Distribution of antimicrobial brominated biphenols produced by marine biota in southeast Asia
| Project/Area Number |
25303011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Green/Environmental chemistry
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| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小瀧 裕一 北里大学, 水産学部, 准教授 (30113278)
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| Co-Investigator(Renkei-kenkyūsha) |
ENDO Tetsuya 北海道医療大学, 薬学部, 准教授 (10133216)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Keywords | 海藻 / 臭素化合物 / 起源 / 代謝 / 海洋生物 / 環境分析 / 抗菌性化学物質 / 東南アジア |
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| Outline of Final Research Achievements |
The origin of naturally produced brominated biphenyls (OH-BDE) was found in brown algae (Sargassum sp.) and bivalve (Spondylus sp.) in Southeast Asia (Philippines, Indonesia). Genetic analysis indicated the marine bacteria (Pseudoanteromonus sp) in the algae could produce OH-BDE, which are further methylated to methoxy metabolites (MeO-BDE) and accumulate in higher trophic organisms. Secondary metabolites (hydroxylated dioxins) during this process were found and partly distributed in fish. Human exposure to MeO-BDE may be readily metabolized in liver to OH-BDE by CYP2B6, which are retained in blood.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Levels, profiles and dietary sources of hydroxylated PCBs and hydroxylated and methoxylated PBDEs in Japanese women serum samples.2016
Author(s)
Haraguchi, K., Ito, Y., Takagi, M., Fujii, Y., Harada, K.H., Koizumi, A.
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Journal Title
Environment International
Volume: 97
Pages: 155-162
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of quercetin on the uptake and efflux of aristolochic acid I from Caco-2 cell monolayers2016
Author(s)
Kimura, O., Fujii, Y., Haraguchi, K., Ohta, C., Koga, N., Kato, Y., Endo, T.
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Journal Title
Journal of Ｐharmacy and Ｐharmacology
Volume: 68
Pages: 883-889
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Distribution and excretion of 2,2′,3,4′,5,5′,6-heptachlorobiphenyl (CB187) and its metabolites in rats and guinea pigs.2015
Author(s)
Ohta, C.; Haraguchi, K.; Kato, Y.; Endo, T.; Kimura, O.; Koga, N.
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Journal Title
Chemosphere
Volume: 118
Pages: 5-11
Related Report
Peer Reviewed
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[Journal Article] Dietary exposure to phenolic and methoxylated organohalogen contaminants in relation to their concentration in breast milk and serum in Japan.2014
Author(s)
Fujii, Y., Nishimura. E, Kato, Y., Harada, K.H., Koizumi, A., Haraguchi, K.
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Journal Title
Environment International
Volume: 63
Pages: 19-25
Related Report
Peer Reviewed
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[Presentation] Metabolism of 2，2‘，3，4，4’，5，6‘-heptachlorobiphenyl （CB182） by rat, guinea pig and human liver microsomes,2016
Author(s)
Ohta C, Fujii Y, Haraguchi K, Kato Y, Kimura O, Endo T, Koga N,
Organizer
36th International symposium on halogenated persistent organic pollutants
Place of Presentation
Firenze, Italy
Year and Date
2016-08-28
Related Report
Int'l Joint Research
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[Presentation] A major source of dietary exposure to long-chain perfluorinated carboxylic acids2015
Author(s)
Fujii, Yukiko; Sakurada, Tsukasa; Kuga, Ayuka; Kinoshita, Marika; Harada, Kouji; Koizumi, Akio; Kimura, Osamu; Endo, Tetsuya; Haraguchi, Koichi
Organizer
Society of Toxicology 54th Annual Meeting
Place of Presentation
San Diego, California
Year and Date
2015-03-22 – 2015-03-26
Related Report
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