International research project studying common cystatin C GFR estimating equation for Asian subjects
Project/Area Number |
25305029
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Kidney internal medicine
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Research Institution | Osaka University |
Principal Investigator |
Horio Masaru 大阪大学, 医学(系)研究科(研究院), 准教授 (20273633)
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Co-Investigator(Kenkyū-buntansha) |
安田 宜成 名古屋大学, 医学(系)研究科(研究院), 准教授 (60432259)
高原 史郎 大阪大学, 医学(系)研究科(研究院), 教授 (70179547)
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Research Collaborator |
Lee Ho Yung
Kim Yon SU
Chen Hung-Chun
Tungsanga Krinag
Jha Vivekhand
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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Keywords | GFR推算式 / アジア人 / シスタチンC / クレアチニン / 国際情報交換 / シスタチンC / 国際研究者交流(インド) / 国際情報交換(韓国、タイ、インド、台湾) / 腎移植ドナー / 国際情報交換(韓国、タイ、シンガポール、台湾) |
Outline of Final Research Achievements |
Glomerular filtration rate (GFR) estimating equations are generally used for assessment of kidney function that is important for diagnosis of kidney disease. GFR equations based on serum creatinine and cystatin C developed from Japanese subjects are commonly used in Japan. But, it is not clear that the GFR equations for Japanese subjects could be used in other Asian populations. Therefore, we studied with Taiwan, Korea, Thai and India researchers and collected 273, 277, 28 and 130 measured GFR data, respectively. We analyzed the accuracy of the Japanese GFR equations in these Asian populations. Performance of the GFR equation based on serum creatinine varied according to race. The equation underestimated and overestimated GFR in Taiwan and Indian subjects, respectively. On the other hand, the GFR equation based on serum cystatin C showed better performance and acceptable accuracy in the Asian populations. It could be used as a single common GFR equation fit for Asians.
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Report
(5 results)
Research Products
(44 results)
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[Journal Article] Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy2016
Author(s)
Kimura K, Morita H, Daimon M, Horio M, Kawata T, Nakao T, Hirokawa M, Kitao R, Watanabe D, Komori T, Nagata T, Takeda S, Komaki H, Segawa K, Nakajima T, Takenaka K, Komuro I
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Journal Title
International Heart Journal
Volume: 57
Issue: 3
Pages: 386-388
DOI
NAID
ISSN
1349-2365, 1349-3299
Related Report
Peer Reviewed / Open Access
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[Journal Article] Is the new GFR equation using inulin clearance a more accurate method for Asian patients?2015
Author(s)
Kim BS, Lee YK, Choi HY, Choi SO, Shin SK, Ha SK, Lee KW, Kim YW, Kim YL, Yasuda Y, Imai E, Horio M, Tomino Y, Matsuo S, Lee HY.
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Journal Title
Clin Nephrol.
Volume: 84
Issue: 12
Pages: 331-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Renal function evaluation in patients with cancer who were scheduled to receive carboplatin or S-1.2015
Author(s)
Shibata K, Yasuda Y, Kobayashi R, Ando Y, Shimokata T, Kamiya H, Hayashi M, Maruyama S, Matsuo S, Nakao M, Tsuchiya T, Teramachi H.
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Journal Title
Clin Exp Nephrol
Volume: 19
Issue: 6
Pages: 1107-13
DOI
Related Report
Peer Reviewed
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[Journal Article] Generation of a new cystatin C-based estimating equation for glomerular filtration rate by use of 7 assays standardized to the international calibrator.2014
Author(s)
Grubb A, Horio M, Hansson LO, Björk J, Nyman U, Flodin M, Larsson A, Bökenkamp A, Yasuda Y, Blufpand H, Lindström V, Zegers I, Althaus H, Blirup-Jensen S, Itoh Y, Sjöström P, Nordin G, Christensson A, Klima H, Sunde K, Hjort-Christensen P, Armbruster D, Ferrero C.
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Journal Title
Clin Chem
Volume: 60
Issue: 7
Pages: 974-986
DOI
Related Report
Peer Reviewed
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[Journal Article] Vitamin D deficiency predicts decline in kidney allograft function: a prospective cohort study.2014
Author(s)
Obi Y, Hamano T, Ichimaru N, Tomida K, Matsui I, Fujii N, Okumi M, Kaimori JY, Yazawa K, Kokado Y, Nonomura N, Rakugi H, Takahara S, Isaka Y, Tsubakihara Y.
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Journal Title
J Clin Endocrinol Metab.
Volume: 99
Issue: 2
Pages: 527-535
DOI
Related Report
Peer Reviewed
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[Journal Article] Non-invasive magnetic resonance imaging in rats for prediction of the fate of grafted kidneys from cardiac death donors.2013
Author(s)
Kaimori JY, Iwai S, Hatanaka M, Teratani T, Obi Y, Tsuda H, Isaka Y, Yokawa T, Kuroda K, Ichimaru N, Okumi M, Yazawa K, Rakugi H, Nonomura N, Takahara S, Kobayashi E.
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Journal Title
PLoS One
Volume: 8
Issue: 5
Pages: e63573-e63573
DOI
NAID
Related Report
Peer Reviewed
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