10.1016/j.ijom.2015.09.005
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of PET/CT with (18)F-fluoroazomycin arabinoside for patients with head and neck squamous cell carcinomas receiving chemoradiotherapy. (2016)
  • Author(s): Saga T, Inubushi M, Koizumi M, Yoshikawa K, Zhang MR, Obata T, Tanimoto K, Harada R, Uno T, Fujibayashi Y.
  • Journal Title: Ann Nucl Med. Volume: 30 Issue: 3 Pages: 217-224
  • DOI: 10.1007/s12149-015-1048-5
  • Peer Reviewed
• [Journal Article] Prognostic value of 18 F-fluoroazomycin arabinoside PET/CT in patients with advanced non-small cell lung cancer. Cancer Sci. (2015)
  • Author(s): Saga T, Inubushi M, Koizumi M, Yoshikawa K, Zhang MR, Tanimoto K, Horiike A, Yanagitani N, Ohyanagi F, Nishio M.
  • Journal Title: Cancer Sci. Volume: 106 Issue: 11 Pages: 1554-1560
  • DOI: 10.1111/cas.12771
  • Peer Reviewed / Open Access
• [Journal Article] Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET. (2015)
  • Author(s): Miwa K, Inubushi M, Takeuchi Y, Katafuchi T, Koizumi M, Saga T, Sasaki M.
  • Journal Title: Annals of Nuclear Medicine Volume: 29 Issue: 5 Pages: 460-466
  • DOI: 10.1007/s12149-015-0966-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] FDG-PET may predict the effectiveness of hyperbaric oxygen therapy in a patient with bisphosphonate-related osteonecrosis of the jaw: report of a case. (2015)
  • Author(s): Fatema CN, Sato J, Yamazaki Y, Hata H, Hattori N, Shiga T, Tamaki N, Kitagawa Y.
  • Journal Title: Odontology Volume: 103 Issue: 1 Pages: 105-108
  • DOI: 10.1007/s10266-013-0129-y
  • Peer Reviewed
• [Journal Article] Changes in tumor oxygen state after sorafenib therapy evaluated by 18F- fluoromisonidazole hypoxia imaging of renal cell carcinoma xenograft, (2015)
  • Author(s): 于 聞文 、趙 松吉、趙 芫、チョウドリ ヌスラット ファティマ、 村上 正紘、西嶋 剣一、北川 善政、玉木 長良、久下 裕司
  • Journal Title: 北海道歯学雑誌 Volume: 2
  • Peer Reviewed
• [Journal Article] Detailed assessment of gene activation levels by multiple hypoxia-responsive elements under various hypoxic conditions. (2014)
  • Author(s): Takeuchi Y, Inubushi M, Jin YN, Murai C, Tsuji AB, Hata H, Kitagawa Y, Saga T
  • Journal Title: Ann Nucl Med Volume: 28 Issue: 10 Pages: 1011-1019
  • DOI: 10.1007/s12149-014-0901-2
  • Peer Reviewed / Open Access
• [Journal Article] Advantage of FMISO-PET over FDG-PET for predicting histological response to preoperative chemotherapy in patients with oral squamous cell carcinoma. (2014)
  • Author(s): Sato J, Kitagawa Y, Yamazaki Y, Hata H, Asaka T, Miyakoshi M, Okamoto S, Shiga T, Shindoh M, Kuge Y, Tamaki N
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 41(11) Issue: 11 Pages: 2031-2041
  • DOI: 10.1007/s00259-014-2810-y
  • Peer Reviewed
• [Journal Article] Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer xenografts using radiolabeled FMISO and FLT. (2014)
  • Author(s): Fatema CN, Zhao S, Zhao Y, Yu W, Nishijima K, Yasuda K, Kitagawa Y, Tamaki N, Kuge Y.
  • Journal Title: BMC Cancer Volume: 14 Issue: 1 Pages: 692-692
  • DOI: 10.1186/1471-2407-14-692
  • NAID: 120005496510
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 18F-Fluoromisonidazole PET Uptake Is Correlated with Hypoxia-Inducible Factor-1α Expression in Oral Squamous Cell Carcinoma. (2013)
  • Author(s): Sato J, Kitagawa Y, Yamazaki Y, Tamaki N, et al
  • Journal Title: J Nuclear Medicine Volume: 54 Issue: 7 Pages: 1060-1065
  • DOI: 10.2967/jnumed.112.114355
  • Peer Reviewed
• [Journal Article] Monitoring intratumoral proliferative responses to radiotherapy by 18F-fluorothymidine in a human head and neck cancer xenograft: comparison with Ki-67. (2013)
  • Author(s): Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima K, Tamaki N, Kitagawa Y, Kuge Y.
  • Journal Title: Ann Nucl Med Volume: 27 Issue: 4 Pages: 355-362
  • DOI: 10.1007/s12149-013-0693-9
  • Peer Reviewed
• [Journal Article] 顎骨疾患における核医学応用の可能性. (2013)
  • Author(s): 北川善政、浅香卓哉、秦 浩信
  • Journal Title: PET Journal Volume: 22 Pages: 10-12
  • NAID: 40019753838
• [Presentation] MRONJに対する高気圧酸素療法(HBO)の応用とFDG- PETによる評価 (2016)
  • Author(s): 北川善政
  • Organizer: 第31回日本口腔科学会学術集会 シンポジウム
  • Place of Presentation: 福岡国際会議場（福岡県・福岡市）
  • Year and Date: 2016-04-15
  • Invited
• [Presentation] 望まれる医療人になるために － 臨床・研究・教育の視点から －． (2015)
  • Author(s): 犬伏正幸
  • Organizer: 日本放射線技術学会 中国・四国支部 第35回核医学夢工房
  • Place of Presentation: 岡山国際交流センター（岡山県・岡山市）
  • Year and Date: 2015-11-28
  • Invited
• [Presentation] Detailed assessment of gene activation levels by multiple hypoxia-responsive elements under various hypoxic conditions. (2015)
  • Author(s): Takeuchi Y, Inubushi M, Jin YN, Murai C, Tsuji AB, Hata H, Kitagawa Y, Saga T
  • Organizer: 日本核医学会学術総会 久田賞受賞講演
  • Place of Presentation: アットリージェンシー東京（東京都・新宿区）
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] FMISO-PET REFLECTS NOT ONLY HYPOXIA BUT ALSO CELL PROLIFERATION IN ORAL SQUAMOUS CELL CARCINOMA (2015)
  • Author(s): J. Sato, Y. Kitagawa, S. Watanabe, T. Asaka, N. Ohga, M. Miyakoshi, H. Hata, S. Okamoto, T. Shiga, M. Shindoh , N. Tamaki
  • Organizer: ICOM
  • Place of Presentation: Melbourne (Australia)
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] PETの素朴な疑問にお答えします． (2015)
  • Author(s): 犬伏正幸
  • Organizer: 第40回札幌核医学技術研究会
  • Place of Presentation: 北海道大学（北海道・札幌市）
  • Year and Date: 2015-10-23
  • Invited
• [Presentation] Clinical Value of FAZA-PET/CT in Head and Neck Cancer Patients. Annual Congress of the European Association of Nuclear Medicine 2015, Congress Center Hamburg, Hamburg, Germany. (2015)
  • Author(s): Saga T, Inubushi M, Koizumi M, Yoshikawa K, Zhang MR, Obata T, Harada R, Uno T.
  • Organizer: Annual Congress of the European Association of Nuclear Medicine 2015
  • Place of Presentation: Congress Center Hamburg, Hamburg (Germany)
  • Year and Date: 2015-10-14
  • Int'l Joint Research
• [Presentation] 医学教育環境のあるべき姿 (2015)
  • Author(s): 犬伏正幸
  • Organizer: 先端イメージング教育研究センター教育システム活用セミナー
  • Place of Presentation: 福井大学（福井県・福井市）
  • Year and Date: 2015-09-25
  • Invited
• [Presentation] Clinical value of FAZA-PET/CT in advanced lung cancer patients: comparison with FDG-PET/CT. (2015)
  • Author(s): Saga T, Inubushi M, Koizumi M, Yoshikawa K, Zhang MR, Horiike A, Kudo K, Ohyanagi F, Nishio M.
  • Organizer: World Molecular Imaging Congress 2015
  • Place of Presentation: Hawaii Convention Center, Honolulu, Hawaii (USA)
  • Year and Date: 2015-09-02
• [Presentation] 核医学（核医学総論）．教育セミナー (2015)
  • Author(s): 犬伏正幸
  • Organizer: 第124回日本医学放射線学会中国・四国地方会
  • Place of Presentation: 山口グランドホテル（山口県・山口市）
  • Year and Date: 2015-06-26
  • Invited
• [Presentation] Hypoxic volume evaluated by FMISO-PET reflects the expression of HIF-1α and Ki-67 in oral squamous cell carcinoma. (2015)
  • Author(s): Sato, Jun, Kitagawa, Yoshimasa, Watanabe, Shiro, Okamoto, Shozo, Noritaka, Ohga, Asaka, Takuya, Miyakoshi, Masaaki, Hata, Hironobu, Kenji Hirata , Hattori, Naoya, Shiga Tohru, Shindoh Masanobu, Tamaki Nagara
  • Organizer: The 62th Annual Meeting, Society of Nuclear Medicine and Molecular Imaging
  • Place of Presentation: Baltimore (USA)
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] Performance characteristics of a novel clustered multi-pinhole technology for simultaneous high-resolution SPECT/PET. (2015)
  • Author(s): Miwa K, Inubushi M, Takeuchi Y, Katafuchi T, Koizumi M, Saga T, Sasaki M.
  • Organizer: The 62th Annual Meeting, Society of Nuclear Medicine and Molecular Imaging
  • Place of Presentation: Baltimore (USA)
  • Year and Date: 2015-06-06
• [Presentation] Seamless quantitative assessments from whole body to cellular level for high dose radiation-induced mouse intestinal injury/rescue. (2015)
  • Author(s): Michikawa Y, Xu H, Fukuzaki T, Gotoh N, Tsukamoto S, Kito S, Shimomura T, Ohtake J, Takada M, Akiyama M, Suto Y, Matsuzaki Y, Inubushi M.
  • Organizer: The 15th International Congress of Radiation Research
  • Place of Presentation: Kyoto International Conference Center, Kyoto (Japan)
  • Year and Date: 2015-05-25
  • Int'l Joint Research
• [Presentation] Sorafenibの抗腫瘍効果の機序：腎細胞癌モデルにおける18F-fluoromisonidazole低酸素イメージングによる腫瘍内酸素状態の評価. (2014)
  • Author(s): 于 聞文
  • Organizer: 平成26年度北海道歯学会秋季学術大会
  • Place of Presentation: 北海道大学（北海道・札幌市）
  • Year and Date: 2014-11-28 – 2014-11-29
• [Presentation] 抗血管新生剤(sorafenib)の抗腫瘍効果の機序:腎細胞癌モデルにおける18F-FMISOによる腫瘍内酸素状態の評価. (2014)
  • Author(s): 于 聞文、趙 松吉、趙 芫 、ファティマ チョウドリ ヌスラット、西嶋 剣一、北川 善政、玉木 長良、久下 裕司
  • Organizer: 第54回日本核医学学術総会
  • Place of Presentation: 大阪国際会議場（大阪府・大阪市）
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] FDG-PETを用いたビスフォスフォネート関連顎骨壊死に対する高圧酸素療法の有効性の評価 (2014)
  • Author(s): 浅香卓哉、 秦浩信、宮腰昌明、佐藤明、佐藤淳、北川善政
  • Organizer: 第59回日本口腔外科学会総会
  • Place of Presentation: 幕張メッセ（千葉県・千葉市）
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] Changes in tumor oxygen states after sorafenib therapy evaluated by using 18F-fluoromisonidazole hypoxia imaging in a renal cell carcinoma xenograft. (2014)
  • Author(s): Wenwen Yu, Songji Zhao, Yan Zhao, Chowdhury Nusrat Fatema, Masahiro Murakami, Ken-ichi Nishijima, Yoshimasa Kitagawa, Nagara Tamaki, Yuji Kuge
  • Organizer: 2014 World Molecular Imaging Congress
  • Place of Presentation: Seoul (South Korea)
  • Year and Date: 2014-09-17 – 2014-09-20
• [Presentation] マルチキナーゼ阻害剤sorafenibの抗腫瘍効果の機序:腎細胞癌モデルにおける18F-FMISOによる腫瘍内酸素状態の評価. (2014)
  • Author(s): 于 聞文、趙 松吉、趙 芫 、ファティマ チョウドリ ヌスラット、西嶋 剣一、北川 善政、玉木 長良、久下 裕司
  • Organizer: 第14回放射線医薬品・画像診断薬研究会
  • Place of Presentation: 京都勧業館（京都府・京都市）
  • Year and Date: 2014-09-13
• [Presentation] Advantage of FMISO-PET over FDG-PET for predicting histological response to preoperative chemotherapy in patients with oral squamous cell carcinoma (2014)
  • Author(s): Jun Sato, Yoshimasa Kitagawa, Yutaka Yamazaki, Hironobu Hata, Takuya Asaka, Masaaki Miyakoshi, Masanobu Shindoh
  • Organizer: AAOMS 96th Annual Meeting
  • Place of Presentation: Hawaii (USA)
  • Year and Date: 2014-09-08 – 2014-09-13
• [Presentation] The Usefulness of FDG-PET for Monitoring Hyperbaric Oxygen Therapy in Treatment of Bisphosphonate-Related Osteonecrosis of Jaws (BRONJ) (2014)
  • Author(s): Takuya Asaka, Hironobu Hata, Jun Sato, Akira Satoh, Masaaki Miyakoshi, Yoshimasa
  • Organizer: AAOMS 96th Annual Meeting
  • Place of Presentation: Hawaii (USA)
  • Year and Date: 2014-09-08 – 2014-09-13
• [Presentation] FMISO-PET reflects the ability of cell proliferation in oral squamous cell carcinoma (2014)
  • Author(s): Sato Jun, Kitagawa Yoshimasa, Yamazaki Yutaka, Hata Hironobu, Miyakoshi Masaaki, Asaka Takuya, Noritaka Ohga, Hattori Naoya, Okamoto Shozo, Shiga Tohru, Shindoh Masanobu, Tamaki Nagar
  • Organizer: The 12th international symposium for future drug discovery and medical care
  • Place of Presentation: 北海道大学（北海道・札幌市）
  • Year and Date: 2014-09-04 – 2014-09-05
• [Presentation] FMISO-PET reflects the ability of cell proliferation in oral squamous cell carcinoma. (2014)
  • Author(s): Sato J, Kitagawa Y, Yamazaki Y, Hata H, Miyakoshi M, Asaka T, Hattori N, Okamoto S, Shiga T, Shindoh M, Tamaki N
  • Organizer: 61st Annual Meeting Society of Nuclear Medicine and Molecular Imaging (SNMMI)
  • Place of Presentation: St. Louis (USA)
  • Year and Date: 2014-06-07 – 2014-06-12
• [Presentation] Simultaneous PET/SPECT imaging to compare tumor uptake level of 18F-FMISO with 64Cu-ATSM on the basis of the genetic activation level responding to tumor hypoxia (2014)
  • Author(s): Takeuchi Y, Inubushi M, Jin YN, Murai C, Xu H, Mio K, Hata H, Kitagawa Y, Saga T.
  • Organizer: 61st Annual Meeting Society of Nuclear Medicine and Molecular Imaging (SNMMI)
  • Place of Presentation: St. Louis (USA)
  • Year and Date: 2014-06-07 – 2014-06-12
• [Presentation] Mechanisms of anti-tumor effects underlying sorafenib treatment: evaluation of tumor oxygen states using 18F-FMISO in a human lung cancer xenograft (2014)
  • Author(s): Yu W, Zhao S, Zhao Y, Fatema CN, Murakami M, Nishijima K, Kitagawa Y, Tamaki N, Kuge Y.
  • Organizer: 61st Annual Meeting Society of Nuclear Medicine and Molecular Imaging
  • Place of Presentation: St. Louis (USA)
  • Year and Date: 2014-06-07 – 2014-06-12
• [Presentation] 腫瘍内の低酸素遺伝子応答と低酸素PETトレーサー集積の関係 (2014)
  • Author(s): 竹内康人、犬伏正幸、村井知佳、秦浩信、北川善政、佐賀恒夫
  • Organizer: 日本分子イメージング学会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府・豊中市）
  • Year and Date: 2014-05-22 – 2014-05-23
• [Presentation] さまざまな低酸素条件における低酸素応答領域による遺伝子発現の評価 (2014)
  • Author(s): 竹内康人、犬伏正幸、村井知佳、秦浩信、北川善政
  • Organizer: 日本口腔科学会
  • Place of Presentation: 京王プラザホテル（東京都・新宿区）
  • Year and Date: 2014-05-08 – 2014-05-09
• [Presentation] Preoperative detection of Neck lymph node metastasis using FDG-PET/CT (2014)
  • Author(s): Miyakoshi M, Murai C, Abe T, Hata H, Sato A, Yamazaki Y, Kitagawa Y, Shiga T, Tamaki N
  • Organizer: FRONTIERS IN ORAL MEDICINE ORLANDO 2014 (AAOM2014)
  • Place of Presentation: Orlando (USA)
  • Year and Date: 2014-04-09 – 2014-04-12
• [Presentation] FDG-PET and 3-phase bone scintigraphy to differentiate diffuse sclerosing osteomyelitis from other refractory chronic osteomyelitis of jaws (2013)
  • Author(s): Kitagawa Y, Asaka T, Hata H, Sato Jun, Yamazaki Y, Okamoto S, Hattori N, Shiga T, Tamaki N
  • Organizer: 60th Annual Meeting Society of Nuclear Medicine and Molecular Imaging (SNMMI)
  • Place of Presentation: Vancouver (Canada)
• [Presentation] FMISO-PET predicts the pre-operative chemotherapy response in patients with oral squamous cell carcinoma. (2013)
  • Author(s): Sato J, Kitagawa Y, Yamazaki Y, Hata H, Asaka T, Hattori N, Okamoto S, Shiga T, Shindoh M, Tamaki N
  • Organizer: 60th Annual Meeting Society of Nuclear Medicine and Molecular Imaging (SNMMI)
  • Place of Presentation: Vancouver (Canada)
• [Presentation] Sequential evaluation of intratumoral proliferative activity after radiotherapy by FLT in human head and neck cancer xenograft. (2013)
  • Author(s): Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima K, Kitagawa Y, Tamaki N, Kuge Y
  • Organizer: 60th Annual Meeting Society of Nuclear Medicine and Molecular Imaging (SNMMI)
  • Place of Presentation: Vancouver (Canada)
• [Presentation] Comparison of intratumoral distribution of 18F-FMISO and 64Cu-ATSM with regions genetically responding to hypoxia by quantitative cluster analyses (2013)
  • Author(s): Takeuchi Y, Inubushi M, Yong-Nan Jin, Murai C, Xu H, Mio K, Hata H, Kitagawa Y, Saga T
  • Organizer: 60th Annual Meeting Society of Nuclear Medicine and Molecular Imaging (SNMMI)
  • Place of Presentation: Vancouver (Canada)
• [Presentation] FDG-PET to monitor hyperbaric oxygen therapy for bisphosphonate-related osteonecrosis of jaws (BRONJ) (2013)
  • Author(s): Asaka T, Kitagawa Y, Yamazaki Y, Hata H, Sato J, Hattori N, Okamoto S, Shiga T, Tamaki N
  • Organizer: 60th Annual Meeting Society of Nuclear Medicine and Molecular Imaging (SNMMI)
  • Place of Presentation: Vancouver (Canada)
• [Presentation] Differential diagnosis of intraosseous malignancies of the mandible by FDG-PET/CT (2013)
  • Author(s): Asaka T, Kitagawa Y, Yamazaki Y, Hata H, Sato J, Hattori N, Okamoto S, Shiga T, Tamaki N
  • Organizer: 60th Annual Meeting Society of Nuclear Medicine and Molecular Imaging (SNMMI)
  • Place of Presentation: Vancouver (Canada)
• [Presentation] Sequential evaluation of tumor proliferative activity after radiotherapy using FLT in human head and neck cancer xenograft: comparison with Ki-67. (2013)
  • Author(s): Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima K, Kitagawa Y, Tamaki N, Kuge Y
  • Organizer: The 67th Annual Meeting of the Japanese Stomatological Society
  • Place of Presentation: Utsunomiya (Tochigi)
• [Presentation] FDG-PETは口腔扁平上皮癌患者の術前化学療法の組織学的効果を反映する. (2013)
  • Author(s): 佐藤 淳、山崎 裕、北川善政、他
  • Organizer: 第67回日本口腔科学会総会 優秀ポスタ－賞受賞
  • Place of Presentation: 宇都宮
• [Presentation] FMISO-PETは口腔扁平上皮癌の低酸素状態のみならず細胞増殖能を反映する. (2013)
  • Author(s): 佐藤 淳、山崎 裕、北川善政、他
  • Organizer: 58回日本口腔外科学会総会・学術大会 優勝ポスタ－賞受賞
  • Place of Presentation: 福岡
• [Presentation] 腫瘍内の低酸素遺伝子応答と低酸素PETトレーサ集積の関係 (2013)
  • Author(s): 竹内康人、犬伏正幸、村井知佳、秦浩信、北川善政、佐賀恒夫
  • Organizer: 第53回 日本核医学会学術総会
  • Place of Presentation: 福岡国際会議場〔福岡）
• [Presentation] FDG-PET/CTを用いた口腔癌術前頸部リンパ節転移検出に関する検討
  • Author(s): 宮腰昌明、村井知佳、阿部貴洋、秦 浩信、佐藤 明、山崎 裕、北川善政
  • Organizer: 第53回 日本核医学会学術総会
  • Place of Presentation: 福岡国際会議場〔福岡）