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Development of the method for bone regeneration mimicing distraction osteogenesis for extensive bone defects without distraction devices

Research Project

Project/Area Number 25293408
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionNagoya University

Principal Investigator

HIBI Hideharu  名古屋大学, 医学(系)研究科(研究院), 教授 (90345885)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Akihito  名古屋大学, 大学院医学系研究科, 准教授 (50244083)
KURODA Kensuke  名古屋大学, 未来材料・システム研究所, 准教授 (00283408)
KATAGIRI Wataru  名古屋大学, 大学院医学系研究科, 講師 (10437030)
HATTORI Hisashi  名古屋大学, 医学部附属病院, 講師 (60332699)
TSUCHIYA Shuhei  名古屋大学, 医学部附属病院, 助教 (20569785)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywords移植・再生医療 / 再生医学 / 骨再生 / 幹細胞培養上清
Outline of Final Research Achievements

The components of the conditioned media collected from bone marrow mesenchymal stem cells and dental pulp stem cells were detected and partially quantified. We showed that the conditioned media enhanced cell adhesion ability, cell migration ability, angiogenic potential, anti-inflammatory action and anti-apoptotic effect, and that the conditioned media from hypoxic-cultured cells further enhanced the cell migration ability and the angiogenic potential in vitro. We also showed that the conditioned media promoted vascular network formation and consequent bone regeneration, and that the conditioned media from hypoxic-cultured cells further promoted this process in vivo.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (49 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (16 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 16 results,  Open Access: 8 results,  Acknowledgement Compliant: 6 results) Presentation (31 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results)

  • [Int'l Joint Research] University of Bergen(Norway)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Factors secreted from dental pulp stem cells show multifaceted benefits for treating experimental rheumatoid arthritis.2016

    • Author(s)
      Ishikawa J, Takahashi N, Matsumoto T, Yoshioka Y, Yamamoto N, Nishikawa M, Hibi H, Ishigro N, Ueda M, Furukawa K, Yamamoto A.
    • Journal Title

      Bone.

      Volume: 83 Pages: 210-219

    • DOI

      10.1016/j.bone.2015.11.012

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CD109 is a component of exosome secreted from cultured cells2016

    • Author(s)
      Sakakura H, Mii S, Hagiwara S, Kato T, Yamamoto N, Hibi H, Takahashi M, Murakumo Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 469 Issue: 4 Pages: 816-822

    • DOI

      10.1016/j.bbrc.2015.12.063

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical review of bone regenerative medicine and maxillomandibular reconstruction2016

    • Author(s)
      Hibi H
    • Journal Title

      Oral Science International

      Volume: 13 Issue: 1 Pages: 15-19

    • DOI

      10.1016/s1348-8643(15)00037-3

    • NAID

      130005137546

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells2016

    • Author(s)
      Katagiri W, Osugi M, Kawai T, Hibi H
    • Journal Title

      Head & Face Medicine

      Volume: 12 Issue: 1 Pages: 5-5

    • DOI

      10.1186/s13005-016-0101-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new application of cell-free bone regeneration: Immobilizing stem cells from human exfoliated deciduous teeth-conditioned medium onto titanium implants by using atmospheric pressure plasma treatment2015

    • Author(s)
      Masahiro Omori, Shuhei Tsuchiya, Kenji Hara, Kensuke Kuroda, Hideharu Hibi, Masazumi Okido and Minoru Ueda
    • Journal Title

      Stem Cell Research & Therapy

      Volume: 6 Issue: 1 Pages: 124-136

    • DOI

      10.1186/s13287-015-0114-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Peripheral nerve regeneration by secretomes of stem cells from human exfoliated deciduous teeth2015

    • Author(s)
      Sugimura-Wakayama Y, Katagiri W, Osugi M, Kawai T, Ogata K, Sakaguchi K, Hibi H
    • Journal Title

      Stem Cells and Development

      Volume: 24 Issue: 22 Pages: 2687-2699

    • DOI

      10.1089/scd.2015.0104

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of alzheimer’s disease.2015

    • Author(s)
      Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, Ueda M, Yamamoto A.
    • Journal Title

      Behav Brain Res.

      Volume: 293 Pages: 189-197

    • DOI

      10.1016/j.bbr.2015.07.043

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] An experimental study on guided bone regeneration by using a polylactide-co-glycolide membrane-immobilized conditioned medium2015

    • Author(s)
      Tsuchiya S, Omori M, Hara K, Fujio M, Ikeno M, Hibi H, Ueda M
    • Journal Title

      International Journal of Oral and Maxillofacial Implants

      Volume: 30 Issue: 5 Pages: 1175-86

    • DOI

      10.11607/jomi.3915

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Secreted Frizzled-Related Protein Promotes Bone Regeneration by Human Bone Marrow-Derived Mesenchymal Stem Cells2015

    • Author(s)
      Katagiri W, Osugi M, Kawai T, Hibi H
    • Journal Title

      International Journal of Molecular Science

      Volume: 16 Issue: 10 Pages: 23250-23258

    • DOI

      10.3390/ijms161023250

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Conditioned medium from mesenchymal stem cells enhances early bone regeneration after maxillary sinus floor elevation in rabbits2015

    • Author(s)
      Katagiri W, Osugi M, Kinoshita K, Hibi H
    • Journal Title

      Implant dentistry

      Volume: 24 Issue: 6 Pages: 657-663

    • DOI

      10.1097/id.0000000000000335

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Secreted factors from dental pulp stem cells improve glucose intolerance in streptozotocin-induced diabetic mice by increasing pancreatic β-cell function2015

    • Author(s)
      Izumoto-Akita T, Tsunekawa S, Yamamoto A, Uenishi E, Ishikawa K, Ogata H, Iida A, Ikeniwa M, Hosokawa K, Niwa Y, Maekawa R, Yamauchi Y, Seino Y, Hamada Y, Hibi H, Arima H, Ueda M, Oiso Y
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 3 Issue: 1 Pages: e000128-e000128

    • DOI

      10.1136/bmjdrc-2015-000128

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dental pulp-derived stem cell conditioned medium reduces cardiac injury following ischemia-reperfusion2015

    • Author(s)
      Yamaguchi S, Shibata R, Yamamoto N, Nishikawa M, Hibi H, Tanigawa T, Ueda M, Murohara T, Yamamoto A
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16295-16295

    • DOI

      10.1038/srep16295

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conditioned media from hypoxic-cultured human dental pulp cells promotes bone healing during distraction osteogenesis2015

    • Author(s)
      Fujio M, Xing Z, Sharabi N, Xue Y, Yamamoto A, Hibi H, Ueda M, Fristad I, Mustafa K
    • Journal Title

      Journal of Tissue Engineering and Regenerative Medicine

      Volume: Epub ahead of print Issue: 7 Pages: 230-240

    • DOI

      10.1002/term.2109

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Secretomes from bone marrow-derived mesenchymal stromal cells enhance periodontal tissue regeneration2015

    • Author(s)
      Kawai, T., Katagiri, W., Osugi, M., Sugimura, Y., Hibi, H., Ueda, M.
    • Journal Title

      Cytotherapy

      Volume: 17 Issue: 4 Pages: 369-381

    • DOI

      10.1016/j.jcyt.2014.11.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model2015

    • Author(s)
      Ogata, K., Katagiri, W., Osugi, M., Kawai, T., Sugimura, Y., Hibi, H., Nakamura, S., Ueda, M.
    • Journal Title

      Bone

      Volume: 74 Pages: 95-105

    • DOI

      10.1016/j.bone.2015.01.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stem cell-conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms2014

    • Author(s)
      Ando K, Matsubara K, Ishikawa J, Fujio M, Shohara R, Hibi H, Ueda M, Yamamoto A
    • Journal Title

      Bone

      Volume: 61 Pages: 82-90

    • DOI

      10.1016/j.bone.2013.12.029

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨髄由来間葉系幹細胞培養上清由来液性因子を用いた新たな骨再生治療に関する臨床的検討2016

    • Author(s)
      外山直人,片桐渉,大杉将嗣,安藤さやか,若山有紀子,坂口晃平,鶴田剛士,渡邊純奈,日比英晴
    • Organizer
      第15回日本再生医療学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] イヌ歯周病モデルを用いた成長因子混合剤による歯周組織再生能の検討2016

    • Author(s)
      坂口晃平,片桐渉,大杉将嗣,若山有紀子,鶴田剛士,日比英晴
    • Organizer
      第15回日本再生医療学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Conditioned media from bone marrow derived mesenchymal stem cells enhances bone regeneration in rat calvarial bone defects2016

    • Author(s)
      Osugi M, Katagiri W, Sakaguchi K, Kawai T, Hibi H
    • Organizer
      Annual Meeting of Academy of Osseointegration
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-02-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical study for bone regeneration after maxillary sinus floor elevation by secretomes from mesenchymal stem cells2016

    • Author(s)
      Katagiri W, Osugi M, Watanabe J, Sakaguchi K, Hibi H
    • Organizer
      Annual Meeting of Academy of Osseointegration
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-02-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト歯髄幹細胞無血清培養上清を用いた関節炎モデルマウスにおける治療効果の検討2015

    • Author(s)
      石川純,山本憲幸,西川雅也,若山博隆,山口聡,日比英晴,山本朗仁
    • Organizer
      第60回日本口腔外科学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 幹細胞培養上清由来液性因子を用いた新規骨再生医療における組織学的検討2015

    • Author(s)
      渡邊純奈,片桐渉,大杉将嗣,安藤さやか,椙村有紀子,緒方謙一,坂口晃平,鶴田剛士,日比英晴
    • Organizer
      第60回日本口腔外科学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒト歯髄幹細胞無血清培養上清を用いた関節炎モデルマウスにおける治療効果の検討2015

    • Author(s)
      石川純,高橋伸典,山本憲幸,西川雅也,若山博隆,山口聡,日比英晴,石黒直樹,山本朗仁
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      虎の門ヒルズフォーラム(東京都港区)
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 成長因子混合剤による新たな骨再生法2015

    • Author(s)
      坂口晃平,片桐渉,大杉将嗣,河合孝真,椙村有紀子,緒方謙一,日比英晴
    • Organizer
      第14回日本再生医療学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラットBRONJ様モデルにおける幹細胞培養上清による治療効果の検討2015

    • Author(s)
      緒方謙一,片桐渉,大杉将嗣,河合孝真,椙村有紀子,坂口晃平,日比英晴,中村誠司,上田実
    • Organizer
      第14回日本再生医療学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel Bone Regenerative Medicine Using the Secretomes From Bone Marrow-derived Mesenchymal Stem Cells2015

    • Author(s)
      Katagiri, W., Sugimura, Y., Osugi, M., Kawai, T., Ogata, K., Sakaguchi, K., Hibi, H
    • Organizer
      IADR/AADR/CADR General Session
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Conditioned Media From SHED Enhanced Peripheral Nerve Regeneration2015

    • Author(s)
      Sugimura, Y., Katagiri, W., Osugi, M., Kawai, T., Ogata, K., Sakaguchi, K., Hibi, H.
    • Organizer
      IADR/AADR/CADR General Session
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラットBRONJ様モデルにおける幹細胞培養上清由来液性因子による治療効果の検討2014

    • Author(s)
      緒方謙一,片桐渉,大杉将嗣,河合孝真,椙村有紀子,坂口晃平,日比英晴,中村誠司,上田実
    • Organizer
      第59回日本口腔外科学会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大気圧プラズマ処理したチタンインプラントへのヒト脱落乳歯幹細胞由来培養上清の応用2014

    • Author(s)
      大森正裕,土屋周平,原憲史,藤尾正人,西野雄大,杉本圭佑,日比英晴,上田実
    • Organizer
      第59回日本口腔外科学会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 乳歯歯髄幹細胞を用いた末梢神経再生治療の可能性2014

    • Author(s)
      椙村有紀子,片桐渉,大杉将嗣,河合孝真,緒方謙一,坂口晃平,日比英晴,上田実
    • Organizer
      第59回日本口腔外科学会
    • Place of Presentation
      幕張メッセ(千葉県千葉市)
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in rat bisphosphonate-related osteonecrosis of the jaw model2014

    • Author(s)
      Ogata, K., Katagiri, W., Osugi, M., Kawai, T., Sugimura, Y., Sakaguchi, K., Hibi, H., Nakamura, S., Ueda, M.
    • Organizer
      23rd Annual Scientific Meeting of European Association for Osseointegration
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Novel strategy of bone regeneration with the cocktail of recombinant cytokines mimicking secretomes derived from mesenchymal stem cells2014

    • Author(s)
      Sakaguchi, K., Katagiri, W., Osugi, M., Kawai, T., Sugimura, Y., Ogata, K., Hibi, H., Ueda, M.
    • Organizer
      23rd Annual Scientific Meeting of European Association for Osseointegration
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト骨髄由来間葉系幹細胞の無血清培養上清による多面的な骨延長治癒促進効果の検討2014

    • Author(s)
      安藤友二,山本朗仁,松原弘記,石川純,藤尾正人,匠原龍太郎,日比英晴,上田実
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Year and Date
      2014-07-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] ラットBRONJ様モデルにおける幹細胞培養上清による治療効果の検討2014

    • Author(s)
      緒方謙一,片桐渉,大杉将嗣,河合孝真,椙村有希子,坂口晃平,日比英晴,中村誠司,上田実
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Year and Date
      2014-07-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大気圧プラズマによるチタンの親水化機能表面作製とヒト脱落乳歯幹細胞由来培養上清による骨結合の向上2014

    • Author(s)
      大森正裕,土屋周平,原憲史,黒田健介,日比英晴,興戸正純,上田実
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Year and Date
      2014-07-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 幹細胞培養上清を模した成長因子複合剤による新たな骨再生法2014

    • Author(s)
      坂口晃平,片桐渉,大杉将嗣,河合孝真,椙村有希子,緒方謙一,日比英晴,上田実
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Year and Date
      2014-07-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 骨髄由来間葉系幹細胞培養上清による歯周組織再生2014

    • Author(s)
      河合孝真,片桐渉,大杉将嗣,椙村有希子,緒方謙一,坂口晃平,日比英晴,上田実
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      万国津梁館(沖縄県名護市)
    • Year and Date
      2014-07-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] オッセオインテグレーション早期獲得のためのインプラントへの細胞培養上清の応用2014

    • Author(s)
      土屋周平,日比英晴,上田実
    • Organizer
      第123回日本補綴歯科学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 顎骨再建についての再生医学的検討2014

    • Author(s)
      日比英晴
    • Organizer
      第68回日本口腔科学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-05-09
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Invited
  • [Presentation] 幹細胞培養上清由来成長因子による骨再生における血管新生2013

    • Author(s)
      河合孝真,片桐渉,大杉将嗣,椙村有紀子,緒方謙一,日比英晴,中村誠司,上田実
    • Organizer
      第34回日本炎症・再生医学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Using hDPCs culture environments affect regenerative potential of conditioned media2013

    • Author(s)
      Fujio M, Sharabi NA, Xing Z, Xue Y, Yamamoto A, Hibi H, Ueda M, Fristad I, Mustafa KBE
    • Organizer
      46th Meeting of the Continental European Division of the International Association for Dental Research with the Scandinavian Division
    • Place of Presentation
      Florence, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨髄間葉系幹細胞の無血清培養上清による骨延長の仮骨形成促進効果2013

    • Author(s)
      安藤友二,山本朗仁,藤尾正人,日比英晴,上田実
    • Organizer
      第43回日本口腔インプラント学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] SDF-1の局所投与による骨再生促進効果の検討2013

    • Author(s)
      石川純,山本朗仁,匠原龍太郎,日比英晴,上田実
    • Organizer
      第43回日本口腔インプラント学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 幹細胞培養上清由来液性因子による内在性細胞の遊走および血管新生を先行させる新たな骨再生法2013

    • Author(s)
      片桐渉,大杉将嗣,匠原龍太郎,日比英晴,上田実
    • Organizer
      第43回日本口腔インプラント学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 複数のサイトカイン群による血管新生を伴う新たな骨再生法2013

    • Author(s)
      片桐渉,大杉将嗣,河合孝真,椙村有希子,緒方謙一,日比英晴,上田実
    • Organizer
      第58回日本口腔外科学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨髄由来間葉系幹細胞由来液性因子による歯周組織再生2013

    • Author(s)
      坂口晃平,片桐渉,河合孝真,大杉将嗣,椙村有希子,緒方謙一,日比英晴,上田実
    • Organizer
      第58回日本口腔外科学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨髄由来間葉系幹細胞由来液性因子による骨再生における血管新生2013

    • Author(s)
      大杉将嗣,片桐渉,河合孝真,椙村有希子,緒方謙一,日比英晴,上田実
    • Organizer
      第58回日本口腔外科学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Annual Research Report
  • [Book] Micro-Nano Mechatronics; New Trends in Material, Measurement, Control, Manufacturing and Their Applications in Biomedical Engineering2013

    • Author(s)
      Hibi H, Ueda M
    • Total Pages
      364
    • Publisher
      InTech
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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