| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In this research project, a basic study by computer simulation and mathematical analysis was conducted to establish a novel HIV-1 therapy based on the concept of the lethal mutagenesis replacing multiple drug combination therapy. In the alternative therapy, viruses are eliminated from virus-infected individuals by depriving the infectious ability from the virus by inducing mutations in viral genes by a chemical mutagen. As a result, it clarified that at least the following two conditions must be satisfied in order to eliminate HIV from HIV-1 infected individual by the alternative therapy. Specifically, 1) the efficacy of a mutagen exceeds a certain threshold value. 2) the virus production rate of wild-type HIV is below a certain threshold. In particular, 1) is considered to be the cause of failure of Phase II clinical trial for the mutagen KP-1461.
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