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Study on the lymphatic edema and wound, honey and burn, estrogen and wound for the nursing care by using animal

Research Project

Project/Area Number 25293430
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Fundamental nursing
Research InstitutionKanazawa University

Principal Investigator

Nakatani Toshio  金沢大学, 保健学系, 教授 (60198124)

Co-Investigator(Kenkyū-buntansha) SUGAMA Junko  金沢大学, 保健学系, 教授 (00203307)
OKUWA Mayumi  金沢大学, 保健学系, 教授 (30303291)
NISHIZAWA Tomoe  新潟大学, 医歯学系, 准教授 (50579597)
DAI Misako  金沢大学, 保健学系, 助教 (50614864)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Keywords皮膚創傷 / 看護ケア / リンパ浮腫 / 蜂蜜 / 火傷 / エストロゲン / 常温プラズマ / 脂肪細胞 / 筋注 / 皮膚創傷治癒 / 低タンパク質 / リンパ管 / 熱傷 / 低栄養 / プラズマ
Outline of Final Research Achievements

A mouse model of lymphedema after inguinal lymphadenectomy with a skin would at the same site was created to examine the influences of the condition. Honey, and estrogen as a female hormone on would healing were examined. The following findings were obtained: the influence of lymphedema on the wound healing remained unclear, as lymphedema did not persist; the effect of honey on the third-degree burn was poor; estrogen positively affected wound healing in elderly and malnourished mice; and a plasma jet generated by applying a high voltage to argon gas was also suggested to promote would healing.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (40 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 10 results,  Acknowledgement Compliant: 9 results) Presentation (22 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Remarks (5 results)

  • [Journal Article] A simple technique to improve contractile effect of cold plasma jet on acute wound of mouse by dropping water.2015

    • Author(s)
      Nasruddin, Yukari Nakajima, Kanae Mukai, Emi Komatsu, Heni Setyowati Esti Rahayu, Muhammad Nur, Tatsuo Ishijima, Hiroshi Enomoto, Yoshihiko Uesugi, Junko Sugama, Toshio Nakatani
    • Journal Title

      Plasma Processes and Polymers

      Volume: - Issue: 10 Pages: 1128-1138

    • DOI

      10.1002/ppap.201400236

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of the effects of a combination of Japanese honey and hydrocolloid dressing on cutaneous wound healing in male mice2015

    • Author(s)
      Kanae Mukai, Miki Koike, Saki Nakamura, Fumika Katagiri, Saki Nojiri, Yuki Yamada, Eri Miyajima, Mayuko Matsumoto, Emi Komatsu, Yukari Nakajima, Tamae Urai, Naoko Murakado, Toshio Nakatani
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 2015 Pages: 1-9

    • DOI

      10.1155/2015/910605

    • NAID

      120005613975

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Anatomical investigation of position of crossing of superficial branch of radial nerve and cephalic vein and its frequency2015

    • Author(s)
      Kanae Mukai, Emi Komatsu, Tamae Urai, Yukari Nakajima, Kimi Asano, Noriyuki Ozaki, Toshio Nakatani
    • Journal Title

      Structure and Function(形態・機能)

      Volume: 14 Pages: 3-11

    • NAID

      130005100065

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 未経験者による三角筋筋肉内注射の位置決め器具の使用に関する正確性と簡便性の生体での検討2015

    • Author(s)
      向井 加奈恵,小松 恵美,中島 由加里,浦井 珠恵,浅野 きみ,中谷 壽男
    • Journal Title

      形態・機能

      Volume: 14 Pages: 75-83

    • NAID

      130005144368

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 17β-estradiol administration promotes delayed cutaneous wound healing in 40-week ovariectomized female mice.2015

    • Author(s)
      Kanae Mukai, Yukari Nakajima, Tamae Urai, Emi Komatsu, Nasruddin, Junko Sugama, Toshio Nakatani
    • Journal Title

      International Wound Journal

      Volume: - Issue: 5 Pages: 636-644

    • DOI

      10.1111/iwj.12336

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction2014

    • Author(s)
      Nasruddin, Y. Nakajima, K. Mukai, H. Setyowati Esti Rahayu, Muhammad Nur, T. Ishijima, H. Enomoto, Y. Uesugi, J. Sugama, T. Nakatani
    • Journal Title

      Clinical Plasma Medicine

      Volume: 2 Issue: 1 Pages: 1-5

    • DOI

      10.1016/j.cpme.2014.01.001

    • NAID

      120005411692

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of 17ß-estradiol administration on cutaneous wound healing in 24-week ovariectomized female mice.2014

    • Author(s)
      Kanae Mukai, Yukari Nakajima, Tamae Urai, Emi Komatsu, Kana Takata, Yuriko Miyasaka, Nasruddin, Junko Sugama, Toshio Nakatani
    • Journal Title

      Journal of Hormones

      Volume: 2014 Pages: 1-8

    • DOI

      10.1155/2014/234632

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison of the cutaneous wound healing of ovariectomized mouse at 12 weeks with that of SHAM and estrogen-administered mice2014

    • Author(s)
      Kanae Mukai, Yuriko Miyasaka, Kana Takata, Tamae Urai, Yukari Nakajima, Emi Komatsu, Junko Sugama, Toshio Nakatani,
    • Journal Title

      Journal of Hormones

      Volume: 2014 Pages: 1-6

    • DOI

      10.1155/2014/484258

    • NAID

      120005456205

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ご遺体での三角筋筋注部位の位置決め器具の有用性と決定した筋注部位の安全性の検討.2014

    • Author(s)
      小松 恵美,向井 加奈恵,中島 由加里,尾崎 紀之,中谷 壽男
    • Journal Title

      形態・機能

      Volume: 13 Pages: 17-24

    • NAID

      130005068662

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The effect of 17β-estradiol on cutaneous wound healing in protein-malnourished ovariectomized female mouse model2014

    • Author(s)
      Kanae Mukai, Emi Komatsu, Yukari Nakajima, Tamae Urai, Nasruddin, Junko Sugama, Toshio Nakatani
    • Journal Title

      PLoS ONE

      Volume: 9 Issue: 12 Pages: 1-20

    • DOI

      10.1371/journal.pone.0115564

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Is estrogen effective for full-thickness cutaneous wound healing in young male mice?2013

    • Author(s)
      Y. Nakajima, Y. Eno, M. Hirata, S. Kobori, A. Sugiura, M. Takeuchi, M Taniguchi, M. Tanisaki, A. Hayashi, K. HikishimaN. Matsuo, N. Wada, K. Mukai, N. Murakado, M. Okuwa, T. Nakatani
    • Journal Title

      Wounds

      Volume: 25 Pages: 278-286

    • NAID

      120005342818

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the effects of honey on acute-phase deep burn wounds2013

    • Author(s)
      Yukari Nakajima, Kanae Mukai, Nasruddin, Emi Komatsu, Terumi Iuchi, Yukie Kitayama, Junko Sugama, Toshio Nakatani
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 2013 Pages: 1-20

    • DOI

      10.1155/2013/784959

    • NAID

      120005347250

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of three types of Japanese honey on full-thickness wound in mice2012

    • Author(s)
      ukari Nakajima, Kanae Mukai, Yukie Kitayama, Naoko Murakado, Mayumi Okuwa,Toshio Nakatani
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 2013 Pages: 11-11

    • DOI

      10.1155/2013/504537

    • NAID

      120005253835

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Evaluation of the effect of estradiol benzoate on cutaneous wound healing in ovariectomized female mice –Focus on the inflammatory response-2016

    • Author(s)
      Kanae Mukai, Tamae Urai, Kimi Asano, Yukari Nakajima, Toshio Nakatani
    • Organizer
      WUWHS2016
    • Place of Presentation
      イタリア フィレンツェ
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of honeydew honey on wound healing2016

    • Author(s)
      Yukari Nakajima, Kanae Mukai, Tamae Urai, Kimi Asano, Megumi Ohta, Ikuko Kato, Azusa Kawaguchi, Yui Kinoshita, Yuri Kumagai, Ayaka Sakashita, Takuto Sawazaki,, Asuka Yamazaki, Toshio Nakatani
    • Organizer
      WUWHS2016
    • Place of Presentation
      イタリア フィレンツェ
    • Year and Date
      2016-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 鼡径リンパ節を郭清した下腿に作製した創傷は治癒が遅延するか2015

    • Author(s)
      中谷壽男,小松恵美,浅野きみ,向井加奈恵,浦井珠恵,中島由加里
    • Organizer
      第45回日本創傷治癒学会
    • Place of Presentation
      東京都千代田区 JRタワーホール&カンファレンス
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Estradiol Benzoateの創部塗布による皮膚創傷治癒への効果―肉眼的検討―2015

    • Author(s)
      向井加奈恵,浦井珠恵,浅野きみ,中島由加里,須釜淳子,中谷壽男
    • Organizer
      第45回日本創傷治癒学会
    • Place of Presentation
      東京都千代田区 JRタワーホール&カンファレンス
    • Year and Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 三角筋筋肉内注射位置決め器具の使用未経験者における測定部位のずれの検討2015

    • Author(s)
      浦井珠恵、向井加奈恵、小松恵美、中島由加里、浅野きみ、中谷壽男
    • Organizer
      コ・メディカル形態機能学会 第14回学術集会
    • Place of Presentation
      埼玉県入間郡埼玉医科大学川角キャンパス
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] リンパ節切除とリンパ管切断による皮膚創傷治癒への影響2015

    • Author(s)
      小松恵美,向井加奈恵,浦井珠恵,浅野きみ,中島由加里,中谷壽男
    • Organizer
      第17回日本褥瘡学会学術集会
    • Place of Presentation
      宮城県仙台市仙台国際センター
    • Year and Date
      2015-08-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Controlling the effect of cold plasma treatment on mouse skin wound by modifying its surface using water2015

    • Author(s)
      Nasruddin,Yukari Nakajima, Kanae Mukai, Emi Komatsu, Heni Setyowati Esti Rahayu, Muhammad Nur, Tatsuo Ishijima, Hiroshi Enomoto, Yoshihiko Uesugi, Junko Sugama, Toshio Nakatani
    • Organizer
      ISPLASMA 2015 (8th International Conference on Plasma-Nano technology and Science) i
    • Place of Presentation
      名古屋大学((愛知県名古屋市)
    • Year and Date
      2015-03-26 – 2015-03-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 看護学教育での解剖生理学の教育の方法 Teaching anatomy and physiology in nursing education2015

    • Author(s)
      中谷 壽男
    • Organizer
      Symposium 30 コメディカル解剖・生理学教育に必要と思われる教授内容と視点 第120回日本解剖学会・全国学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cutaneous tissue repair following atmospheric plasma jet treatment2015

    • Author(s)
      Nasruddin,Yukari Nakajima, Kanae Mukai, Emi Komatsu, Heni Setyowati Esti Rahayu, Muhammad Nur, Tatsuo Ishijima, Hiroshi Enomoto, Yoshihiko Uesugi, Junko Sugama, Toshio Nakatani
    • Organizer
      2nd International Workshop on Plasma for Cancer Therapy (IWPCT)
    • Place of Presentation
      名古屋大学東山キャンパス(愛知県名古屋市)
    • Year and Date
      2015-03-16 – 2015-03-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Influence of obesity on cutaneous wound healing in an obese mouse model fed a high-fat diet2015

    • Author(s)
      Tamae Urai, Kanae Mukai, Tatsuhiko Matsushita, Emi Komatsu, Yukari Nakajima, Junko Sugama, Toshio Nakatani
    • Organizer
      18th East Asian Forum Of Nursing Scholars(EAFONS)
    • Place of Presentation
      NTUH International Convention Center (Taiwan)
    • Year and Date
      2015-02-05 – 2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 3%蛋白質含有食飼料を摂取した卵巣切除マウスの皮膚創傷への17β-estradiol投与の効果2014

    • Author(s)
      向井加奈恵、小松恵美、中島由加里、浦井珠恵、須釜淳子、中谷壽男
    • Organizer
      第44回日本創傷治癒学会
    • Place of Presentation
      ホテルメトロポリタン仙台(宮城県仙台市)
    • Year and Date
      2014-12-02 – 2014-12-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 三角筋筋肉注射の際に腋窩神経の走行を推測する方法の正確性と簡便性の検討2014

    • Author(s)
      小松恵美,向井加奈恵,中島由加里,浦井珠恵,中谷壽男
    • Organizer
      第13回日本看護技術学会学術集会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2014-11-22 – 2014-11-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 橈骨神経浅枝が皮下へ出現する位置及び橈骨神経浅枝と橈側皮静脈の交叉の位置と頻度に関する解剖学的調査2014

    • Author(s)
      向井加奈恵、小松恵美、浦井珠恵、中島由加里、尾崎紀之、中谷壽男
    • Organizer
      日本解剖学会第74回中部支部学術集会
    • Place of Presentation
      金沢大学宝町キャンパス(石川県金沢市)
    • Year and Date
      2014-10-11 – 2014-10-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] ご遺体を用いた橈側皮静脈と橈骨神経浅枝の交叉の位置と頻度の調査2014

    • Author(s)
      向井加奈恵、小松恵美、浦井珠恵、中島由加里、尾崎紀之、中谷壽男
    • Organizer
      第13回コ・メディカル形態機能学会
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Year and Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 創傷治癒過程の炎症期においてマウスの皮膚全層欠損創へ日本産蜂蜜を使用することによる効果の検討2014

    • Author(s)
      小松恵美,中島由加里,向井加奈恵,大桑麻由美,中谷壽男
    • Organizer
      第16回日本褥瘡学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウスの皮膚全層欠損創への日本産蜂蜜とハイドロコロイド被覆材併用による効果の検証2014

    • Author(s)
      向井加奈恵,小松恵美,中島由加里,中谷壽男
    • Organizer
      第16回日本褥瘡学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Improving the Healing Effect of Cold Plasma Treatmenton Wound using Water Adding2014

    • Author(s)
      Nasruddin, Emi Komatsu, Kanae Mukai, Yukari Nakajima, Heni SetyowatiEsti Rahayu, Muhammad Nur, Tatsuo Ishijima, Hiroshi Enomoto, Yoshihiko Uesugi, Junko Sugama, Toshio Nakatani
    • Organizer
      8th International Conference on Reactive Plasmas/ 31st Symposium on Plasma Processing
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 17β-estradiol promotes cutaneous wound healing in 24-week ovariectomized female mice by modulating wound inflammation and promoting wound contraction2013

    • Author(s)
      Kanae Mukai, Yukari Nakajima, Emi Komatsu, Junko Sugama, Toshio Nakatani
    • Organizer
      XXIII International Symposium on Morphological Sciences
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター(新潟県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Study of the effects of combining Japanese honey and a hydrocolloid dressing on skin wound healing2013

    • Author(s)
      Emi Komatsu, M Hattori, M Yamanishi, M Hutakuchi, K Kanzaka, Y Uno, S Yamazaki, S Kato, T Yamamoto, Y Nakajima, K Mukai, N Murakado, M Ookuwa, T Nakatani
    • Organizer
      XXIII International Symposium on Morphological Sciences
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター(新潟県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 急性期三度熱傷創における蜂蜜の抗炎症作用の効果2013

    • Author(s)
      中島由加里,向井加奈恵、小松恵美,北山幸枝,須釜淳子,中谷壽男
    • Organizer
      第43回日本創傷治癒学会
    • Place of Presentation
      別府湾ロイヤルホテル(大分県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 蛋白質栄養不良卵巣切除マウス皮膚創傷への 17β エストラジオール経皮投与の効果―肉眼 的所見による検証-2013

    • Author(s)
      向井 加奈恵,小松 恵美,中島 由加里,須釜 淳子,中谷 壽男
    • Organizer
      第43回日本創傷治癒学会
    • Place of Presentation
      別府湾ロイヤルホテル(大分県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 皮膚創傷治癒過程に日本産蜂蜜とハイドロコロイド被覆材を併用することによる効果の検討2013

    • Author(s)
      小松恵美,宇野由花、加藤静香,服部真弓,二口美佐子,山崎静,山西未紗,勘坂佳世,山本友美,中島由加里,向井加奈恵,村角直子,大桑麻由美,中谷壽男
    • Organizer
      第43回日本創傷治癒学会
    • Place of Presentation
      別府湾ロイヤルホテル(大分県)
    • Related Report
      2013 Annual Research Report
  • [Remarks] 金沢大学医薬保健研究域保健学系・金沢大学医薬保健総合研究域保健学専攻 創傷看護技術学分野

    • URL

      http://wmn.w3.kanazawa-u.ac.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://mhs3.mp.kanazawa-u.ac.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks]

    • URL

      http://wmn.w3.kanazawa-u.ac.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks] 金沢大学 看護科学領域 創傷看護技術学グループ

    • URL

      http://square.umin.ac.jp/sugama/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 金沢大学学術情報リポジトリKURA

    • URL

      http://dspace.lib.kanazawa-u.ac.jp/dspace/

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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