| Project/Area Number |
25330054
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Statistical science
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
USHIJIMA Masaru 公益財団法人がん研究会, ゲノムセンター, 研究員 (60328565)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUURA Masaaki 帝京大学, 大学院公衆衛生学研究科, 教授 (40173794)
MIKI Yoshio 東京医科歯科大学, 難治疾患研究所, 教授 (10281594)
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| Research Collaborator |
DAN Shingo がん研究会, がん化学療法センター, 副部長 (70332202)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 多重検定 / SNP / ゲノムワイド関連解析 / 遺伝子間相互作用 / マイクロアレイ / クラスタリング / 遺伝子発現解析 / SNP解析 / 多重検定法 / False Discovery Rate |
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| Outline of Final Research Achievements |
We developed a statistical method for detecting gene-gene interactions using simple statistics from genome-wide SNP data. This program is about 20 times faster than the program we developed previously. In addition, we developed analytical programs which detect gene-gene interactions from microarray data and three-way interactions from SNP data in the similar way. As an application of our method, we performed Lasso clustering to the breast cancer microarray data to detect a novel subtype and related genes.
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