| Project/Area Number |
25330042
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Statistical science
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Fukumoto Mariko 北里大学, 薬学部, 准教授 (40137914)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
|---|
| Keywords | 血中濃度曲線下面積 / 薬物動態解析 / ブスルファン / ブートストラップ法 / テーラメード治療 / テーラーメード治療 / 患者内誤差 / モンテカルロシミュレーション / 薬物動態 / 統計解析 |
|---|
| Outline of Final Research Achievements |
To reduce the number of blood samples necessary to estimate the optimal dose of drugs, various kinds of limited sampling strategies (LSSs) have been proposed. However, the conditions under which LSSs succeed or fail in intravenous infusion were not clarified. We investigated the accuracy and precision of existing LSSs numerically, and clalified when a LSS succeeds or fails. Consequently, we developed a new LSS for the estimation and proved that it provides an accurate and precise estimation of the optimal dose.
|
