Development of screening methods for early detection of nasopharyngeal carcinoma in southern China

• Project/Area Number: 25305020
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Hygiene and public health
• Research Institution: Mie University
• Principal Investigator: Murata Mariko 三重大学, 医学(系)研究科(研究院), 教授 (10171141)
• Co-Investigator(Kenkyū-buntansha): OIKAWA SHINJI 三重大学, 大学院医学系研究科, 准教授 (10277006) ; HIRAKU YUSUKE 三重大学, 大学院医学系研究科, 講師 (30324510) ; MA NEI 鈴鹿医療科学大学, 看護学部, 教授 (30263015) ; MIDORIKAWA KAORU 三重大学, 大学院医学系研究科, リサーチアソシエイト (20393366)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 癌 / DNAメチル化 / microRNA / バイオマーカー / 中国南部 / 早期診断法

Outline of Final Research Achievements

Nasopharyngeal carcinoma (NPC) is a malignancy with poor prognosis that is endemic to Southern China. We investigated epigenetic alteration in NPC to find biomarker candidates for early detection. We obtained specimens from NPC patients and control subjects written informed consent. DNA and RNA were extracted and analyzed the differences in levels of DNA methylation and microRNA expression. We found promoter hypermethylation (UBE2L6, FSTL1, etc.) and dysregulation of microRNA (down-regulation of miR-497, up-regulation of ebv-miR-BART22, etc.). Furthermore, the concordant down-regulation of miR-497 in tissues and plasma suggested that miR-497 could be used as a diagnostic biomarker for NPC. Treatment with demethylation reagents and transfection of miR-497 mimic restored the gene expression levels, and inhibited cancer phenotypes (cell proliferation and migration and anti-apoptosis) in NPC.

Research Products

• [Int'l Joint Research] 広西医科大学(中国)
• [Journal Article] Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation. (2016)
  • Author(s): Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M.
  • Journal Title: Part Fibre Toxicol. Volume: 13 Issue: 1 Pages: 16-16
  • DOI: 10.1186/s12989-016-0127-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DNA Damage in CD133-Positive Cells in Barrett's Esophagus and Esophageal Adenocarcinoma. (2016)
  • Author(s): Thanan R, Ma N, Hiraku Y, Iijima K, Koike T, Shimosegawa T, Murata M, Kawanishi S.
  • Journal Title: Mediators Inflamm. Volume: 2016 Pages: 7937814-7937814
  • DOI: 10.1155/2016/7937814
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exposure assessment and heart rate variability monitoring in workers handling titanium dioxide particles-a pilot study. (2016)
  • Author(s): Ichihara S, Li W, Omura S, Fujitani Y, Liu Y, Wang Q, Hiraku Y, Hisanaga N, Wakai K, Ding X, Kobayashi T, Ichihara G.
  • Journal Title: J. Nanopart. Res. Volume: 18 Issue: 3 Pages: 52-52
  • DOI: 10.1007/s11051-016-3340-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epigenetic inactivation of follistatin-like 1 mediates tumor immune evasion in nasopharyngeal carcinoma. (2016)
  • Author(s): Zhou X, Xiao X, Huang T, Du C, Wang S, Mo Y, Ma N, Murata M, Li B, Wen W, Huang G, Zeng X, Zhang Z
  • Journal Title: Oncotarget Volume: 7 Issue: 13 Pages: 16433-16444
  • DOI: 10.18632/oncotarget.7654
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma. (2015)
  • Author(s): Zhou X, Wei J, Chen F, Xiao X, Huang T, He Q, Wang S, Du C, Mo Y, Lin L, Xie Y, Wei L, Lan Y, Murata M, Huang G, Ernberg I, Matskova L, Zhang Z.
  • Journal Title: Oncotarget. Volume: 6(38) Issue: 38 Pages: 41077-1091
  • DOI: 10.18632/oncotarget.6218
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L. (2015)
  • Author(s): Wang S, Mo Y, Midorikawa K, Zhang Z, Huang G, Ma N, Zhao W, Hiraku Y, Oikawa S, Murata M.
  • Journal Title: Oncotarget Volume: 6 Issue: 34 Pages: 35893-35907
  • DOI: 10.18632/oncotarget.5651
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development and characterization of a hydrogen peroxide-resistant cholangiocyte cell line: A novel model of oxidative stress-related cholangiocarcinoma genesis. (2015)
  • Author(s): Thanan R, Techasen A, Hou B, Jamnongkan W, Armartmuntree N, Yongvanit P, Murata M.
  • Journal Title: Biochem Biophys Res Commun. Volume: 64(1) Issue: 1 Pages: 182-188
  • DOI: 10.1016/j.bbrc.2015.06.112
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Oxidative DNA damage induced by metabolites of chloramphenicol, an antibiotic drug. (2015)
  • Author(s): Ohnishi S, Murata M, Ida N, Oikawa S, Kawanishi S.
  • Journal Title: Free Radic Res. Volume: 49 Issue: 9 Pages: 1165-1172
  • DOI: 10.3109/10715762.2015.1050963
  • Peer Reviewed
• [Journal Article] Changes of microRNAs in asymptomatic subjects sensitized to Japanese cedar pollen following prophylactic sublingual immunotherapy. (2015)
  • Author(s): Hou B, Murata M, Shah SA, Sakaida H, Masuda S, Takahashi T, Zhang Z, Takeuchi K.
  • Journal Title: Allergy Rhinol. Volume: 6 Issue: 1 Pages: 33-38
  • DOI: 10.2500/ar.2015.6.0107
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Reduced coenzyme Q10 decreases urinary of 8-oxo-7,8-dihydro-2’-deoxyguanosine concentrations in healthy young female subjects. (2015)
  • Author(s): Ito K, Watanabe C, Nakamura A, Oikawa-Tada S, Murata M.
  • Journal Title: J Med Food Volume: in press Issue: 8 Pages: 835-840
  • DOI: 10.1089/jmf.2014.3302
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma. (2015)
  • Author(s): Hou B, Ishinaga H, Midorikawa K, Shah SA, Nakamura S, Hiraku Y, Oikawa S, Murata M, Takeuchi K. Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma.
  • Journal Title: Cancer Biol. Ther. Volume: 16 Issue: 7 Pages: 1042-1046
  • DOI: 10.1080/15384047.2015.1045692
  • Peer Reviewed
• [Journal Article] Inflammation-related DNA damage in relation to the expression of cancer stemness markers in human nasopharyngeal carcinoma. (2015)
  • Author(s): Wang S, Ma N, Kawanishi S, Zhao W, Midorikawa K, Hiraku Y, Oikawa S, Zhang Z, Huang G, Murata M.
  • Journal Title: Free Radic Biol Med Volume: 86
  • Int'l Joint Research
• [Journal Article] Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma. (2015)
  • Author(s): Bo Hou, Hajime Ishinaga, Kaoru Midorikawa, Said Ahmad Shah, Satoshi Nakamura, Yusuke Hiraku, Shinji Oikawa, Mariko Murata, Kazuhiko Takeuchi
  • Journal Title: Cancer Biology & Therapy Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway (2015)
  • Author(s): Laothong U, Hiraku Y, Oikawa S, Intuyod K, Murata M, Pinlaor S.
  • Journal Title: Oncol Rep Volume: 33 Issue: 3 Pages: 1443-1449
  • DOI: 10.3892/or.2015.3738
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Proteomic analysis of carbonylated proteins in the monkey substantia nigra after ischemia-reperfusion. (2014)
  • Author(s): Oikawa S, Kobayashi H, Kitamura Y, Zhu H, Obata K, Minabe Y, Dazortsava M, Ohashi K, Tada-Oikawa S, Takahashi H, Yata K, Murata M, Yamashima T.
  • Journal Title: Free Radic Res Volume: 48 Issue: 6 Pages: 694-705
  • DOI: 10.3109/10715762.2014.901509
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Formation of the Nitrative DNA Lesion 8-Nitroguanine is Associated with Asbestos Contents in Human Lung Tissues: A Pilot Study (2014)
  • Author(s): Hiraku Y, Sakai K, Shibata E, Kamijima M, Hisanaga N, Ma N, Kawanishi S, Murata M
  • Journal Title: Journal of Occupational Health Volume: 56 Issue: 3 Pages: 186-196
  • DOI: 10.1539/joh.13-0231-OA
  • NAID: 130004447649
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metal-mediated oxidative DNA damage induced by methylene blue (2014)
  • Author(s): Hiraku Y, Goto H, Kohno M, Kawanishi S, Murata M
  • Journal Title: Biochim Biophys Acta Volume: 1840 Issue: 9 Pages: 2776-2782
  • DOI: 10.1016/j.bbagen.2014.04.020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationships of alpha-SMA-positive fibroblasts and SDF-1-positive tumor cells with neoangiogenesis in nasopharyngeal carcinoma (2014)
  • Author(s): Wang S, Ma N, Kawanishi S, Hiraku Y, Oikawa S, Xie Y, Zhang Z, Huang G, Murata M
  • Journal Title: Biomed Res Int Volume: 2014 Pages: 507353-507353
  • DOI: 10.1155/2014/507353
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oxidative stress and its significant roles in neurodegenerative diseases and cancer. (2014)
  • Author(s): Thanan R, Oikawa S, Hiraku Y, Ohnishi S, Ma N, Pinlaor S, Yongvanit P, Kawanishi S, Murata M
  • Journal Title: Int J Mol Sci Volume: 16 Issue: 1 Pages: 193-217
  • DOI: 10.3390/ijms16010193
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of nitrative DNA damage in inflammation-related carcinogenesis. (2014)
  • Author(s): Hiraku Y, Kawanishi S.
  • Journal Title: Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects. Hiraku Y, Kawanishi S, Ohshima H (ed.). Wiley Volume: - Pages: 41-59
  • Peer Reviewed
• [Journal Article] 環境因子による酸化・ニトロ化DNA損傷と発がんリスク評価 (2014)
  • Author(s): 平工雄介
  • Journal Title: 福岡医学雑誌 Volume: 105 Pages: 33-41
  • NAID: 120005438022
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationships of alpha-SMA-positive fibroblasts and SDF-1-positive tumor cells to neoangiogenesis in nasopharyngeal carcinoma. (2014)
  • Author(s): Wang S, Ma N, Kawanishi S, Hiraku Y, Oikawa S, Xie Y, Zhang Z, Huang G, Murata M.
  • Journal Title: BioMed Research International Volume: -
  • Peer Reviewed
• [Journal Article] Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat (2014)
  • Author(s): Chang J, Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Aoki C, Yamada Y, Ichihara G, Kato M, Ichihara S
  • Journal Title: Diabetol Metab Syndr Volume: 6(1) Issue: 1 Pages: 8-8
  • DOI: 10.1186/1758-5996-6-8
  • Peer Reviewed / Open Access
• [Journal Article] Oxidative DNA damage and mammary cell proliferation by alcohol-derived salsolinol. (2013)
  • Author(s): Murata M, Midorikawa K, Kawanishi S.
  • Journal Title: Chem Res Toxicol. Volume: 26 Issue: 10 Pages: 1455-1463
  • DOI: 10.1021/tx400182n
  • Peer Reviewed
• [Journal Article] Inflammation-related DNA damage and expression of CD133 and Oct3/4 in cholangiocarcinoma patients with poor prognosis (2013)
  • Author(s): Thanan R, Pairojkul C, Pinlaor S, Khuntikeo N, Wongkham C, Sripa B, Ma N, Vaeteewoottacharn K, Furukawa A, Kobayashi H, Hiraku Y, Oikawa S, Kawanishi S, Yongvanit P, Murata M
  • Journal Title: Free Radic Biol Med Volume: 65 Pages: 1464-1472
  • DOI: 10.1016/j.freeradbiomed.2013.07.034
  • Peer Reviewed
• [Journal Article] DNA damage in inflammation-related carcinogenesis and cancer stem cells (2013)
  • Author(s): Ohnishi S, Ma N, Thanan R, Pinlaor S, Hammam O, Murata M, Kawanishi S.
  • Journal Title: Oxid Med Cell Longev. Volume: - Pages: 1-9
  • DOI: 10.1155/2013/387014
  • Peer Reviewed
• [Journal Article] Endocrine disruptors found in food contaminants enhance allergic sensitization through an oxidative stress that promotes the development of allergic airway inflammation. (2013)
  • Author(s): Kato T, Tada-Oikawa S, Wang L, Murata M, Kuribayashi K.
  • Journal Title: Toxicol Appl Pharmacol. Volume: 273 Issue: 1 Pages: 10-18
  • DOI: 10.1016/j.taap.2013.08.029
  • Peer Reviewed
• [Presentation] 環境因子とマイクロRNA：DOHaD研究への応用と展望 (2016)
  • Author(s): 平工雄介
  • Organizer: 第86回日本衛生学会総会
  • Place of Presentation: 旭川市民文化会館（北海道旭川市）
  • Year and Date: 2016-05-11
  • Invited
• [Presentation] インジウム曝露ラット肺におけるマイクロRNA発現の網羅的解析と標的遺伝子の探索 (2016)
  • Author(s): 平工雄介、田中昭代、平田美由紀、村田真理子
  • Organizer: 第86回日本衛生学会総会
  • Place of Presentation: 旭川市民文化会館（北海道旭川市）
  • Year and Date: 2016-05-11
• [Presentation] パーキンソン病患者の血漿中エクソソームを用いたバイオマーカーの探索 (2016)
  • Author(s): 北村祐貴、佐々木良元、市原佐保子、埜村智之、石川雅一、水野章、村田真理子、冨本秀和、及川伸二
  • Organizer: 第86回日本衛生学会総会
  • Place of Presentation: 旭川市民文化会館（北海道旭川市）
  • Year and Date: 2016-05-11
• [Presentation] インジウム化合物で処理したマクロファージ培養細胞におけるニトロ化DNA損傷 (2016)
  • Author(s): Tahmina Afroz、馬寧、川西正祐、村田真理子、平工雄介
  • Organizer: 第86回日本衛生学会総会
  • Place of Presentation: 旭川市民文化会館（北海道旭川市）
  • Year and Date: 2016-05-11
• [Presentation] Let-7c functions as a tumor suppressor by targeting IGF1R in head and neck cancer. (2016)
  • Author(s): Bo Hou, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Ning Ma, Mariko Murata.
  • Organizer: 第86回日本衛生学会総会
  • Place of Presentation: 旭川市民文化会館（北海道旭川市）
  • Year and Date: 2016-05-11
• [Presentation] Hypermethylation of RERG promoter in nasopharyngeal carcinoma. (2016)
  • Author(s): Weilin Zhao, Shumin Wang, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata.
  • Organizer: 第86回日本衛生学会総会
  • Place of Presentation: 旭川市民文化会館（北海道旭川市）
  • Year and Date: 2016-05-11
• [Presentation] パーキンソン病患者血漿中の酸化損傷タンパク質の解析 (2016)
  • Author(s): 北村祐貴、佐々木良元、市原佐保子、埜村智之、石川雅一、水野章、村田真理子、冨本秀和、及川伸二
  • Organizer: 日本酸化ストレス学会東海支部第4回学術大会
  • Place of Presentation: 鈴鹿医療科学大学(三重県鈴鹿市）
  • Year and Date: 2016-02-06
• [Presentation] NNK誘導マウス肺がんに対するサルナシ果汁の肺発がん抑制効果における比較プロテオミクス解析 (2015)
  • Author(s): 北村祐貴、三宅直子、有元佐賀惠、村田真理子、及川伸二
  • Organizer: 第44回日本環境変異原学会
  • Place of Presentation: 九州大学馬出キャンパス(福岡県福岡市）
  • Year and Date: 2015-11-27
• [Presentation] インジウム曝露ラット肺におけるマイクロRNA発現の解析と標的遺伝子の探索 (2015)
  • Author(s): 平工雄介、黒澤長之、田中昭代、平田美由紀、村田真理子
  • Organizer: 日本産業衛生学会東海地方会
  • Place of Presentation: 名古屋大学医学部（愛知県名古屋市）
  • Year and Date: 2015-11-14
• [Presentation] 早期アルツハイマー病患者の血漿中バイオマーカーの探索 (2015)
  • Author(s): 北村祐貴、本城貴志、山嶋哲盛、及川伸二
  • Organizer: 第24回海馬と高次脳機能学会
  • Place of Presentation: 岐阜大学サテライトキャンパス(岐阜県岐阜市）
  • Year and Date: 2015-10-10
• [Presentation] Early B cell factor 1 down-regulation mechanisms and their significance in cholangiocarcinoma prognosis. (2015)
  • Author(s): Napat Armartmuntree、Chakkaphan Khenjanta、Wassana Jamnongkan、Anchalee Techasen、Watcharin Loilome、Nisana Namwat、Somchai Pinlaor、Chawalit Pairojkul、Puangrat Yongvanit、Murata, Mariko、Thanan, Raynoo
  • Organizer: 第74 回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Genome-wide profiling of DNA methylation identifies oxidative stress-induced epigenetic targets in cholangiocarcinoma. (2015)
  • Author(s): Raynoo Thanan、Somchai Pinlaor、Umawadee Laothong、Puangrat Yongvanit、Ning Ma、Shosuke Kawanishi、Mariko Murata
  • Organizer: 第74 回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] 頭頸部扁平上皮癌におけるマイクロRNA let-7c とその標的遺伝子の役割. (2015)
  • Author(s): 侯波、石永一、翠川薫、王淑民、趙蔚林、及川伸二、平工雄介、馬寧、竹内万彦、村田真理子
  • Organizer: 第74 回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] 上咽頭癌における癌抑制遺伝子候補のプロモーター領域DNA の高度メチル化. (2015)
  • Author(s): 趙蔚林、王淑民、翠川薫、張哲、莫頴禧、黄光武、馬寧、平工雄介、及川伸二、村田真理子
  • Organizer: 第74 回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Nitrative DNA damage in lung epithelilal cells treated with multi-walled carbon nanotube: role of Toll-like receptor 9 (2015)
  • Author(s): Yusuke Hiraku, Ning Ma, Shumin Wang, Shosuke Kawanishi, Mariko Murata
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Inflammation-related DNA damage in relation to the expression of cancer stemness markers in human nasopharyngeal carcinoma. (2015)
  • Author(s): Wang S, Ma N, Kawanishi S, Zhao W, Midorikawa K, Hiraku Y, Oikawa S, Zhang Z, Huang G, Murata M.
  • Organizer: SFRR-E/SNFS Meeting Stuttgart 2015: Redox Biology Meets Nutrition,
  • Place of Presentation: ホ－エンハイム大学,シュトゥットガルト(ドイツ)
  • Year and Date: 2015-09-01
  • Int'l Joint Research
• [Presentation] 筋萎縮性側索硬化症の脳脊髄液におけるカルボニル化タンパク質の解析 (2015)
  • Author(s): 北村祐貴、菰田淳、二本松綾乃、佐々木良元、村田真理子、冨本秀和、及川伸二
  • Organizer: 日本プロテオーム学会2015年会
  • Place of Presentation: 熊本森都心プラザ(熊本県熊本市）
  • Year and Date: 2015-07-23
• [Presentation] Novel circulating microRNA biomarkers for head and neck squamous cell carcinoma. (2015)
  • Author(s): Bo Hou, Hajime Ishinaga, Said Ahmad Shah, Satoshi Nakamura, Kaoru Midorikawa, Mariko Murata, Kazuhiko Takeuchi.
  • Organizer: 4th Congress of Asian Society of Head and Neck Oncology
  • Place of Presentation: 神戸国際会議場,(兵庫県神戸市）
  • Year and Date: 2015-06-03
  • Int'l Joint Research
• [Presentation] Possible roles of circulating microRNAs during prophylactic sublingual immunotherapy. (2015)
  • Author(s): Bo Hou, Mariko murata, Hiroshi Sakaida, Sawako Masuda, Kazuhiko Takeuchi.
  • Organizer: 第64回日本アレルギー学会学術大会
  • Place of Presentation: グランドプリンスホテル新高輪 国際館パミール(東京都港区)
  • Year and Date: 2015-05-26
• [Presentation] インジウム曝露ラット肺におけるマイクロRNA発現の網羅的解析 (2015)
  • Author(s): 平工雄介、田中昭代、平田美由紀、村田真理子
  • Organizer: 第88回日本産業衛生学会
  • Place of Presentation: グランフロント大阪（大阪府大阪市）
  • Year and Date: 2015-05-13
• [Presentation] 多層カーボンナノチューブによる細胞内ニトロ化DNA損傷：Toll様受容体の関与 (2015)
  • Author(s): 平工雄介、山田達彦、馬寧、川西正祐、村田真理子
  • Organizer: 第85回日本衛生学会総会
  • Place of Presentation: 和歌山県民文化会館・ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Identification of inflammation-related DNA damage and cancer stem cell marker in the nasopharyngeal carcinoma (2015)
  • Author(s): Shumin Wang, Ning Ma, Shosuke Kawanishi, Weilin Zhao, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第85回日本衛生学会総会
  • Place of Presentation: 和歌山県民文化会館・ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Glutaredoxin 3 involved in molecular mechanism of cisplatin-induced cytotoxicity in nasopharyngeal carcinoma (2015)
  • Author(s): Bo Hou, Kaoru Midorikawa, Ning Ma, Shumin Wang, Weilin Zhao, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第85回日本衛生学会総会
  • Place of Presentation: 和歌山県民文化会館・ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] アルツハイマー病患者の血漿中におけるプロテオミクス解析 (2015)
  • Author(s): 北村 祐貴、宇佐美 良子、木田 博隆、佐藤 正之、市原 佐保子、松永 誠治郎、 水野 章、冨本 秀和、村田 真理子、及川 伸二
  • Organizer: 第85回日本衛生学会総会
  • Place of Presentation: 和歌山県民文化会館・ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Genome-wide identification of promoter hypermethylation for candidate tumor suppressor genes in nasopharyngeal carcinoma (2015)
  • Author(s): Weilin Zhao, Shumin Wang, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第85回日本衛生学会総会
  • Place of Presentation: 和歌山県民文化会館・ホテルアバローム紀の国（和歌山市）
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] Circulating microRNA alterations in asymptomatic subjects sensitized to Japanese cedar pollen following prophylactic sublingual immunotherapy (2015)
  • Author(s): Bo Hou, Mariko Murata, Said Ahmad Shah, Hiroshi Sakaida, Sawako Masuda, Kazuhiko Takeuchi
  • Organizer: 第33回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 東武ホテルレバント（東京）
  • Year and Date: 2015-02-26 – 2015-02-28
• [Presentation] 多層カーボンナノチューブによるニトロ化DNA損傷とToll様受容体の役割 (2015)
  • Author(s): 平工雄介、山田達彦、馬寧、川西正祐、村田真理子
  • Organizer: 第14回分子予防環境医学研究会
  • Place of Presentation: 大阪市立大学（大阪市）
  • Year and Date: 2015-02-13 – 2015-02-14
• [Presentation] パーキンソン病患者の血漿におけるプロテオミクス解析 (2015)
  • Author(s): 北村 祐貴、都築 政弘、佐々木 良元、市原 佐保子、松永 誠治郎、水野 章、 村田 真理子、冨本 秀和、及川 伸二
  • Organizer: 日本酸化ストレス学会東海支部第3回学術大会
  • Place of Presentation: 名城大学（名古屋市）
  • Year and Date: 2015-02-07
• [Presentation] 多層カーボンナノチューブによる細胞内DNA損傷の解析(第3報): リソソーム内Toll様受容体の役割 (2014)
  • Author(s): 平工雄介、山田達彦、馬寧、村田真理子
  • Organizer: 日本産業衛生学会東海地方会
  • Place of Presentation: 三重大学（津市）
  • Year and Date: 2014-11-22
• [Presentation] アスベスト曝露マウスの肺組織におけるマイクロRNA発現の解析(第2報): 発がんへの関与の可能性 (2014)
  • Author(s): 渡辺純、金子晟、市瀬孝道、村田真理子、平工雄介
  • Organizer: 日本産業衛生学会東海地方会
  • Place of Presentation: 三重大学（津市）
  • Year and Date: 2014-11-22
• [Presentation] アルツハイマー病患者の血漿中のバイオマーカーの探索 (2014)
  • Author(s): 北村 祐貴、宇佐美 良子、紙本 貴之、木田 博隆、佐藤 正之、冨本 秀和、 及川 伸二
  • Organizer: 第23回海馬と高次脳機能学会
  • Place of Presentation: 湯涌創作の森（金沢市）
  • Year and Date: 2014-10-11 – 2014-10-12
• [Presentation] Alteration in miRNA expression in the lung of asbestos-exposed mice (2014)
  • Author(s): 平工雄介、市瀬孝道、村田真理子
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Differentially expressed microRNAs and their target genes in nasopharyngeal carcinoma (2014)
  • Author(s): Shumin Wang, Yingxi Mo, Kaoru Midorikawa, Zhe Zhang ,Guangwu Huang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Circulating microRNAs as biomarkers for response of head and neck squamous cell carcinoma to therapy (2014)
  • Author(s): Bo Hou, Hajime Ishinaga, Said Ahmad Shah, Kaoru Midorikawa, Shinji Oikawa, Yusuke Hiraku, Kazuhiko Takeuchi, Mariko Murata
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Genome-wide CpG island methylation analyses in nasopharyngeal carcinoma patients (2014)
  • Author(s): Weilin Zhao, Shumin Wang, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 虚血再灌流による酸化ストレス暴露サル黒質におけるタンパク質の変動解析 (2014)
  • Author(s): 北村 祐貴、山嶋 哲盛、村田 真理子、及川 伸二
  • Organizer: 第67回日本酸化ストレス学会学術集会
  • Place of Presentation: 同志社大学今出川キャンパス（京都市）
  • Year and Date: 2014-09-04 – 2014-09-05
• [Presentation] プロテオミクス解析を用いた虚血再灌流後のサル黒質におけるカルボニル化タンパク質の同定 (2014)
  • Author(s): 北村 祐貴、山嶋 哲盛、村田 真理子、及川 伸二
  • Organizer: 日本プロテオーム学会2014年会
  • Place of Presentation: つくば国際会議場（つくば市）
  • Year and Date: 2014-07-17 – 2014-07-18
• [Presentation] アスベスト気管内投与マウスの肺組織におけるマイクロRNA発現の解析 (2014)
  • Author(s): 平工雄介、市瀬孝道、村田真理子
  • Organizer: 第84回日本衛生学会総会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] Genome-wide methylation profiling of DNA methylation in nasopharyngeal carcinoma (2014)
  • Author(s): Weilin Zhao, Shuming Wang, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第84回日本衛生学会総会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] The interaction of cancer-associated fibroblasts and tumor cells with endothelial progenitor cells may facilitate angiogenesis in nasopharyngeal carcinoma (2014)
  • Author(s): Shumin Wang, Ning Ma, Shosuke Kawanishi, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第84回日本衛生学会総会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] パーキンソン病患者の血漿中カルボニル化タンパク質の同定 (2014)
  • Author(s): 北村祐貴, 都築政弘, 佐々木良元, 市原佐保子, 松永 誠治郎, 水野章, 村田真理子, 冨本 秀和, 及川 伸二
  • Organizer: 第84回日本衛生学会総会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] MicroRNA alterations in pollinosis development under prophylactic sublingual immunotherapy (2014)
  • Author(s): Bo Hou, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第84回日本衛生学会総会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] ヒト肺組織におけるニトロ化DNA損傷と石綿繊維量の関連および繊維長の影響 (2014)
  • Author(s): 平工雄介、酒井潔、柴田英治、上島通浩、久永直見、村田真理子
  • Organizer: 第87回日本産業衛生学会
  • Place of Presentation: 岡山コンベンションセンター・岡山シティミュージアム（岡山市）
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] パーキンソン病における血漿タンパク質の酸化損傷度解析 (2014)
  • Author(s): 都築政弘、佐々木良元、市原佐保子、松永誠治郎、水野章、村田真理子、冨本秀和、及川伸二
  • Organizer: 日本酸化ストレス学会東海支部 第２回学術大会
  • Place of Presentation: 岐阜薬科大学本部学舎（岐阜市）
• [Presentation] Proteomic analysis of carbonylated proteins in the substantia nigra of Japanese monkey after ischemia-reperfusion (2014)
  • Author(s): Yuki Kitamura, Tetsumori Yamashima , Mariko Murata, Shinji Oikawa
  • Organizer: SFRRI 2014 (17th Biennial Meeting of the Society for Free Radical Research International)
  • Place of Presentation: 京都国際会館(京都市)
• [Presentation] Genome-wide methylation profiling of DNA methylation in nasopharyngeal carcinoma (2014)
  • Author(s): Weilin Zhao, Shuming Wang, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] The interaction of cancer-associated fibroblasts and tumor cells with endothelial progenitor cells may facilitate angiogenesis in nasopharyngeal carcinoma (2014)
  • Author(s): Shumin Wang, Ning Ma, Shosuke Kawanishi, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Presentation] ナノ素材のリスク評価に関する基礎的研究(第3報)：多層カーボンナノチューブによる細胞内ニトロ化DNA損傷の解析 (2013)
  • Author(s): 平工雄介、村田真理子
  • Organizer: 第86回日本産業衛生学会
  • Place of Presentation: ひめぎんホール愛媛県県民文化会館）松山市（ひめぎんホール（愛媛県県民文化会館）(松山市）
• [Presentation] 多層カーボンナノチューブによる細胞内8-ニトログアニン生成(第2報)：繊維長のDNA損傷能への影響 (2013)
  • Author(s): 平工雄介、Feiye Guo、馬寧、川西正祐、村田真理子
  • Organizer: 第13回日本NO学会学術集会
  • Place of Presentation: 沖縄県医師会館（沖縄・南風原町）
• [Presentation] 環境因子による酸化・ニトロ化DNA損傷と発がんリスク評価 (2013)
  • Author(s): 平工雄介
  • Organizer: 第11回医工連携ゼミ
  • Place of Presentation: 九州大学病院キャンパス（福岡市）
  • Invited
• [Presentation] Proteomic analysis of the monkey hippocampal DG after the ischemia-reperfusion (2013)
  • Author(s): Yuki Kitamura, Shinji Oikawa, Tetsumori Yamashima, Mariko Murata
  • Organizer: HUPO 2013 (12th Human Proteome Organization World Congress)
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] パーキンソン病患者の血漿における酸化損傷タンパク質の同定 (2013)
  • Author(s): 都築政弘、北村祐貴、栗本将多、山嶋哲盛、及川伸二
  • Organizer: 第22回海馬と高次脳機能学会
  • Place of Presentation: 湯涌（ゆわく）創作の森 「交流研修棟」(金沢市）
• [Presentation] Analysis of microRNA dysregulation and target genes in nasopharyngeal carcinoma (2013)
  • Author(s): Shumin Wang, Yingxi Mo, Kaoru Midorikawa, Zhe Zhang ,Guangwu Huang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第72回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] MicroRNA alterations in head and neck squamous cell carcinoma (2013)
  • Author(s): Bo Hou, Hajime Ishinaga, Said Ahmad Shah, Shumin Wang, Kaoru Midorikawa, Ning Ma, Zhe Zhang, Mariko Murata, Kazuhiko Takeuchi
  • Organizer: 第72回日本癌学会総会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] アスベスト曝露マウスの肺組織におけるマイクロRNA発現の解析 (2013)
  • Author(s): 平工雄介、市瀬孝道、吉田成一、定金香里、村田真理子
  • Organizer: 日本産業衛生学会東海地方会
  • Place of Presentation: 愛知医科大学（長久手市）
• [Presentation] Nitrative DNA damage in lung epithelial cells exposed to multi-walled carbon nanotube (2013)
  • Author(s): Yusuke Hiraku, Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata
  • Organizer: 6th International Symposium on Nanotechnology, Occupational and Environmental Health,
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 天然色素purpurinによるDNA損傷機構 (2013)
  • Author(s): 北村祐貴、及川伸二、福嶋綾、川西正祐、村田真理子
  • Organizer: 第42回日本環境変異原学会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
• [Book] Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series. (2016)
  • Author(s): Murata M, Midorikawa K, Kawanishi S.
  • Total Pages: 376
  • Publisher: Vinood Patel. Elsevier Science & Technology