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Comparable studies on HTLV-1 associated diseases between costal area of Fujian province, China, and south-western Japan.

Research Project

Project/Area Number 25305017
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Virology
Research InstitutionKagoshima University

Principal Investigator

Izumo Shuji  鹿児島大学, 医歯学総合研究科, 客員研究員 (30143811)

Co-Investigator(Kenkyū-buntansha) 有馬 直道  鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (30175997)
蓮井 和久  鹿児島大学, 医歯(薬)学総合研究科, 客員研究員 (70198703)
久保田 龍二  鹿児島大学, 医歯学域医学系, 准教授 (70336337)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
KeywordsHTLV-1 / 国際研究者交流 / 中国福建省 / HTLV-1関連脊髄症 / 成人T細胞白血病・リンパ腫 / 脳神経疾患 / 疫学
Outline of Final Research Achievements

HTLV-1 is distributed worldwide, and Fujian province is an only area where HTLV-1-positive blood donors were found in China. But information of HTLV-1 in China is limited, and there are few reports about patients with HTLV-1-associated diseases from China. This project is planned to encourage and support HTLV-1 study in Fujian province China, in order to find the patients, find HTLV-1-hot areas, and begin original HTLV-1 researches in China.
We invited Chinese researchers to Japan for training of HTLV-1 study. We also visited regional center hospitals and blood centers in Fujian province and give lectures about HTLV-1 related diseases. As a result, HTLV-1 infection was found to be endemic in the coastal area of Fujian province, especially in northern region, where several ATL patients have been experienced. In addition, one HAM/TSP patient with typical clinical features was confirmed by international diagnostic criteria. HTLV-1 is endemic in the coastal area of Fujian province, China.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (27 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (17 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results) Book (3 results) Remarks (2 results)

  • [Int'l Joint Research] Medical College of Xiamen University/2nd Affil. Hosp. Fujian Medical Univ./Quanzhou Blood Center(China)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] 厦門大学医学院/福建医科大学(中国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression.2016

    • Author(s)
      Matsuura E, Nozuma S, Tashiro Y, Kubota R, Izumo S, Takashima H
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 371 Pages: 112-116

    • DOI

      10.1016/j.jns.2016.10.030

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis.2015

    • Author(s)
      Matsuura E, Kubota R, Tanaka Y, Takashima H, Izumo S
    • Journal Title

      J Neuropath Exp Neurol.

      Volume: 74 Issue: 1 Pages: 2-14

    • DOI

      10.1097/nen.0000000000000141

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis.2014

    • Author(s)
      Nozuma S, Matsuura E, Matsuzaki T, Watanabe O, Kubota R, Izumo S, Takashima H
    • Journal Title

      PLoS One

      Volume: 9 Issue: 5 Pages: e86144-e86144

    • DOI

      10.1371/journal.pone.0086144

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ER Stress Response Induced by Inhibition of GRP94 or LacNAc synthetase B3GnT2 in CD4+T Cells of HAM/TSP2017

    • Author(s)
      Kodama D, Matsuzaki T, Takashima H, Kubota R
    • Organizer
      18th International Conference on Human Retrovirology:
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gene Expression Profile of Activated HTLV-1-Infected Cells from HAM/TSP Patients2017

    • Author(s)
      Kubota R, Kodama D, Takashima H
    • Organizer
      18th International Conference on Human Retrovirology:
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中国福健省でHAMを探す:中日共同研究2017

    • Author(s)
      ケイ惠琴、高宏志、コク肇績、叶翔、許芥平、鄭維紅、久保田龍二、出雲周二
    • Organizer
      第2回鹿児島大学感染症制御のためのシンポジウム 特別講演
    • Place of Presentation
      鹿児島大学鶴陵会館(鹿児島県鹿児島市)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HAMの発症病態:わかったことと、わからないこと2016

    • Author(s)
      出雲周二
    • Organizer
      第28回日本神経免疫学会学術集会
    • Place of Presentation
      長崎市ブリックホール(長崎県長崎市)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] HAM患者HTLV-1感染細胞のウイルス活性化時の遺伝子変動2016

    • Author(s)
      久保田龍二、高嶋 博
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 中国福健省でHAMを探す:中日共同研究中間報告-22016

    • Author(s)
      ケイ惠琴、高洪志、コク肇績、彭鋒、叶翔、許芥平、テイ小把、鄭維紅、久保田龍二、出雲周二
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] HAM患者CD4+ T細胞へのGRP94阻害薬、N-アセチルラクトサミン合成酵素B3GnT2阻害薬による小胞体ストレス応答2016

    • Author(s)
      児玉大介、久保田龍二、松崎敏男、高嶋 博、出雲周二
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 中国福建省でHTLV-1関連疾患を探る2016

    • Author(s)
      出雲周二
    • Organizer
      海外学術調査フォーラム2016
    • Place of Presentation
      東京外国語大学アジア・アフリカ言語文化研究所(東京都府中市)
    • Year and Date
      2016-07-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Resistance against ER stress in CD4+ T cells of HAM2016

    • Author(s)
      児玉大介、久保田龍二、松崎敏男、高嶋博、出雲周二
    • Organizer
      第57回日本神経学会学術集会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Gene expression profile of activated HTLV-1-infected cells from HAM patients2016

    • Author(s)
      久保田龍二、高嶋 博、出雲周二
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-05-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] HTLV-1関連脊髄症(HAM) 発見の経緯、疫学、病理について2015

    • Author(s)
      出雲周二
    • Organizer
      第4回中国・台湾合同神経内科フォーラム
    • Place of Presentation
      厦門市 (中国)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] HTLV-1関連脊髄症(HAM)の臨床と治療2015

    • Author(s)
      久保田龍二
    • Organizer
      第4回中国・台湾合同神経内科フォーラム
    • Place of Presentation
      厦門大学附属中山医院 厦門市(中国)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 中国福建省でHTLV-1関連疾患を探す中日共同研究2015

    • Author(s)
      けい惠琴, 劉肇績, 彭鋒, 唐栄, 張玉, 叶翔, 許斉平, 鄭維紅, 出雲周二
    • Organizer
      第2回日本HTLV-1学会
    • Place of Presentation
      東京大学医科学研究所 (東京都港区)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] The prevalence of human T Lymphotropic virus infection among blood donors in southeast China, 2004-20132015

    • Author(s)
      Zhang Ya-Li, Chen Chang-rong
    • Organizer
      第2回日本HTLV-1学会
    • Place of Presentation
      東京大学医科学研究所 (東京都港区)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] HTLV-1 HBZ特異的CTLのエピトープ同定とHAMにおける検出2014

    • Author(s)
      久保田龍二、松﨑敏男、高嶋 博、出雲周二
    • Organizer
      第19回日本神経感染症学会学術集会
    • Place of Presentation
      金沢市(金沢歌劇座)
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] HAMにおけるHTLV-1抗原遺伝子変異とCTL認識2014

    • Author(s)
      久保田龍二、齊藤峰輝、高嶋 博、出雲周二
    • Organizer
      第1回日本HTLV-1学会学術集会
    • Place of Presentation
      東京都(東京大学医科学研究所)
    • Year and Date
      2014-08-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] HAMにおけるHTLV-1 HBZ特異的CTLの検出2014

    • Author(s)
      久保田龍二、松﨑敏男、高嶋 博、出雲周二
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市(福岡国際会議場)
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Book] 慢性炎症とリンパ腫発症(2015.10増刊号「リンパ腫学 –最新の研究動向)2015

    • Author(s)
      蓮井和久
    • Total Pages
      4
    • Publisher
      日本臨床社
    • Related Report
      2014 Annual Research Report
  • [Book] 神経疾患 最新の治療 2015-2017。小林祥泰/水澤英洋/山口修平 編集。ヒトTリンパ球向性ウイルス脊髄症(HAM)2015

    • Author(s)
      久保田龍二
    • Total Pages
      3
    • Publisher
      南江堂
    • Related Report
      2014 Annual Research Report
  • [Book] アクチュアル脳・神経疾患の臨床 神経感染症を究める 辻省次・水澤英洋 編集 HTLV-1感染症2014

    • Author(s)
      出雲周二
    • Total Pages
      7
    • Publisher
      中山書店
    • Related Report
      2014 Annual Research Report
  • [Remarks] 中国のHTLV-1関連疾患の研究に伴い日中関係の歴史について考える

    • URL

      http://www.ab.auone-net.jp/~khasui/HTLVASIA/HTLVASIA.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 中国のHTLV-1関連疾患の研究に伴い日中関係の歴史について考える

    • URL

      http://www.ab.auone-net.jp/~khasui/HTLVASIA/HTLVASIA.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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