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Roles of extracellular matrices in TMJ disordres -response properties of TMJ disc to mechanical stress

Research Project

Project/Area Number 25293421
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

Mizoguchi itaru  北海道医療大学, 歯学部, 教授 (20200032)

Co-Investigator(Kenkyū-buntansha) 鳥谷 奈保子  北海道医療大学, 歯学部, 助教 (20433435)
岡山 三紀  北海道医療大学, 歯学部, 助教 (30382500)
田隈 泰信  北海道医療大学, 歯学部, 教授 (40095336)
荒川 俊哉  北海道医療大学, 歯学部, 准教授 (40306254)
今野 萌  北海道医療大学, 歯学部, 助手 (90634072)
中尾 友也  北海道医療大学, 歯学部, 研究員 (90733048)
樫尾 治奈  北海道医療大学, 歯学部, その他 (70779222)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords関節円板 / 細胞外基質 / プロテオグリカン / コラーゲン / タンパク質発現 / mRNA発現 / 顎関節 / 顎関節症 / 機械的刺激 / たんぱく質発現 / 機械的荷重 / 機械的負荷 / mRNA / タンパク質
Outline of Final Research Achievements

In vivo study showed that GAG content, mRNA and protein levels of decorin, biglycan,versican and condoroadherin increased in response to increased joint loading. In vitro study indicated that the mRNA levels of versican, aggrecan fibromodulin and type I collagen increased in response to stretching, while the decorin mRNA levels of lumican, decorin and tropoelastin decreased. These results indicate that mechanical stress cause complicated changes in extracellular matrix components in TMJ disc.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (36 results)

All 2017 2016 2015 2014 2013

All Journal Article (18 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 18 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (18 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Cementocyte cell death occurs in rat cellular cementum during orthodontic tooth movemen2017

    • Author(s)
      Matsuzawa H, Toriya N, Nakao Y, Konno-Nagasaka M, Arakawa T, Okayama M, Mizoguchi I
    • Journal Title

      Angle Orthod

      Volume: 87 Issue: 3 Pages: 416-422

    • DOI

      10.2319/071116-541.1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Three-dimensional Morphological Characteristics of the Mandibular Condyles in Cases of Facial Asymmetry2016

    • Author(s)
      笹本さえら、上地 潤、今野正裕、溝口 到
    • Journal Title

      The Japanese Journal of Jaw Deformities

      Volume: 26 Issue: 4 Pages: 255-265

    • DOI

      10.5927/jjjd.26.255

    • NAID

      130005286426

    • ISSN
      0916-7048, 1884-5045
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CO2レーザー照射とグラスアイオノマーセメントによる象牙質の再石灰化2016

    • Author(s)
      飯嶋雅弘、伊藤修一、川村尚彦、斎藤 隆史、溝口 到
    • Journal Title

      日本レーザー歯科学会雑誌

      Volume: 27 Pages: 101-107

    • NAID

      130005290130

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of the coatings covering esthetic orthodontic archwires and their influence on the bending and frictional properties2016

    • Author(s)
      Muguruma T, Iijima M, Yuasa T, Kawaguchi K, Mizoguchi I.
    • Journal Title

      Angle Orthod

      Volume: 87 Issue: 4 Pages: 1-7

    • DOI

      10.2319/022416-161.1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of chitosan fiber addition on the properties of polyurethane with thermo-responsive shape memory2016

    • Author(s)
      Kawaguchi K, Iijima M, Miyakawa H, Ohta M, Muguruma T, Endo K, Nakazawa F, Mizoguchi I
    • Journal Title

      J Biomed Mater Res B Appl Biomater

      Volume: 2017 Issue: 5 Pages: 1-6

    • DOI

      10.1002/jbm.b.33664

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-cycle fatigue behavior of beta-titanium orthodontic wires2015

    • Author(s)
      Murakami T, Iijima M, Muguruma T, Yano F, Kawashima I, Mizoguchi I.
    • Journal Title

      Dental Materials Journal

      Volume: 34 Issue: 2 Pages: 189-195

    • DOI

      10.4012/dmj.2014-012

    • NAID

      130005062398

    • ISSN
      0287-4547, 1881-1361
    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of temperature changes and stress loading on the mechanical and shape memory properties of thermoplastic materials with different glass transition behaviours and crystal structures.2015

    • Author(s)
      Iijima M, Kohda N, Kawaguchi K, Muguruma T, Ohta M, Naganishi A, Murakami T, Mizoguchi I.
    • Journal Title

      Eur J Orthod

      Volume: 37 Issue: 6 Pages: 23-25

    • DOI

      10.1093/ejo/cjv013

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of enamel demineralization and bond-strength properties of bioactive glass containing 4-META/MMA-TBB-based resin adhesive.2015

    • Author(s)
      Kohda N, Iijima M, Kawaguchi K, Toshima H, Muguruma T, Endo K, Mizoguchi I
    • Journal Title

      Eur J Oral Sci.

      Volume: 123 Issue: 3 Pages: 202-207

    • DOI

      10.1111/eos.12187

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of standardization on the precision (reproducibility) of dental cast analysis with virtual 3-dimensional models.2015

    • Author(s)
      Kazuo Hayashi, Onejune Chung, Seojung Park, Seung-Pyo Lee, Iraru Mizoguchi
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics

      Volume: 147 Issue: 3 Pages: 373-380

    • DOI

      10.1016/j.ajodo.2014.11.015

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo degradation of orthodontic miniscrew implants: surface analysis of as-received and retrieved specimens.2015

    • Author(s)
      Iijima M, Muguruma T, Kawaguchi M, Yasuda Y, Mizoguchi I.
    • Journal Title

      J Mater Sci Mater Med

      Volume: 26 Issue: 2 Pages: 71-71

    • DOI

      10.1007/s10856-015-5405-7

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Generation of virtual models for planning orthognathic surgery using a modified multimodal image fusion technique.2015

    • Author(s)
      Uechi J, Tsuji Y, Konno M, Hayashi K, Shibata T, Nakayama E, Mizoguchi I.
    • Journal Title

      Int J Oral Maxillofac Surg.

      Volume: 44(4) Issue: 4 Pages: 462-469

    • DOI

      10.1016/j.ijom.2014.11.007

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteoglycan expression is influenced by mechanical load in TMJ discs.2015

    • Author(s)
      Nakao Y, Konno-Nagasaka M, Toriya N, Arakawa T, Kashio H, Takuma T, Mizoguchi I.
    • Journal Title

      J Dent Res

      Volume: 94 Issue: 1 Pages: 93-100

    • DOI

      10.1177/0022034514553816

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of immersion in solution of an experimental toothpaste containing S-PRG filler on like-remineralizing ability of etched enamel.2014

    • Author(s)
      Iijima M, Ito S, Nakagaki S, Kohda N, Muguruma T, Saito T, Mizoguchi I.
    • Journal Title

      Dent Mater J

      Volume: 33 Pages: 430-436

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of third-order torque on frictional force of self-ligating brackets2014

    • Author(s)
      Muguruma T, Iijima M, Brantley WA, Ahluwalia KS, Kohda N, Mizoguchi I
    • Journal Title

      Angle Orthodontist

      Volume: 84 Issue: 6 Pages: 1054-1061

    • DOI

      10.2319/111913-845.1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] VAMP4 is required to maintain the ribbon structure of the Golgi apparatus.2013

    • Author(s)
      Shitara A, Shibui T, Okayama M, Arakawa T, Mizoguchi I, Sakakura Y, Takuma T.
    • Journal Title

      Mol Cell Biochem.

      Volume: 380 Issue: 1-2 Pages: 11-21

    • DOI

      10.1007/s11010-013-1652-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of the accuracy and reliability of new 3-dimensional scanning devices2013

    • Author(s)
      Hayashi K, Sachdeva A, Saitoh S, Lee SP, Kubota T, Mizoguchi I
    • Journal Title

      Am J Orthod Dentofacial Orthop

      Volume: 144 Issue: 4 Pages: 619-625

    • DOI

      10.1016/j.ajodo.2013.04.021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth of the mandible and biological characteristics of the mandibular condylar cartilage2013

    • Author(s)
      Mizoguchi I, Toriya N, Nakao Y
    • Journal Title

      Jpn Dent Sci Rev

      Volume: 49 Pages: 139-150

    • NAID

      50009115438

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gravity loading induces adenosine triphosphate release and phosphorylation of extracellular signal-regulated kinases inhuman periodontal ligament cells2013

    • Author(s)
      Mai Ito, Toshiya Arakawa, Miki Okayama, Akiko Shitara, Itaru Mizoguchi, Taishin Takuma
    • Journal Title

      Journal of Investigative and Clinical Dentistry

      Volume: 4 Issue: 4 Pages: 1-9

    • DOI

      10.1111/jicd.12049

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] バイオアクティブガラスを添加した4-META/MMA-TBBレジン接着材料のエナメル質再石灰化能2016

    • Author(s)
      河口馨太朗、飯嶋雅弘、川村尚彦、六車武史、溝口 到
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      徳島県、徳島市、アスティとくしま
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 思春期skeletal ClassⅢ不正咬合症例にスケルタルアンカレッジを用いて上顎前方牽引を行った症例2016

    • Author(s)
      今野正裕、飯嶋雅弘、今野 萌、溝口到
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      徳島県、徳島市、アスティとくしま
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 顔面非対称を伴う不正咬合の統計学的分類2016

    • Author(s)
      今野正裕、飯嶋雅弘、今野 萌、溝口到
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      徳島県、徳島市、アスティとくしま
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 術後矯正を重視して動的治療期間を短縮した外科的矯正治療2016

    • Author(s)
      中尾友也、上地 潤、溝口 到
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      徳島県、徳島市、アスティとくしま
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 閉塞性睡眠時無呼吸症により治療方針の変更を行った顎変形症の1例2016

    • Author(s)
      松沢史宏,中尾友也,柴田孝典,溝口 到
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      徳島県、徳島市、アスティとくしま
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] コルチコトミーを併用してデンタルコンペンセーションを除去した骨格性Ⅲ級に対する外科的矯正治療2016

    • Author(s)
      笹本さえら、上地 潤、北所弘行、武田成浩、柴田考典、溝口 到
    • Organizer
      第75回日本矯正歯科学会大会
    • Place of Presentation
      徳島県、徳島市、アスティとくしま
    • Year and Date
      2016-11-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 伸展刺激下でのラット関節円板培養細胞のfibromodulinとlumicanの相互作用2016

    • Author(s)
      樫尾治奈、山口 優、中尾友也、鳥谷奈保子、溝口 到
    • Organizer
      第29回日本顎関節学会
    • Place of Presentation
      神奈川県、箱根町、箱根湯本富士屋ホテル
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] In vitro investigation of nanoproperties at dentin - Pulp capping material interface2016

    • Author(s)
      Alapati S, Iijima M, Brantley WA, Ito S, Muguruma T, Saito T, Mizoguchi I
    • Organizer
      94th Annual Meeting of the IADR
    • Place of Presentation
      韓国、ソウル市、COEX
    • Year and Date
      2016-06-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 顔面非対称症例における下顎頭の三次元形態分析2016

    • Author(s)
      宮田さえら、上地 潤、今野正裕、柴田考典、溝口 到
    • Organizer
      第25回日本顎変形症学会
    • Place of Presentation
      東京都、千代田区、一橋講堂
    • Year and Date
      2016-06-04
    • Related Report
      2016 Annual Research Report
  • [Presentation] 顎関節荷重負荷が成長期ラット関節円板のproteoglycan発現に及ぼす影響2015

    • Author(s)
      中尾友也,樫尾治奈、鳥谷奈保子、林 一夫、溝口 到
    • Organizer
      第28回日本顎関節学会、第20回日本口腔顔面疼痛学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2015-07-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] ラット関節円板細胞の伸展刺激に対するcollagen およびproteoglycanの発現への影響2015

    • Author(s)
      樫尾治奈、中尾友也,鳥谷奈保子、林 一夫、溝口 到
    • Organizer
      第28回日本顎関節学会、第20回日本口腔顔面疼痛学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2015-07-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 下顎骨の成長と下顎頭軟骨2014

    • Author(s)
      溝口 到
    • Organizer
      日本矯正歯科学会
    • Place of Presentation
      千葉市幕張メッセ
    • Year and Date
      2014-10-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヒト歯根膜線維芽細胞の機能維持におけるオステオポンチンとメカニカルストレスの役割2014

    • Author(s)
      荒川俊哉、岡山三紀、溝口 到、田隈泰信
    • Organizer
      日本歯科基礎医学会
    • Place of Presentation
      福岡市福岡国際会議場
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] SNAREタンパク質のTALENを用いた機能解析2014

    • Author(s)
      田隈泰信、荒川俊哉、岡山三紀、溝口 到
    • Organizer
      日本歯科基礎医学会
    • Place of Presentation
      福岡市福岡国際会議場
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 顎関節円板荷重負荷がラット関節円板のproteoglycansのmRNA発現に及ぼす影響2014

    • Author(s)
      中尾友也、樫尾治奈、鳥谷 奈保子、林 一夫、溝口 到
    • Organizer
      日本顎関節学
    • Place of Presentation
      福岡市九州大学医学部百年講堂
    • Year and Date
      2014-07-19 – 2014-07-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 顔面非対称と下顎頭形態の左右差との関連性に関する三次元形態分析2014

    • Author(s)
      宮田さえら、上地 潤、今野正裕、溝口
    • Organizer
      北海道矯正歯科学会
    • Place of Presentation
      札幌市北海道歯科医師会館
    • Year and Date
      2014-06-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] 合挙上による咬合改変が成長期ラット関節円板のversicanの発現に及ぼす影響2013

    • Author(s)
      中尾友也、鳥谷奈保子、林 一夫、溝口 到
    • Organizer
      第26回日本顎関節学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 咬合改変による機械的刺激でのラット関節円板のversican発現2013

    • Author(s)
      中尾友也、松沢史宏、永坂 萌、鳥谷奈保子、溝口 到
    • Organizer
      第72回日本矯正歯科学会
    • Place of Presentation
      松本
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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