| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Helicobacter pylori CagA protein is considered to be one of the virulence factors associated with gastric cancer. Two major subtypes of CagA have been observed, the Western and East Asian types. The prevalence of the East Asian CagA-positive strain is associated with the mortality rate of gastric cancer in Asia. A phylogenetic tree of concatenated well-defined core genes supported divergence of the East Asian lineage from the European lineage ancestor, and then from the Amerind lineage ancestor. Greater divergence was observed in the genes of outer membrane proteins and lipopolysaccharide synthesis.
Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue lymphomas. CXCL13 was highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients. CXCL13 neutralization interfered with the formation of gastric lymphoid follicles.
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