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Integrative neuroscience approach to neuro-dynamical mechanisms of disconnection syndrome

Research Project

Project/Area Number 25330301
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Soft computing
Research InstitutionNational Center of Neurology and Psychiatry (2015-2017)
The Institute of Physical and Chemical Research (2013-2014)

Principal Investigator

Yamashita Yuichi  国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第七部, 室長 (40584131)

Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords神経回路モデル / 認知ロボティクス / 計算論的精神医学 / 統合失調症 / 自閉スペクトラム障害 / 自閉スペクトラム症 / 自閉症スペクトラム / 脳・神経 / 神経科学 / 認知科学 / ニューラルネットワーク / 機能的断裂症候群 / 精神疾患
Outline of Final Research Achievements

In this research project, an aberrant sensory precision account, which is one of the normative theories of psychiatric disorders, was tested utilizing a recurrent neural network model. In particular, we focused on the effects of changes in estimated sensory precision on adaptive behavior via prediction error minimization mechanisms. To distinguish dysfunction at behavioral and network level, we employed a humanoid robot driven by the neural network and observed ball-playing interactions with a human experimenter.
The experimental results demonstrated that both increased and decreased sensory precision induced abnormal behaviors such as freezing and repetitive behaviors. These results may provide a system level explanation of different types of behavioral abnormality in psychiatric diseases.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (32 results)

All 2017 2016 2015 2014 2013

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Presentation (23 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] A Theoretical Framework for Evaluating Psychiatric Research Strategies2017

    • Author(s)
      Katahira Kentaro, Yamashita Yuichi
    • Journal Title

      Computational Psychiatry

      Volume: 1 Issue: 0 Pages: 184-207

    • DOI

      10.1162/cpsy_a_00008

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A prototype model for evaluating psychiatric research strategies: Diagnostic category-based approaches vs. the RDoC approach2016

    • Author(s)
      Kentaro Katahira, Yuichi Yamashita
    • Journal Title

      arXiv

      Volume: arXiv:1609.00243

    • Related Report
      2016 Research-status Report
    • Open Access
  • [Journal Article] Context sensitivity in the detection of changes in facial emotion2016

    • Author(s)
      2.Yamashita Y, Fujimura T, Katahira K, Honda M, Okada M, and Okanoya K
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 27798-27798

    • DOI

      10.1038/srep27798

    • URL

      https://pure.teikyo.jp/en/publications/e33d5696-76ea-418f-b01c-e3bbefe67228

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Learning to Perceive the World as Probabilistic or Deterministic via Interaction with Others: A Neuro-Robotics Experiment2016

    • Author(s)
      Shingo Murata, Yuichi Yamashita, Hiroaki Arie, Tetsuya Ogata, Shigeki Sugano, Jun Tani
    • Journal Title

      IEEE Transactions on Neural Networks and Learning Systems

      Volume: in press Issue: 4 Pages: 1-19

    • DOI

      10.1109/tnnls.2015.2492140

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modulation of emotional category induced by temporal factors in emotion recognition2015

    • Author(s)
      Maeshima H, Yamashita Y, Fujimura T, Okada M, Okanoya K
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 7 Pages: e0131636-e0131636

    • DOI

      10.1371/journal.pone.0131636

    • URL

      https://pure.teikyo.jp/en/publications/e390e955-ea74-4413-9238-4ce3a5b5c37b

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 精神医学研究の新潮流 Computational Psychiatry 20132014

    • Author(s)
      山下祐一
    • Journal Title

      精神医学

      Volume: 56 Pages: 270-271

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 計算論的精神医学の可能性:適応行動の代償としての統合失調症2013

    • Author(s)
      山下祐一、松岡洋夫、谷淳
    • Journal Title

      精神医学

      Volume: 55 Pages: 885-895

    • NAID

      40019788874

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 感情の認知と遷移2013

    • Author(s)
      藤村友美、中谷裕教、山下祐一
    • Journal Title

      生物の科学 遺伝

      Volume: 67 Pages: 662-667

    • Related Report
      2013 Research-status Report
  • [Presentation] スマートフォンの利用ログの特徴量設計による不安度の予測2017

    • Author(s)
      伊藤拓、深澤佑介、沖村宰、山下祐一、前田貴記、太田順
    • Organizer
      情報処理学会第82回モバイルコンピューティングとパーベイシブシステム研究会
    • Place of Presentation
      東京
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 3次元畳み込みを用いた深層学習による安静時機能的MRIの空間的次元圧縮2017

    • Author(s)
      中條 亨一,髙橋真麻,村田真悟,山下祐一,尾形哲也
    • Organizer
      第19回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Reduced Behavioral Flexibility by Aberrant Sensory Precision in Autism Spectrum Disorder: A Neurorobotics Experiment.2017

    • Author(s)
      Idei H, Murata S, Chen Y, Yamashita Y, Tani J and Ogata T
    • Organizer
      The 7th joint IEEE International Conference on Development and Learning (ICDL) and the International Conference on Epigenetic Robotics (EpiRob)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A computational approach to a linkage between the aberrant sense of agency and delayed prediction signal in schizophrenia.2017

    • Author(s)
      Yamashita Y, Okimura T, Mimura M, Maeda T
    • Organizer
      WPA World Congress of Psychiatry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Induced by Reduced Heterogeneity of Intrinsic Neuronal Excitability: A Neurorobotics Study.2017

    • Author(s)
      Idei H, Murata S, Yamashita Y and Ogata T
    • Organizer
      WPA World Congress of Psychiatry
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳の計算理論と先端情報技術に基づく感性的知覚・認知体験の共有2017

    • Author(s)
      山下祐一
    • Organizer
      19回 日本感性工学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 認知(障害)原理を検証する神経回路モデルの開発と評価2017

    • Author(s)
      山下祐一
    • Organizer
      日本発達神経科学学会第6回学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 不確実性の推定異常がもたらす固執的行動生成と切り替えの困難さ -認知ロボット実験-2016

    • Author(s)
      出井勇人, 村田真悟, Yiwen Chen, 山下祐一, 谷淳, 尾形哲也
    • Organizer
      発達神経科学学会 第5回大会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluating Number of Days Needed to Predict Anxiety by Using Smartphone.2016

    • Author(s)
      Taku Ito, Yusuke Fukazawa, Takaki Maeda, Yuichi Yamashita, Tsukasa Okimura, Jun Ota
    • Organizer
      The Ninth International Conference on Mobile Computing and Ubiquitous Networking
    • Place of Presentation
      Kaiserslautern, Germany
    • Year and Date
      2016-10-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] スマートフォンのセンサログとアプリ履歴を用いた不安度の予測2016

    • Author(s)
      伊藤 拓, 深澤 佑介, 沖村 宰, 山下 祐一, 前田 貴記, 太田 順
    • Organizer
      情報処理学会 モバイルコンピューティングとユビキタス通信研究会
    • Place of Presentation
      沖縄
    • Related Report
      2016 Research-status Report
  • [Presentation] Bayesian model of the Sense of Agency in Normal Subjects2015

    • Author(s)
      Shiro Yano, Toshiyuki Kondo, Yuichi Yamashita, Tsukasa Okimura, Hiroshi Imamizu, Takaki Maeda
    • Organizer
      International Symposium on Micro-NanoMechatronics and Human Science
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2015-11-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 予測誤差最小化原理に基づくポストディクションの構成論的理解2015

    • Author(s)
      村田真悟,山下祐一,有江浩明,尾形哲也,谷淳,菅野重樹
    • Organizer
      発達神経科学学会 第4回大会
    • Place of Presentation
      大阪
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
  • [Presentation] Direct current stimulation of bilateral Inferior Frontal region induces the modulation of facial expression recognition.2015

    • Author(s)
      Hiroaki Maeshima,Yuichi Yamashita,Kazuo Okanoya
    • Organizer
      Neuroscience2015
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Neuro-dynamical accounts for postdiction2015

    • Author(s)
      Shingo Murata, Yuichi Yamashita, Hiroaki Arie, Tetsuya Ogata, Jun Tani, Shigeki Sugano
    • Organizer
      19th Annual Meeting of the ASSC
    • Place of Presentation
      Paris, France
    • Year and Date
      2015-07-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Involvement of bilateral inferior frontal gyri in emotional recognition with social context: a TMS study.2014

    • Author(s)
      Yamashita Y, Maeshima H, Abe M, Honda M, Okada M and Okanoya K
    • Organizer
      44th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Walter E. Washington Convention Center, Washigton, DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Generation of Sensory Reflex Behavior versus Intentional Proactive Behavior in Robot Learning of Cooperative Interactions with Others.2014

    • Author(s)
      Murata S, Yamashita Y, Arie H, Ogata T, Tani J
    • Organizer
      ICDL-EPIROB 2014
    • Place of Presentation
      Palazzo Ducale, Genoa, Italy
    • Year and Date
      2014-10-13 – 2014-10-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Functional localization of Broca’s area using speech arrest induced by low intensity repetitive transcranial magnetic stimulation.2014

    • Author(s)
      Yamashita Y, Maeshima M, Abe M, Honda M, Okada M and Okanoya K
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Modulation of emotional category in facial expressions:a transcranial direct current stimulation (tDCS) study.2014

    • Author(s)
      Maeshima, H., Yamashita, Y., Okanoya, K
    • Organizer
      International symposium of adolescent brain & mind and self-regulation
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 異なる神経メカニズムによる能動的・受動的行動の選択2014

    • Author(s)
      村田真悟,山下祐一,有江浩明,尾形哲也,谷淳,菅野重樹
    • Organizer
      日本機械学会ロボティクス・メカトロニクス講演会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2014-05-25 – 2014-05-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 予測精度の予測に基づいた能動的・受動的な適応行動の生成学習2014

    • Author(s)
      村田真悟,山下祐一,有江浩明,尾形哲也,谷淳,菅野重樹
    • Organizer
      人工知能学会全国大会2014
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-05-12 – 2014-05-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Prediction error disequilibrium in schizophrenia2013

    • Author(s)
      Yuichi Yamashita, Ryosuke Izawa, Jun Tani
    • Organizer
      International Congress of Schizophrenia Research
    • Place of Presentation
      Orlando, USA.
    • Related Report
      2013 Research-status Report
  • [Presentation] Suicide attempt correlate with delusional content in the first episode of schizophrenia.2013

    • Author(s)
      Jun Matsuoka, Yuichi Yamashita, M Baba, E Funada, M Suyama, M Itokawa, R Izawa
    • Organizer
      International Congress of Schizophrenia Research
    • Place of Presentation
      Orlando, USA.
    • Related Report
      2013 Research-status Report
  • [Presentation] Altered prediction of uncertainty induced by network disequilibrium: a neuro-robotics study.2013

    • Author(s)
      Shingo Murata, Yuichi Yamashita, Tetsuya Ogata, Hiroaki Arie, Jun Tani, and Shigeki Sugano
    • Organizer
      Computational Psychiatry 2013.
    • Place of Presentation
      Miami, USA.
    • Related Report
      2013 Research-status Report
  • [Book] Self-organized functional hierarchy through multiple timescale:neuro-dynamical accounts for behavioral compositionality. in Computational and Robotic Models of the Hierarchical Organization of Behavior.2013

    • Author(s)
      Yamashita Y, Tani J.
    • Total Pages
      15
    • Publisher
      Springer, Berlin.
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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