| Project/Area Number |
25330339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | The University of Aizu |
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Principal Investigator |
ZHU XIN 会津大学, コンピュータ理工学部, 准教授 (70448645)
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| Co-Investigator(Kenkyū-buntansha) |
NORO Mahito 東邦大学, 医学部, 准教授 (10366495)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ICD / ventricular fibrillation / sudden cardiac death / computer simulation / S-ICD / axillary implantation / single coil / dual coil / subcutaneous ICD / myocardial damage / cardiac modeling / defibrillation threshold / CRT-D |
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| Outline of Final Research Achievements |
To reduce myocardial damage caused by implantable cardioverter-defibrillators’ (ICD) shocks and improve the prognostics, we studied the implantation site, implantation configurations, and lead types of ICD based on clinical studies and computer simulations. 1. We performed clinical experiences with newly implanting pulse generators in the left axilla (30 cases) and anterior chest (40 cases) and computer simulations, and found the axillary implantations were better than the traditional implantation in the defibrillation efficiency and myocardial damage. 2. For both the left anterior chest and axillary implantations, the dual coil lead corresponds to a higher defibrillation efficiency while the single coil lead less myocardial damage caused by ICD shocks. 3. Although a subcutaneous ICD (S-ICD) has a large defibrillation threshold, myocardial damage caused by shocks from a S-CD is similar to that from a traditional ICD. This proved the safety of S-ICD.
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