Management of Helicobacter infection and its related gastrointestinal diseases in Asia
Project/Area Number |
25305027
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Gastroenterology
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Research Institution | Kobe University |
Principal Investigator |
AZUMA Takeshi 神戸大学, 医学(系)研究科(研究院), 教授 (60221040)
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Co-Investigator(Kenkyū-buntansha) |
HOSHI Namiko 神戸大学, 医学部附属病院, 助教 (40645214)
MORITA Yoshinori 神戸大学, 医学部附属病院, 講師 (60420460)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
Keywords | へリコバクターピロリ菌 / ヘリコバクタースイス菌 / 胃がん / 胃マルトリンパ腫 / ヘリコバクターピロリ / ヘリコバクタースイス / 胃・十二指腸潰瘍 / 胃MALTリンパ腫 / 国際情報交換(フィリピン) / 国際情報交換(中国) / 国際情報交換 / フィリピン / 中国 |
Outline of Final Research Achievements |
Helicobacter pylori CagA protein is considered to be one of the virulence factors associated with gastric cancer. Two major subtypes of CagA have been observed, the Western and East Asian types. The prevalence of the East Asian CagA-positive strain is associated with the mortality rate of gastric cancer in Asia. A phylogenetic tree of concatenated well-defined core genes supported divergence of the East Asian lineage from the European lineage ancestor, and then from the Amerind lineage ancestor. Greater divergence was observed in the genes of outer membrane proteins and lipopolysaccharide synthesis. Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue lymphomas. CXCL13 was highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients. CXCL13 neutralization interfered with the formation of gastric lymphoid follicles.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Interferon-γ-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection.2015
Author(s)
Yang L, Yamamoto K, Nishiumi S, Nakamura M, Matsui H, Takahashi S, Dohi T, Okada T, Kakimoto K, Hoshi N, Yoshida M, Azuma T.
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Journal Title
Mucosal Immunol
Volume: 8
Issue: 2
Pages: 279-295
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection.2014
Author(s)
Yamamoto K, Nishiumi S, Yang L, Klimatcheva E, Pandina T, Takahashi S, Matsui H, Nakamura M, Zauderer M, Yoshida M, Azuma T.
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Journal Title
Mucosal Immunol.
Volume: -
Issue: 5
Pages: 1244-1254
DOI
Related Report
Peer Reviewed
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