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Development of diagnostic methods for viral zoonoses derived from wild animals and birds and the comparative epidemiological study of the viral zoonones

Research Project

Project/Area Number 25304040
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Veterinary medical science
Research InstitutionHokkaido University

Principal Investigator

KARIWA Hiroaki  北海道大学, (連合)獣医学研究科, 教授 (70224714)

Co-Investigator(Kenkyū-buntansha) 有川 二郎  北海道大学, 医学(系)研究科(研究院), 教授 (10142704)
好井 健太朗  北海道大学, (連合)獣医学研究科, 准教授 (50421988)
森松 組子 (吉松組子 / 吉松 組子 / 森松 組子(吉松組子))  北海道大学, 医学(系)研究科(研究院), 准教授 (90220722)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords人獣共通感染症 / ウイルス / ハンタウイルス感染症 / ダニ媒介性脳炎 / ウエストナイル熱 / 診断法 / 疫学 / ハンタウイルス / 腎症候性出血熱 / 獣医学 / 感染症 / モンゴル / 国際研究者交流
Outline of Final Research Achievements

In this study, simple diagnostic methods were developed for zoonoses, such as hantavirus infections, tick-borne encephalitis, and West Nile fever, which are severe and fatal diseases, and are considered as major problems in many countries. ELISA and immunochromatography were developed to detect anti-hantavirus antibodies in various rodents. ELISA systems using viral-like particles (SPs) of tick-borne encephalitis virus conjunctive with IgG and Strep-tag were established. A stable reverse genetics system for West Nile virus was developed by using homologous recombination.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (91 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (2 results) Journal Article (18 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 17 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (71 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] モンゴル国立農業大学(モンゴル)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Hepatologi(ロシア連邦)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A novel reverse genetics system for production of infectious West Nile virus using homologous recombination in mammalian cells. J Virol Methods2016

    • Author(s)
      Kobayashi S, Yoshii K, Hirano M, Muto M, Kariwa H.
    • Journal Title

      J Virol Methods.

      Volume: 240 Pages: 14-20

    • DOI

      10.1016/j.jviromet.2016.11.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a serodiagnostic multi-species ELISA against tick-borne encephalitis virus using subviral particles.2016

    • Author(s)
      Inagaki E, Sakai M, Hirano M, Muto M, Kobayashi S, Kariwa H, Yoshii K
    • Journal Title

      Ticks Tick Borne Dis

      Volume: S1877-959X Issue: 5 Pages: 30039-30045

    • DOI

      10.1016/j.ttbdis.2016.03.002

    • NAID

      120006318731

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Rab8b regulates transport of West Nile virus particles from recycling endosomes2016

    • Author(s)
      Kobayashi S, Suzuki T, Kawaguchi A, Phongphaew W, Yoshii K, Iwano T, Harada A, Kariwa H, Orba Y, Sawa H
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 291 Issue: 12 Pages: 6559-6568

    • DOI

      10.1074/jbc.m115.712760

    • NAID

      120005906784

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Isolation and characterization of tick-borne encephalitis virus from Ixodes persulcatus in Mongolia in 2012.2015

    • Author(s)
      Muto M, Bazartseren B, Tsevel B, Dashzevge E, Yoshii K, Kariwa H
    • Journal Title

      Ticks and tick-borne diseases.

      Volume: 6 Issue: 5 Pages: 623-629

    • DOI

      10.1016/j.ttbdis.2015.05.006

    • NAID

      120005768779

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Virulence of tick-borne encephalitis virus is associated with intact conformational viral RNA structures in the variable region of the 3'-UTR2015

    • Author(s)
      Sakai, M., Muto, M., Hirano, M., Kariwa, H., Yoshii, K.
    • Journal Title

      Virus Res

      Volume: 203 Pages: 36-40

    • DOI

      10.1016/j.virusres.2015.03.006

    • NAID

      120005752848

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of the Thogoto virus from a Haemaphysalis longicornis in Kyoto city, Japan.2015

    • Author(s)
      Yoshii K, Okamoto N, Nakao R, Hofstetter RK, Yabu T, Masumoto H, Someya A, Kariwa H, Maeda A
    • Journal Title

      J Gen Virol

      Volume: 96 Issue: 8 Pages: 2099-2103

    • DOI

      10.1099/vir.0.000177

    • NAID

      120005820712

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The pathogenesis of 3 neurotropic flaviviruses in a mouse model depends on the route of neuroinvasion after viremia2015

    • Author(s)
      Nagata, N., Iwata-Yoshikawa, N., Hayasaka, D., Sato, Y., Kojima, A., Kariwa, H., Takashima, I., Takasaki, T., Kurane, I., Sata, T., Hasegawa, H.
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 74 Issue: 3 Pages: 250-260

    • DOI

      10.1097/nen.0000000000000166

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Critical Determinant of Neurological Disease Associated with Highly Pathogenic Tick-borne Flavivirus in Mice2014

    • Author(s)
      Yoshii K, Sunden Y, Yokozawa K, Igarashi M, Kariwa H, Holbrook MR, Takashima I.
    • Journal Title

      Journal of Virology

      Volume: 88 Issue: 10 Pages: 5406-5420

    • DOI

      10.1128/jvi.00421-14

    • NAID

      120005496501

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a tick-borne encephalitis serodiagnostic ELISA using recombinant Fc-antigen fusion proteins.2014

    • Author(s)
      Chidumayo NN, Yoshii K, Saasa N, Sakai M, Kariwa H
    • Journal Title

      Diagnostic microbiology and infectious disease

      Volume: 78 Issue: 4 Pages: 373-378

    • DOI

      10.1016/j.diagmicrobio.2013.12.014

    • NAID

      120005906756

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tick-borne flaviviruses alter membrane structure and replicate in dendrites of primary mouse neuronal cultures.2014

    • Author(s)
      Minato Hirano, Kentaro Yoshii, Mizuki Sakai, Rie Hasebe, Osamu Ichii and Hiroaki Kariwa
    • Journal Title

      JOURNAL OF GENERAL VIROLOGY

      Volume: 95 Issue: 4 Pages: 849-861

    • DOI

      10.1099/vir.0.061432-0

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variable region of the 3'UTR is a critical virulence factor in the Far-Eastern subtype of tick-borne encephalitis virus in a mouse model.2014

    • Author(s)
      Mizuki Sakai, Kentaro Yoshii, Yuji Sunden, Kana Yokozawa, Minato Hirano and Hiroaki Kariwa
    • Journal Title

      JOURNAL OF GENERAL VIROLOGY

      Volume: 95 Issue: 4 Pages: 823-835

    • DOI

      10.1099/vir.0.060046-0

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the European tick-borne encephalitis vaccine against Omsk hemorrhagic fever virus.2014

    • Author(s)
      Chidumayo NN, Yoshii K, Kariwa H
    • Journal Title

      Microbiol Immunol

      Volume: 58 Issue: 2 Pages: 112-118

    • DOI

      10.1111/1348-0421.12122

    • NAID

      40020007920

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ncreased Pathogenicity of West Nile Virus (WNV) by Glycosylation of Envelope Protein and Seroprevalence of WNV in Wild Birds in Far Eastern Russia.2014

    • Author(s)
      Kariwa H, Murata R, Totani M, Yoshii K, Takashima I
    • Journal Title

      International journal of environmental research and public health

      Volume: 10 Issue: 12 Pages: 7144-7164

    • DOI

      10.3390/ijerph10127144

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-1 inked glycan in tick-borne encephalitis virus envelope protein affects viral secretion in mammalian cells, but not in tick cells.2013

    • Author(s)
      Kentaro Yoshii, Natsumi Yanagihara, Mariko Ishizuka, Mizuki Sakai, Hiroaki Kariwa
    • Journal Title

      JOURNAL OF GENERAL VIROLOGY

      Volume: 94 Issue: 10 Pages: 2249-2258

    • DOI

      10.1099/vir.0.055269-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic and biological characterization of tick-borne encephalitis virus isolated from wild rodents in southern Hokkaido, Japan in 2008.2013

    • Author(s)
      Yoshii Kentaro, Shoko Yamazaki, Keita Mottate, Noriyo Nagata, Takahiro Seto, Takashiro Sanada, Mizuki Sakai, Hiroaki Kariwa, Ikuo Takashima
    • Journal Title

      Vector-Borne and Zoonotic Diseases

      Volume: 13 Issue: 6 Pages: 406-414

    • DOI

      10.1089/vbz.2012.1231

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ecological and genetic analyses of the complete genomes of Culex flavivirus strains isolated from Culex tritaeniorhynchus and Culex pipiens (Diptera: Culicidae) group mosquitoes2013

    • Author(s)
      Obara-Nagoya M, Yamauchi T, Watanabe M, Hasegawa S, Iwai-Itamochi M, Horimoto E, Takizawa T, Takashima I, Kariwa H
    • Journal Title

      Journal of Medical Entomology

      Volume: 50 Pages: 300-309

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus2013

    • Author(s)
      Kentaro Yoshii, Kanako Moritoh, Noriyo Nagata, Kana Yokozawa, Mizuki Sakai, Nobuya Sasaki, Hiroaki Kariwa, Takashi Agui, Ikuo Takashima
    • Journal Title

      Archives of Virology

      Volume: 158 Issue: 5 Pages: 1039-1046

    • DOI

      10.1007/s00705-012-1579-1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本のげっ歯類におけるハンタウイルス感染の血清疫学調査とエゾヤチネズミが保有するHokkaidoウイルスの分離2013

    • Author(s)
      苅和宏明, 尾崎由佳, 真田崇宏, 池中良徳, 石塚真由美, 坪田敏夫, 好井健太朗, 吉松組子, 有川二郎, 高島郁夫
    • Journal Title

      獣医畜産新報

      Volume: 66 Pages: 262-264

    • Related Report
      2013 Annual Research Report
  • [Presentation] Analysis of the transport mechanism of the genomic RNA of flavivirus in neurites2016

    • Author(s)
      Minato Hirano, Mizuki Sakai, Memi Muto, Shintaro Kobayashi, Hiroaki Kariwa, Kentaro Yoshii
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Analysis of genome replication and packaging of tick-borne encephalitis virus using trans-complementation2016

    • Author(s)
      Sayaka Yamauchi, Shintaro Kobayashi, Minato Hirano, Memi Muto, Mariko Ishizuka, Hiroaki Kariwa, Kentaro Yoshii
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Identification of host proteins interacting with the 3’-UTR of tick-borne encephalitis virus2016

    • Author(s)
      Memi Muto, Wataru Kamitani, Minato Hirano, Shintaro Kobayashi, Hiroaki Kariwa, Kentaro Yoshii
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Research on the complementation of genome replication of Hokkaido virus by co-infection with other hantaviruses2016

    • Author(s)
      Sayo Kajikawa, Rina Iwasaki, Takahiro Sanada, Shintaro Kobayashi, Kentaro Yoshii, Hiroaki Kariwa
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Capsid protein of West Nile virus is responsible for accumulation of ubiquitinated denatured protein2016

    • Author(s)
      Shintaro Kobayashi, Kentaro Yoshii, Wallaya Phongphaew, Minato Hirano, Memi Muto, Yasuko Orba, Hirofumi Sawa, Hiroaki Kariwa
    • Organizer
      The 64th Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Annual Research Report
  • [Presentation] Hokkaidoウイルスと他のハンタウイルスの共感染の補完に関する研究2016

    • Author(s)
      梶河紗代、岩崎里奈、真田崇弘、小林進太郎、好井健太朗、苅和宏明
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] フラビウイルスゲノムの神経細胞内輸送機構の解析2016

    • Author(s)
      平野港、酒井瑞紀、武藤芽未、小林進太郎、苅和宏明、好井健太朗
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] In trans補完系によるダニ媒介性脳炎ウイルスのゲノム複製機構の解析2016

    • Author(s)
      山内沙也果、小林進太郎、平野港、武藤芽未、石塚万里子、苅和宏明、好井健太朗
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ダニ媒介性脳炎ウイルスのNucleoside inhibitor耐性変異の解析2016

    • Author(s)
      近藤寛史、平野港、石塚万里子、武藤芽未、小林進太郎、苅和宏明、Ruzek Daniel、好井健太朗
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ウエストナイルウイルスの粒子放出過程におけるRab8b蛋白質の役割2016

    • Author(s)
      小林進太郎、鈴木忠樹、川口晶、Wallaya Phongphaew、好井健太朗、苅和宏明、大場靖子、澤洋文
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ダニ媒介性脳炎ウイルスの神経細胞内におけるウイルスゲノムRNA輸送機構の解析2015

    • Author(s)
      平野港、境瑞紀、苅和宏明、小林進太郎、好井健太朗.
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] ウエストナイルウイルス感染による変性タンパク質蓄積機構の解析.2015

    • Author(s)
      小林進太郎、Wallaya Phongphaew、好井健太朗、平野港、武藤芽未、大場靖子、澤洋文、苅和宏明.
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] BAP31 regulates the assembly and secretory pathway of the flavivirus particles.2015

    • Author(s)
      Kentaro Yoshii,Mariko Ishizuka,Shintaro Kobayashi,Wataru Kamitani,Hiroaki Kariwa
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Survival dynamics of tick-borne encephalitis virus surrogate Langat virus in Haemaphysalis longicornis.2015

    • Author(s)
      Talactac Melbourne Rio,Kentaro Yoshii,Tetsuya Tanaka,Kozo Fujisaki,Masami Mochizuki
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Analysis of the transport mechanism of the genomic RNA of TBEV in the neurites of neuron.2015

    • Author(s)
      Minato Hirano, Mizuki Sakai, Hiroaki Kariwa, Shintaro Kobayashi, Kentaro Yoshii.
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tick-borne flavivirus infection in main island of Japan.2015

    • Author(s)
      Hiroshi Shimoda,Kenzo Yonemitsu,Ryusei Kuwata,Daisuke Hayasaka,Kentaro Yoshii, Ken Maeda.
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Analysis of the accumulation mechanism of denatured proteins by West Nile virus infection.2015

    • Author(s)
      Shintaro Kobayashi,Phongphaew Wallaya,Kentaro Yoshii,Minato Hirano,Memi Muto, Yasuko Orba,Hirofumi Sawa,Hiroaki Kariwa.
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ダニ媒介性脳炎ウイルスの粒子形成・分泌に関与する宿主因子の同定と機能解析2015

    • Author(s)
      山内沙也果, 平野港, 石塚万里子, 武藤芽未, 小林進太郎, 神谷亘, 苅和宏明, 好井健太朗
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Isolation of Puumala virus using MRK 101 cell line which derived from the kidney of the grey red-backed vole (Myodes rufocanus bedfordiae)2015

    • Author(s)
      Daichi Kanameda,Takahiro Sanada,Mizuki Sakai,Masahiro Maki,Kumiko Yoshimatsu,Jiro Arikawa,Shintaro Kobayashi,Kentaro Yoshii,Hiroaki Kariwa.
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ダニ媒介性脳炎ウイルスのウイルス様粒子を用いた動物種非特異的な新規血清学的診断法の開発2015

    • Author(s)
      Eri Inagaki,Mizuki Sakai,Minato Hirano,Memi Muto,Shintaro Kobayashi,Hiroaki Kariwa, Kentaro Yoshii.
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ダニ媒介性脳炎ウイルスの神経細胞内におけるウイルスゲノムRNA輸送機構の解析.2015

    • Author(s)
      平野港、境瑞紀、小林進太郎、苅和宏明、好井健太朗.
    • Organizer
      第22回トガ・フラビ・ペスチウイルス研究会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] ダニ媒介性脳炎ウイルス様ウイルスの西日本のイノシシでの感染2015

    • Author(s)
      下田宙、水野純子、米満研三、南昌平、鍬田龍星、好井健太朗、早坂大輔、前田健.
    • Organizer
      第22回トガ・フラビ・ペスチウイルス研究会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] トゴトウイルスのゲノムRNAの解析とウイルス蛋白質発現の解析2015

    • Author(s)
      脊戸優、佐々木創平、岡本奈津実、好井健太朗、中尾亮、染谷梓、前田秋彦
    • Organizer
      第22回トガ・フラビ・ペスチウイルス研究会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] The variable region of the 3' untranslated region is a critical virulence factor in the Far-Eastern subtype of tick-borne encephalitis virus in mouse model.2015

    • Author(s)
      Mizuki Sakai, Minato Hirano, Memi Muto, Hiroaki Kariwa, Kentaro Yoshii.
    • Organizer
      International Symposium on Flaviviruses: Structure and Immunity.
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ダニ媒介性脳炎ウイルスのウイルス様粒子を用いた動物種非特異的な新規血清学的診断法の開発.2015

    • Author(s)
      稲垣恵理、境瑞紀、平野港、武藤芽未、苅和宏明、好井健太朗
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学(十和田市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] ムノクロマトグラフィー法によるハンタウイルスの迅速診断法の開発.2015

    • Author(s)
      小山芽以、吉松組子、好井健太朗、有川二郎、苅和宏明.
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学(十和田市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Virucidal activity of Haemaphysalis longicornis longicin P4 peptide against tick-borne encephalitis virus surrogate Langat virus.2015

    • Author(s)
      Melbourne Rio Talactac、好井健太朗、辻尚利、藤崎幸蔵、田仲哲也、望月雅美.
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学(十和田市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Tick-borne flavivirus infection in Japan.2015

    • Author(s)
      Hiroshi Shimoda, Kenzo Yonemitsu, Ryusei Kuwata, Kentaro Yoshii, Daisuke Hayasaka, Ken Maeda.
    • Organizer
      The International Conference on Diseases in Nature Communicable to Man
    • Place of Presentation
      Hamilton, Montana, USA,
    • Year and Date
      2015-08-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ダニ媒介性脳炎ウイルスの神経細胞内におけるウイルスゲノムRNA輸送機構の解析.2015

    • Author(s)
      平野港、境瑞紀、苅和宏明、好井健太朗.
    • Organizer
      第17回日本RNA学会年会
    • Place of Presentation
      ホテルライフォート札幌(札幌市)
    • Year and Date
      2015-07-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] フラビウイルス粒子形成・分泌に関与する宿主因子の検索及び機能解析2015

    • Author(s)
      好井健太朗、石塚万里子、神谷亘、苅和宏明.
    • Organizer
      第50回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      ホテル京都エミナース(京都市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経細胞内におけるダニ媒介性脳炎ウイルスのゲノムRNA輸送機構の解析2015

    • Author(s)
      平野港、境瑞紀、苅和宏明、好井健太朗.
    • Organizer
      第50回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      ホテル京都エミナース(京都市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] モンゴルにおけるダニ媒介性脳炎ウイルスの分離と性状解析2015

    • Author(s)
      武藤芽未、Boldbaatar Bazartseren、Bazartseren Tsevel、Erdenechimeg Dashzevge、好井健太朗、苅和宏明.
    • Organizer
      第50回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 山口県のイノシシからLangatウイルスに対する抗体の検出2015

    • Author(s)
      下田宙、早坂大輔、好井健太郎、米満研三、鍬田龍星、高野愛、前田健
    • Organizer
      第50回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      ホテル京都エミナース(京都市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] マダニからのThogoto virusの分離と解析2015

    • Author(s)
      佐々木創平、好井健太朗、岡本奈津実、中尾亮、染谷梓、前田秋彦.
    • Organizer
      第50回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      ホテル京都エミナース(京都市)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characterization of Hokkaido virus, Genus Hantavirus and generation of the Reassortant Virus with Puumala Virus2015

    • Author(s)
      Kariwa H, Sanada T, Iwasaki R, Yoshimatsu K, Arikawa J, Yoshii K, Takashima I.
    • Organizer
      17th International Conference on Emerging Infectious Diseases
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-01-27 – 2015-01-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tick-borne encephalitis virus alters membrane structure and replicates in dendrites of primary mouse neuronal cultures.2015

    • Author(s)
      Hirano M, Yoshii K, Hasebe R, Ichii O, Kariwa H.
    • Organizer
      17th International Conference on Emerging Infectious Diseases
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-01-27 – 2015-01-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] モンゴルにおけるダニ媒介性脳炎ウイルスの分離と性状解析2014

    • Author(s)
      武藤芽未, Boldbaatar, B., 好井健太朗, 苅和宏明.
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      神奈川県横浜市、パシフィコ横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Thogoto virus 様ウイルスのダニからの分離2014

    • Author(s)
      岡本奈津実, 好井健太朗, 中尾亮, Hofstetter, R. K., 藪智子, 益本大輝, 染谷梓, 前田秋彦
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      神奈川県横浜市、パシフィコ横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 極東型ダニ媒介性脳炎ウイルスの高病原化に関わる3'非翻訳領域variable regionの役割2014

    • Author(s)
      境瑞紀, 好井健太朗, 横澤香菜, 平野港, 苅和宏明
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      神奈川県横浜市、パシフィコ横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] HokkaidoウイルスとPuumalaウイルスの遺伝子再集合体の作出とその性状解析2014

    • Author(s)
      岩崎里菜, 真田崇弘, 好井健太朗, 苅和宏明
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      神奈川県横浜市、パシフィコ横浜
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] フラビウイルス粒子形成・分泌に関与する宿主因子の検索および機能解析2014

    • Author(s)
      好井健太朗
    • Organizer
      第21回トガ・フラビ・ペスチウイルス研究会
    • Place of Presentation
      神奈川県横浜市、パシフィコ横浜
    • Year and Date
      2014-11-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tick-borne flaviviruses alter membrane structure and replicate in dendrites of primary mouse neuronal cultures2014

    • Author(s)
      Hirano, M., Yoshii, K., Sakai, M., Hasebe, R., Ichii, O., Kariwa, H.
    • Organizer
      The 2nd Sapporo Summer Seminar for One Health
    • Place of Presentation
      Sapporo, Hokkaido, Hokkaido University
    • Year and Date
      2014-09-24 – 2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Isolation and characterization of tick-borne encephalitis virus from Mongolia2014

    • Author(s)
      Muto, M., Bazartseren, B., Yoshii, K., Kariwa, H.
    • Organizer
      The 2nd Sapporo Summer Seminar for One Health
    • Place of Presentation
      Sapporo, Hokkaido, Hokkaido University
    • Year and Date
      2014-09-24 – 2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] レポーター遺伝子発現ダニ媒介性脳炎ウイルスの作製と性状解析2014

    • Author(s)
      池端真帆, 好井健太朗, 境瑞紀, 平野港, 苅和宏明
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      神奈川県横浜市、パシフィコ横浜
    • Year and Date
      2014-09-10 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 極東型ダニ媒介性脳炎ウイルスの高病原化に関わる3'非翻訳領域variable regionの役割2014

    • Author(s)
      境瑞紀, 好井健太朗, 横澤香菜, 平野港, 苅和宏明.
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道札幌市、北海道大学
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] モンゴルにおけるダニ媒介性脳炎ウイルスの分離と性状解析2014

    • Author(s)
      武藤芽未, Boldbaatar, B., 好井健太朗, 苅和宏明.
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道札幌市、北海道大学
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 国内の野生動物およびダニから新規フラビウイルスの検出2014

    • Author(s)
      下田宙, 米満研三, 早坂大輔, 好井健太朗, 寺田豊, 野口慧多, 鍬田龍星, 高野愛, 前田健.
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道札幌市、北海道大学
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] HokkaidoウイルスとPuumalaウイルスの遺伝子再集合体の作出とその性状解析2014

    • Author(s)
      岩崎里菜, 真田崇弘, 好井健太朗, 苅和宏明
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道札幌市、北海道大学
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 北海道産マダニからの新規フレボウイルスの検出2014

    • Author(s)
      中尾亮, 梶原将大, 邱永晋, 森亜紀奈, 直亨則, 村松美笑子, 好井健太朗, 苅和宏明, 澤洋文, 杉本千尋, 高田礼人
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道札幌市、北海道大学
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] レポーター遺伝子発現ダニ媒介性脳炎ウイルスの作製と性状解析2014

    • Author(s)
      池端真帆, 好井健太朗, 境瑞紀, 平野港, 苅和宏明
    • Organizer
      第157回日本獣医学会学術集会
    • Place of Presentation
      北海道札幌市、北海道大学
    • Year and Date
      2014-09-09 – 2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Detection and isolation of novel phleboviruses from ticks in Japan2014

    • Author(s)
      Nakao, R., Kajihara, M., Matsuno, K., Qiu, Y., Mori, A., Nao, N., Yoshii, K., Kariwa, H., Sawa, H., Sugimoto, C., Takada, A., Ebihara, H
    • Organizer
      The 12th Biennial Conference of the Society for Tropical Veterinary Medicine and the VIII International Conference on Ticks and Tick-borne Pathogens
    • Place of Presentation
      Cape Town, South Africa.
    • Year and Date
      2014-08-24 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] A critical determinant of neurological disease associated with highly pathogenic tick-borne flavivirus in mice2014

    • Author(s)
      Yoshii, K., Sunden, Y., Yokozawa, K., Igarashi, M., Kariwa, H., Holbrook, M. R., Takashima, I.
    • Organizer
      International Union of Microbiological Societies 2014
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2014-07-27 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Tick-borne flaviviruses alter membrane structure and replicate in dendrites of primary mouse neuronal cultures2014

    • Author(s)
      Hirano, M., Yoshii, K., Sakai, M., Hasebe, R., Ichii, O., Kariwa, H.
    • Organizer
      International Union of Microbiological Societies 2014
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2014-07-27 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Variable region of the 3' UTR is a critical virulence factor in the Far-Eastern subtype of tick-borne encephalitis virus in a mouse model2014

    • Author(s)
      Sakai, M., Yoshii, K., Sunden, Y., Yokozawa, K., Hirano, M., Kariwa, H.
    • Organizer
      International Union of Microbiological Societies 2014
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2014-07-27 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Passage of Hantaan virus strain AA57 in Vero E6 cells affects pathogenicity in mice2014

    • Author(s)
      Kariwa, H., Maki, M., Seto, T., Sanada, T., Yoshimatsu, K., Arikawa, J., Yoshii, K.
    • Organizer
      International Union of Microbiological Societies 2014
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2014-07-27 – 2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] エゾヤチネズミ腎由来細胞におけるハンタウイルス感染に対するI型インターフェロン応答の解析2014

    • Author(s)
      中尾桃子, 真田崇弘, 好井健太朗, 佐々木宣哉, 亀山武志, 高岡晃教, 苅和宏明
    • Organizer
      第79回日本インターフェロン・ サイトカイン学会学術集会
    • Place of Presentation
      北海道札幌市、北海道大学
    • Year and Date
      2014-06-19 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] ダニ媒介性フラビウイルスのインターフェロンアンタゴニスト作用の解析2014

    • Author(s)
      好井健太朗, 鶴田征太郎, 境瑞紀, 苅和宏明.
    • Organizer
      第49回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      山口県山口市、ホテルニュータナカ
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 山口県の野生動物およびダニからフラビウイルスの検出2014

    • Author(s)
      下田宙, 米満研三, 早坂大輔, 好井健太朗, 寺田豊, 野口慧多, 鍬田龍星, 高野愛, 前田健.
    • Organizer
      第49回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      山口県山口市、ホテルニュータナカ
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 初代培養マウス脳細胞を用いた脳炎フラビウイルスの増殖機構の解析2013

    • Author(s)
      平野港, 好井健太朗, 境瑞紀, 長谷部理絵, 苅和宏明
    • Organizer
      第48回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      静岡県熱海市 ニューウェルシティ湯河原
    • Related Report
      2013 Annual Research Report
  • [Presentation] ダニ媒介性フラビウイルスによる中枢神経系病態に関わるウイルス因子の同定. 第48回日本脳炎ウイルス生態学研究会2013

    • Author(s)
      好井健太朗, 寸田祐嗣, 五十嵐学, 横澤香菜, 境瑞紀, 苅和宏明, Holbrook, M. R., 高島郁夫
    • Organizer
      第48回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      静岡県熱海市 ニューウェルシティ湯河原
    • Related Report
      2013 Annual Research Report
  • [Presentation] 境瑞紀, 好井健太朗, 横澤香菜, 苅和宏明. 極東型ダニ媒介性脳炎ウイルスの強毒化に関わるウイルス側因子の特定2013

    • Author(s)
      境瑞紀, 好井健太朗, 横澤香菜, 苅和宏明
    • Organizer
      第48回日本脳炎ウイルス生態学研究会
    • Place of Presentation
      静岡県熱海市 ニューウェルシティ湯河原
    • Related Report
      2013 Annual Research Report
  • [Presentation] 初代培養マウス脳細胞を用いた脳炎フラビウイルスの増殖機構の解析2013

    • Author(s)
      平野港, 好井健太朗, 境瑞紀, 長谷部理絵, 苅和宏明
    • Organizer
      日本ウイルス学会北海道支部会 第47回夏季シンポジウム
    • Place of Presentation
      北海道奈井江町 新ないえ温泉ホテル北の湯
    • Related Report
      2013 Annual Research Report
  • [Presentation] 初代培養マウス脳細胞を用いた脳炎フラビウイルスの増殖機構の解析2013

    • Author(s)
      平野港, 好井健太朗, 境瑞紀, 長谷部理絵, 苅和宏明
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜県岐阜市 岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] HantaanウイルスAA57株感染マウスにおける病態発現機序の解析2013

    • Author(s)
      牧雅大, 真田崇弘, 瀬戸隆弘, 永田典代, 好井健太郎, 苅和宏明
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜県岐阜市 岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 極東型ダニ媒介性脳炎ウイルスの強毒化に関わるウイルス側因子の特定2013

    • Author(s)
      境瑞紀, 好井健太朗, 横澤香菜, 苅和宏明
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜県岐阜市 岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ダニ媒介性フラビウイルスによる中枢神経系病態におけるNS5蛋白の影響の解析2013

    • Author(s)
      好井健太朗, 寸田祐嗣, 五十嵐学, 横澤香菜, 境瑞紀, 苅和宏明, Holbrook, M. R., 高島郁夫
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜県岐阜市 岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 山口県のイノシシからダニ媒介性脳炎ウイルス様遺伝子の検出2013

    • Author(s)
      下田宙, 早坂大輔, 好井健太朗, 米満研三, 寺田豊, 野口慧多, 鍬田龍星, 高野愛, 前田健
    • Organizer
      第20回 トガ・フラビ・ペスチウイルス研究会
    • Place of Presentation
      兵庫県神戸市 神戸国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 初代培養マウス脳細胞を用いた脳炎フラビウイルスの増殖機構の解析2013

    • Author(s)
      平野港, 好井健太朗, 境瑞紀, 長谷部理絵, 苅和宏明
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      兵庫県神戸市 神戸国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] HantaanウイルスAA57株感染マウスにおける病態発現機序の解析2013

    • Author(s)
      牧雅大, 真田崇弘, 瀬戸隆弘, 永田典代, 好井健太郎, 苅和宏明
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      兵庫県神戸市 神戸国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] ダニ媒介性フラビウイルスによる中枢神経系病態に関わるウイルス因子の同定2013

    • Author(s)
      好井健太朗, 寸田祐嗣, 五十嵐学, 横澤香菜, 境瑞紀, 苅和宏明, Holbrook, M. R., 高島郁夫
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      兵庫県神戸市 神戸国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 極東型ダニ媒介性脳炎ウイルスの強毒化に関わるウイルス側因子の特定2013

    • Author(s)
      境瑞紀, 好井健太朗, 横澤香菜, 苅和宏明
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      兵庫県神戸市 神戸国際会議場
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2022-01-31  

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