IgG responses to mosquito saliva proteins for evaluating human exposure to Anopheles bites
| Project/Area Number |
25305007
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 海外学術 |
|---|
| Research Field |
Parasitology (including sanitary zoology)
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TUNO NOBUKO 金沢大学, 自然システム系, 准教授 (60295102)
MATSUOKA HIROYUKI 自治医科大学, 医学部, 教授 (10173816)
IYORI MITSUHIRO 金沢大学, 医薬保健研究域薬学系, 准教授 (20608351)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
|---|
| Keywords | マラリア / ハマダラカ / 唾液タンパク質 / インドネシア / 疫学調査 / AAPP |
|---|
| Outline of Final Research Achievements |
The IgG Ab level to AAPP was evaluated before, during and after the rainy season in cohorts of residents in Sumba. IgG responses to malaria antigens were also examined. A total of 2,617 samples of the sera were analyzed for the Ab levels in comparison with malaria incidence. In the residents during the rainy season, IgG response against AAPP was significantly increased, and this response was significantly higher in the cohort of individuals infected with P. falciparum than those of parasite-free population. Throughout the seasons, IgG levels toward anti-malaria antigens from P. falciparum were significantly increased in the cohort of individuals infected with P. falciparum, but those against P. vivax antigens were relatively weak. Our result demonstrates that anti-AAPP IgG response reflects P. falciparum infection during rainy season in response to higher mosquito exposure; hence this biomarker can be a powerful tool for the evaluation of exposure to malaria vector mosquitoes.
|
Report
(4 results)
Research Products
(9 results)
-
-
[Journal Article] The crystal structure of the active domain of Anopheles anti-platelet protein, a powerful anti-coagulant, in complex with an antibody.2014
Author(s)
Sugiyama, K., Iyori, M., Sawaguchi, A., Akashi, S., Tame, J.R.H., Park, S.-Y., Yoshida, S.
-
Journal Title
J. Biol. Chem.
Volume: 289
Issue: 23
Pages: 16303-16312
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
