Exploration of risk factors in heart failure by network analysis

• Project/Area Number: 25330032
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Statistical science
• Research Institution: Tohoku University
• Principal Investigator: Miyata Satoshi 東北大学, 医学(系)研究科(研究院), 准教授 (60360343)
• Co-Investigator(Kenkyū-buntansha): SAKATA Yasuhiko 東北大学, 大学院医学系研究科, 准教授 (90379206)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: コホート研究 / ネットワーク解析 / 構造方程式モデル / 慢性心不全 / アンケート調査

Outline of Final Research Achievements

Based on the clinical data from CHART-2 (Chronic Heart failure Analysis and Registry in the Tohoku district 2, 2006/10-2010/3) and the results of the questionnaire about mental stress, exercise and care prevention after the Great East Japan Earthquake (2011/3/11), we conducted network analysis for chronic heart failure (CHF) and its prognosis.
As a result of investigating relationship between the incidence of PTSD and the prognosis of heart failure patients, we found that PTSD was an independent prognosis factor of CHF.
We also studied network analysis for new appearance of heart ｆailure by SEM (structural equation modeling), and it was shown that not only undernutrition but degrees of exercise and care prevention were risk factors of heart failure via renal dysfunction, increasing BNP (brain natriuretic peptid)e and heart rate.

Research Products

• [Journal Article] Prognostic Impacts of Metabolic Syndrome in Patients With Chronic Heart Failure – A Multicenter Prospective Cohort Study – (2016)
  • Author(s): Tadaki S, Sakata Y, Miura Y, Miyata S, Asakura M, Shimada K, Yamamoto T, Fukumoto Y, Kadokami T, Yasuda S, Miura T, Ando S, Yano M, Kitakaze M, Daida H, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 80 Issue: 3 Pages: 677-688
  • DOI: 10.1253/circj.CJ-15-0942
  • NAID: 130005128464
  • ISSN: 1346-9843, 1347-4820
  • URL: https://pure.teikyo.jp/en/publications/cfb42b8c-f07d-4094-90eb-5e1ae1c2c581
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Impact of New-Onset Atrial Fibrillation in Patients With Chronic Heart Failure – A Report From the CHART-2 Study – (2016)
  • Author(s): Yamauchi T, Sakata Y, Miura M, Tadaki S, Ushigome R, Sato K, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Nochioka K, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Circulation Journal Volume: 80 Issue: 1 Pages: 157-167
  • DOI: 10.1253/circj.CJ-15-0783
  • NAID: 130005116994
  • ISSN: 1346-9843, 1347-4820
  • URL: https://pure.teikyo.jp/en/publications/8cc7c67e-b9c1-4e34-8dd1-5962c9469501
  • Peer Reviewed / Open Access
• [Journal Article] Temporal Trends in Clinical Characteristics, Management and Prognosis of Patients With Symptomatic Heart Failure in Japan – Report From the CHART Studies – (2015)
  • Author(s): Ushigome R, Sakata Y, Nochioka K, Miyata S, Miura M, Tadaki S, Yamauchi T, Sato K, Onose T, Tsuji K, Abe R, Oikawa T, Kasahara S, Takahashi J, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Circulation Journal Volume: 79 Issue: 11 Pages: 2396-2407
  • DOI: 10.1253/circj.CJ-15-0514
  • NAID: 130005104900
  • ISSN: 1346-9843, 1347-4820
  • URL: https://localhost/en/publications/01efc346-4f89-4775-bef7-3839a30da2f8
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Impact of Anemia in Patients With Chronic Heart Failure – With Special Reference to Clinical Background: Report From the CHART-2 Study – (2015)
  • Author(s): Yamauchi T, Sakata Y, Takada T, Nochioka K, Miura M, Tadaki S, Ushigome R, Sato K, Onose T, Tsuji K, Abe R, Takahashi J, Miyata S, Shimokawa H; CHART-2 investigators.
  • Journal Title: Circulation Journal Volume: 79 Issue: 9 Pages: 1984-1993
  • DOI: 10.1253/circj.CJ-15-0174
  • NAID: 130005095306
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Impact of Diabetes Mellitus in Chronic Heart Failure According to Presence of Ischemic Heart Disease – With Special Reference to Nephropathy – (2015)
  • Author(s): Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Ushigome R, Yamauchi T, Sato K, Onose T, Tsuji K, Abe R, Takahashi J, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Circulation Journal Volume: 79 Issue: 8 Pages: 1764-1772
  • DOI: 10.1253/circj.CJ-15-0096
  • NAID: 130005089372
  • ISSN: 1346-9843, 1347-4820
  • URL: https://pure.teikyo.jp/en/publications/989f95b2-5536-4a2a-9ffa-d1d58a897b78
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive Risk Stratification of Japanese Patients With Aortic Stenosis – A Proposal of a New Risk Score From the CHART-2 Study – (2015)
  • Author(s): Sato K, Sakata Y, Miura M, Tadaki S, Ushigome R, Yamauchi T, Onose T, Tsuji K, Abe R, Nochioka K, Takahashi J, Miyata S, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Circulation Journal Volume: 79 Issue: 7 Pages: 1631-1638
  • DOI: 10.1253/circj.CJ-15-0062
  • NAID: 130005083927
  • ISSN: 1346-9843, 1347-4820
  • URL: https://pure.teikyo.jp/en/publications/2cd07ef2-4b63-46ff-ae42-03a5cf1a9897
  • Peer Reviewed / Open Access
• [Journal Article] Improved Long-Term Prognosis of Dilated Cardiomyopathy With Implementation of Evidenced-Based Medication – Report From the CHART Studies – (2015)
  • Author(s): Ushigome R, Sakata Y, Nochioka K, Miyata S, Miura M, Tadaki S, Yamauchi T, Sato K, Onose T, Tsuji K, Abe R, Takahashi J, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Circulation Journal Volume: 79 Issue: 6 Pages: 1332-1341
  • DOI: 10.1253/circj.CJ-14-0939
  • NAID: 130005073161
  • ISSN: 1346-9843, 1347-4820
  • URL: https://pure.teikyo.jp/en/publications/8f22df05-30f3-4315-984c-9575ab22cc6e
  • Peer Reviewed / Open Access
• [Journal Article] Predictors and Prognostic Impact of Post-Traumatic Stress Disorder After the Great East Japan Earthquake in Patients With Cardiovascular Disease (2015)
  • Author(s): Takeo Onose, Kotaro Nochioka, Yasuhiko Sakata, Masanobu Miura, Soichiro Tadaki, Ryoichi Ushigome, Takeshi Yamauchi, Kenjiro Sato, Kanako Tsuji, Ruri Abe, Satoshi Miyata, Jun Takahashi, Hiroaki Shimokawa, on behalf of the CHART-2 Investigators
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 664-667
  • DOI: 10.1253/circj.CJ-14-1403
  • NAID: 130004927110
  • ISSN: 1346-9843, 1347-4820
  • URL: https://localhost/en/publications/e89782ed-2920-46a3-a2a9-df845cd9a7b4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prognostic Impact of Statin Use in Patients With Heart Failure and Preserved Ejection Fraction (2015)
  • Author(s): Nochioka K, Sakata Y, Miyata S, Miura M, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H; CHART-2 Investigators’.
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 574-582
  • DOI: 10.1253/circj.CJ-14-0865
  • NAID: 130004927093
  • ISSN: 1346-9843, 1347-4820
  • URL: https://pure.teikyo.jp/en/publications/3f1a506a-eee5-4b6b-b098-ed2628164928
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impacts of additive use of olmesartan in hypertensive patients with chronic heart failure: the supplemental benefit of an angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial (2015)
  • Author(s): Sakata Y, Shiba N, Takahashi J, Miyata S, Nochioka K, Miura M, Takada T, Saga C, Shinozaki T, Sugi M, Nakagawa M, Sekiguchi N, Komaru T, Kato A, Fukuchi M, Nozaki E, Hiramoto T, Inoue K, Goto T, Ohe M, Tamaki K, Ibayashi S, Ishide N, Maruyama Y, Tsuji I, Shimokawa H; on Behalf of the SUPPORT Trial Investigators.
  • Journal Title: Europian Heart Journal Volume: Epub ahead of print Issue: 15 Pages: 1-10
  • DOI: 10.1093/eurheartj/ehu504
  • Peer Reviewed / Open Access
• [Journal Article] Current Status of Primary Prevention of Sudden Cardiac Death With Implantable Cardioverter Defibrillator in Patients With Chronic Heart Failure (2015)
  • Author(s): Satake H, Fukuda K, Sakata Y, Miyata S, Nakano M, Kondo M, Hasebe Y, Segawa M, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Circulation Journal Volume: 79 Issue: 2 Pages: 381-390
  • DOI: 10.1253/circj.CJ-14-0925
  • NAID: 130004704041
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of chronic nitrate therapy in patients with vasospastic angina: multicentre registry study of the Japanese coronary spasm association. (2015)
  • Author(s): Takahashi J, Nihei T, Takagi Y, Miyata S, Odaka Y, Tsunoda R, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Momomura S, Yasuda S, Ogawa H, Shimokawa H; Japanese Coronary Spasm Association.
  • Journal Title: Europian Heart Journal Volume: 36(4): Issue: 4 Pages: 228-37
  • DOI: 10.1093/eurheartj/ehu313
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of subclinical microalbuminuria in patients with chronic heart failure. (2014)
  • Author(s): Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H; CHART-2 Investigators.
  • Journal Title: Circulation Journal Volume: 78(12) Pages: 2890-8
  • Peer Reviewed / Open Access
• [Journal Article] Extracorporeal low-energy shock-wave therapy exerts anti-inflammatory effects in a rat model of acute myocardial infarction. (2014)
  • Author(s): Abe Y, Ito K, Hao K, Shindo T, Ogata T, Kagaya Y, Kurosawa R, Nishimiya K, Satoh K, Miyata S, Kawakami K, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 78(12) Pages: 2915-25
  • NAID: 130004693854
  • Peer Reviewed / Open Access
• [Journal Article] Factors influencing the occurrence of cardiopulmonary arrest in the Great East Japan Earthquake disaster. (2014)
  • Author(s): Hao K, Takahashi J, Aoki T, Miyata S, Ito K, Sakata Y, Shimokawa H.
  • Journal Title: International Journal of Cardiology Volume: 177(2) Issue: 2 Pages: 569-72
  • DOI: 10.1016/j.ijcard.2014.08.127
  • Peer Reviewed / Open Access
• [Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension (2014)
  • Author(s): Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 34 Issue: 11 Pages: 2486
  • DOI: 10.1161/atvbaha.114.304404
  • URL: https://pure.teikyo.jp/en/publications/1cd583b9-53c8-43fb-9623-40a38c842780
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation (2014)
  • Author(s): Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Nochioka K, Tatebe S, Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Minami T, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
  • Journal Title: Circ Res. Volume: 115 Issue: 8 Pages: 738
  • DOI: 10.1161/circresaha.115.304563
  • URL: https://pure.teikyo.jp/en/publications/e90bf195-816e-43b9-b666-f1f2f5351b17
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prevalence, predictors and prognosis of patients with heart failure requiring nursing care. (2014)
  • Author(s): Miura M, Sakata Y, Nochioka K, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Miyata S, Shiba N, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 78(9) Pages: 2276-83
  • Peer Reviewed / Open Access
• [Journal Article] Gender Differences in Clinical Characteristics, Treatment and Long-Term Outcome in Patients With Stage C/D Heart Failure in Japan (2014)
  • Author(s): Sakata, Y, Miyata S, Nochioka K, Miura M, Takada T, Tadaki S, Takahashi J, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 78 Issue: 2 Pages: 428-435
  • DOI: 10.1253/circj.CJ-13-1009
  • NAID: 130003382230
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Prognostic Impact of Blood Urea Nitrogen Changes During Hospitalization in Patients With Acute Heart Failure Syndrome (2013)
  • Author(s): Miura M, Sakata Y, Nochioka K, Takahashi J, Takada T, Miyata S, Hiramoto T, Inoue K, Tamaki K, Shiba N, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 77 Issue: 5 Pages: 1221-1228
  • DOI: 10.1253/circj.CJ-12-1390
  • NAID: 10031151384
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Supplemental benefit of an angiotensin receptor blocker in hypertensive patients with stable heart failure using olmesartan (SUPPORT) trial-Rationale and design (2013)
  • Author(s): Sakata Y, Nochioka K, Miura M, Takada T, Tadaki S, Miyata S, Shiba N, Shimokawa H
  • Journal Title: Journal of Cardiology Volume: 62 Issue: 1 Pages: 31
  • DOI: 10.1016/j.jjcc.2013.02.011
  • URL: https://pure.teikyo.jp/en/publications/e1419d39-37d6-4ba1-978b-56298c24669a
  • Peer Reviewed
• [Journal Article] Prognostic Impact of Nutritional Status in Asymptomatic Patients With Cardiac Diseases (2013)
  • Author(s): Nochioka K, Sakata Y, Takahashi J, Miyata S, Miura M, Takada T, Fukumoto Y, Shiba N, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 77 Issue: 9 Pages: 2318-2326
  • DOI: 10.1253/circj.CJ-13-0127
  • NAID: 10031191760
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Usefulness of Combined Risk Stratification With Heart Rate and Systolic Blood Pressure in the Management of Chronic Heart Failure (2013)
  • Author(s): Miura, M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Takahashi J, Shiba N, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 77 Issue: 12 Pages: 2954-2962
  • DOI: 10.1253/circj.CJ-13-0725
  • NAID: 10031203581
  • ISSN: 1346-9843, 1347-4820
  • URL: https://pure.teikyo.jp/en/publications/1ddfb476-9de9-4844-86fb-12612d362548
  • Peer Reviewed
• [Journal Article] Impact of Physical Activity on Cardiovascular Events in Patients With Chronic Heart Failure (2013)
  • Author(s): 5. Miura Y, Fukumoto Y, Miura T, Shimada K, Asakura M, Kadokami T, Ando S, Miyata S, Sakata Y, Daida H, Matsuzaki M, Yasuda S, Kitakaze M, Shimokawa H.
  • Journal Title: Circulation Journal Volume: 77 Issue: 12 Pages: 2963-2972
  • DOI: 10.1253/circj.CJ-13-0746
  • NAID: 10031203582
  • ISSN: 1346-9843, 1347-4820
  • URL: https://pure.teikyo.jp/en/publications/5b2f7cd3-8316-4dbf-8177-9c16812a8bf5
  • Peer Reviewed
• [Journal Article] Impact of elevated heart rate on clinical outcomes in patients with heart failure with reduced and preserved ejection fraction. -A report from the CHART-2 Study- (2013)
  • Author(s): Takada T, Sakata Y, Miyata S, Takahashi J, Nochioka K, Miura M, Tadaki S, Shimokawa H.
  • Journal Title: Europian Journal of Heart Failure Volume: 16 Issue: 3 Pages: 309-16
  • DOI: 10.1002/ejhf.22
  • Peer Reviewed
• [Presentation] Impacts of Supplemental Use of Angiotensin Receptor Blocker Olmesartan in Hypertensive Patients with Heart Failure with Preserved Ejection Fraction -Subgroup Analysis of the SUPPORT Trial- (2015)
  • Author(s): Miura,M.
  • Organizer: AHA Scientific Sessions 2015
  • Place of Presentation: オーランド・アメリカ合衆国
  • Year and Date: 2015-11-07
• [Presentation] Prognostic Impacts of Metabolic Syndrome in Patients with Chronic Heart Failure -A Multicenter Prospective Cohort Study- (2015)
  • Author(s): Tadaki, S.
  • Organizer: AHA Scientific Sessions 2015
  • Place of Presentation: オーランド・アメリカ合衆国
  • Year and Date: 2015-11-07
• [Presentation] Sex Differences in Clinical Characteristics, Management and Prognosis in Patients with Heart Failure with Preserved Ejection Fraction: Insights from the CHART-2 Study (2015)
  • Author(s): Tsuji, K.
  • Organizer: AHA Scientific Sessions 2015
  • Place of Presentation: オーランド・アメリカ合衆国
  • Year and Date: 2015-11-07
• [Presentation] Clinical Profiles and Prognostic Factors in the Elderly Patients with Heart Failure in Japan - A Report from the CHART-2 Study- (2015)
  • Author(s): Satoh, K.
  • Organizer: HFSA 19th Annual Scientific Meeting 2015
  • Place of Presentation: ワシントン DC・アメリカ合衆国
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Prognostic Impacts and Temporal Changes of Post-Traumatic Stress Disorder after the Great East Japan Earthquake in Patients with Heart Failure -A Report from the CHART-2 Study- (2015)
  • Author(s): Onose, T.
  • Organizer: HFSA 19th Annual Scientific Meeting 2015
  • Place of Presentation: ワシントン DC・アメリカ合衆国
  • Year and Date: 2015-09-26
  • Int'l Joint Research
• [Presentation] Recent Trends in the Prevalence, Management and Clinical Outcomes of Patients with Symptomatic Chronic Heart Failure in Japan - A Report from the CHART Studies - (2015)
  • Author(s): Ushigome, R.
  • Organizer: ESC congress 2015
  • Place of Presentation: ロンドン・イギリス
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Prognostic impacts of new onset atrial fibrillation in patients with chronic heart failure: an interim analysis of the CHART-2 Study (2015)
  • Author(s): Yamauchi, T.
  • Organizer: ESC congress 2015
  • Place of Presentation: ロンドン・イギリス
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Impact of additive use of olmesartan in patients with chronic heart failure: The Supplemental Benefit of Angiotensin Receptor Blocker in Hypertensive Patients with Stable Heart Failure Using Olmesartan (SUPPORT) Trial. (2014)
  • Author(s): 2.Sakata Y, Nochioka K, Miura M, Takada T, Tadaki S, Miyata S, Shiba N, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Low-intensity pulsed ultrasound ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia -Potential involvement of mechanotransduction. (2014)
  • Author(s): 3.Shindo T, Ito K, Hanawa K, Aizawa K, Shiroto T, Ogata T, Nishimiya K, Hasebe Y, Tsuburaya R, Miyata S, Hasegawa H, Yasuda S, Kanai H, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Emerging prognostic factors in patients with aortic stenosis -A report from the CHART-2 Study- (2014)
  • Author(s): 4.Sato K, Sakata Y, Nochioka K, Miyata S, Miura M, Tadaki S, Ushigome R, Yamauchi T, Onose T, Tsuji K, Abe R, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Factors influencing the occurrence of cardiopulmonary arrest in the Great East Japan Earthquake Disaster. (2014)
  • Author(s): 5.Hao K, Takahashi J, Aoki T, Miyata S, Nihei T, Nishimiya S, Tsuburaya R, Matsumoto Y, Ito K, Sakata Y, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Sex differences in clinical characteristics and outcomes of patients with heart failure with preserved ejection fraction -A report from the CHART-2 Study. (2014)
  • Author(s): 9.Tsuji K, Sakata Y, Miura M, Miyata S, Nochioka K, Tadaki S, Ushigome R, Yamauchi T, Sato T, Onose T, Abe R, Takahashi J, Shimokawa H
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Cyclophilin a and basigin promotes pulmonary hypertension by inducing inflammation and vascular smooth muscle cell proliferation. (2014)
  • Author(s): 17.Satoh K, Suzuki K, Omura J, Kikuchi N, Miyata S, Minami T, Sugimura K, Aoki T, Nochioka K, Tatebe S, Miura M, Yamamoto S, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Recent trend in clinical characteristics, management and prognosis of patients with dilated cardiomyopathy in Japan --A report from the CHART Studies- (2014)
  • Author(s): 22.Ushigome R, Sakata Y, Nochioka K, Miyata S, Miura M, Tadaki S, Yanauchi T, Takahashi J, Shimokawa H.
  • Organizer: 18th Annual Scientific Assembly of Heart Failure Society of America
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Prognsotic impact of statin use in patients with heart failure with preserved ejection frcation --A report from the CHART-2 Study- (2014)
  • Author(s): 23.Nochioka K, Sakata Y, Miyata S, Takada T, Tadaki S, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H
  • Organizer: 18th Annual Scientific Assembly of Heart Failure Society of America
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2014-09-14 – 2014-09-17
• [Presentation] Predictors for the transition to de novo heart failure in sytage B asymptomatic patients --A report from the CHART-2 Study- (2014)
  • Author(s): 29.Takada T, Sakata Y, Miyata S, Takahashi J, Nochioka K, Miura M, Tadaki S, Ushigome R, Yamauchi T, Shimokawa H
  • Organizer: European Society Congress 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Factors influencing the occurrence of cardiopulmonary arrest in the Great East Japan earthquake Disaster. (2014)
  • Author(s): 32.Hao K, Takahashi J, Aoki T, Miyata S, Tsuburaya R, Matsumoto Y, Ito K, Sakata Y, Shimokawa H.
  • Organizer: European Society Congress 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Comparison of the prognostic impact of diabetes mellitus between ischemic and non-ishemic heart failure --A report from the CHART-2 Study- (2014)
  • Author(s): 33.Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki R, Ushigome R, Yamauchi T, Takahashi J, Shimokawa H.
  • Organizer: European Society Congress 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Crucial role of Rho-kinase in pressure-overload-induced right ventricular hypertrophy and dysfunction in mice -A possible novel therapeutic target of right ventricular failure- (2014)
  • Author(s): 40.Ikeda S, Satoh K, Kikuchi N, Miyata S, Suzuki K, Omura J, Shimizu T, Fukumoto Y, Sakata Y, Shimokawa H.
  • Organizer: Scientific Session 2014 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2014-05-01 – 2014-05-04
• [Presentation] Basigin promotes vascular smooth muscle proliferation and pulmonary hypertension. (2014)
  • Author(s): 41.Satoh K, Suzuki K, Omura J, Kikuchi N, Miyata S, Minami T, Sugimura K, Aoki T, Nochioka K, Tatebe T, Miura M, Yamamoto S, Shimizu T, Yaoita N, Fukumoto Y, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
  • Organizer: Scientific Session 2014 of the Arteriosclerosis, Thrombosis and Vascular Biology Council
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2014-05-01 – 2014-05-04
• [Presentation] Different impact of elevated heart rate on cardiovascular events between heart failure with reduced ejection fraction and preserved ejection fraction –A report from the CHART-2 Study- (2013)
  • Author(s): Takada T, Sakata Y, Miyata S, Takahashi J, Nochioka K, Miura M, Tadaki S, Shimokawa H.
  • Organizer: European Society of Cardiology 2013
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Prognostic impact of subclinical microalbuminuria in patients with chronic heart failure. (2013)
  • Author(s): Miura M, Sakata Y, Miyata S, Nochioka K, Tatebe S, Tadaki S, Takahashi J, Shiba N, Shimokawa H.
  • Organizer: European Society of Cardiology 2013
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Mortality risk stratification according to combined heart rate and systolic blood pressure in patients with chronic heart failure –A report from the CHART-2 Study- (2013)
  • Author(s): Miura M, Sakata Y, Miyata S, Nochioka K, Takada T, Tadaki S, Takahashi J, Shiba N, Shimokawa H.
  • Organizer: European Society of Cardiology 2013
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Factors influencing transition to symptomatic heart failure in Stage-B asymptomatic patients –A report from the CHART-2 Study- (2013)
  • Author(s): Takada T, Sakata Y, Miyata S, Takahashi J, Nochioka K, Miura M, Tadaki S, Shimokawa H.
  • Organizer: European Society of Cardiology 2013
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] Subclinical microalbuminuria is associated with poor prognosis in patients with chronic heart failure with preserved renal function -A Report from the CHART-2 Study- (2013)
  • Author(s): Miura M, Sakata Y, Miyata S,Nochioka K, Takada T, Tadaki S, Takahashi J, Shiba N, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Dallas, USA
• [Presentation] Statin use is associated with reduced mortality in patients with heart failure with preserved ejection fraction -A report from the CHART-2 Study- (2013)
  • Author(s): Nochioka K, Sakata Y, Miyata S, Takahashi J, Miura M, Takada T, Tadaki S, Ushigome R, Shimokawa H.
  • Organizer: American Heart Association (AHA) Scientific Sessions
  • Place of Presentation: Dallas, USA