| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Outline of Final Research Achievements |
In Vietnam and Cambodia, we confirmed 3 different genotypes consists of genotypes 1, 2 and 6 were prevalent. In both countries, genotype 6 variants were most predominant (more than half), followed by genotype 1 and genotype 2. We identified multiple HCV lineages (6a/6e/6h/6k/6l/6o/6p) in Vietnam may represent the indigenous strains; 1a was probably introduced from the US; 1b and 2a possibly originated in East Asia; while 2i/2j/2m were likely brought by French explorers. Furthermore, we inferred the evolutionary history for four major subtypes (1a/1b/6a/6e). The obtained Bayesian Skyline Plots (BSPs) consistently showed the rapid HCV population growth from 1955 to 1963 until 1984 or after, corresponding to the era of theVietnam War. In addition, virological and pathological characteristics of hepatocellular carcinoma (HCC) in Vietnam and occurrence of occult B/C infection among non-B/non-C HCC patients in various countries were reported.
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