| Project/Area Number |
25293409
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
KOGO MIKIHIKO 大阪大学, 歯学研究科(研究院), 教授 (20205371)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
田中 晋 大阪大学, 歯学部附属病院, 講師 (00367541)
辻 忠孝 大阪大学, 歯学研究科(研究院), 招聘教員 (50527231)
宮川 和晃 大阪大学, 歯学部附属病院, 医員 (50635381)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO TAKASHI 畿央大学, 健康科学部, 教授 (60028793)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
|
|---|
| Keywords | 口腔感覚 / 三叉神経 / 摂食促進ペプチド |
|---|
| Outline of Final Research Achievements |
Zinc-deficient (ZD) rats at 8 weeks age ate larger amount of pellets during daytime as well as nighttime together with short latency to initial eating and small number of bouts, indicating that the ZD rats seem to have a large appetite despite daytime. Interestingly, switching to normal diets (ND) in the ZD rats for one week caused a decrease of the amount of food intake and an extension of the latency to eat in the daytime, as shown in rats fed by ND. These results indicated that the effects of zinc-deficient feeding on the characteristics of feeding behavior are reversible. In addition, mesencephalic trigeminal neurons (MTNs) in ZD rats demonstrated depolarized resting membrane potential and decreased rheobase for eliciting single spike or spike train accompanying with hastened spike repolarization, which resulted in increased spike frequency and membrane excitabilities in comparison with MTNs in ND rats.
|
