Study on the optimum implantable cardioverter-defibrillators' implantation sites and clinical effectiveness

• Project/Area Number: 25330339
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Life / Health / Medical informatics
• Research Institution: The University of Aizu
• Principal Investigator: ZHU XIN 会津大学, コンピュータ理工学部, 准教授 (70448645)
• Co-Investigator(Kenkyū-buntansha): NORO Mahito 東邦大学, 医学部, 准教授 (10366495)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ICD / ventricular fibrillation / sudden cardiac death / computer simulation / S-ICD / axillary implantation / single coil / dual coil / subcutaneous ICD / myocardial damage / cardiac modeling / defibrillation threshold / CRT-D

Outline of Final Research Achievements

To reduce myocardial damage caused by implantable cardioverter-defibrillators’ (ICD) shocks and improve the prognostics, we studied the implantation site, implantation configurations, and lead types of ICD based on clinical studies and computer simulations. 1. We performed clinical experiences with newly implanting pulse generators in the left axilla (30 cases) and anterior chest (40 cases) and computer simulations, and found the axillary implantations were better than the traditional implantation in the defibrillation efficiency and myocardial damage. 2. For both the left anterior chest and axillary implantations, the dual coil lead corresponds to a higher defibrillation efficiency while the single coil lead less myocardial damage caused by ICD shocks. 3. Although a subcutaneous ICD (S-ICD) has a large defibrillation threshold, myocardial damage caused by shocks from a S-CD is similar to that from a traditional ICD. This proved the safety of S-ICD.

Research Products

• [Journal Article] Decreased Defibrillation Threshold and Minimized Myocardial Damage With Left Axilla Implantable Cardioverter Defibrillator Implantation (2016)
  • Author(s): Mahito Noro,Xin Zhu,Yoshinari Enomoto,Yasuhiro Oikawa,Hiroyuki Tatunami,Rina Ishii,Yasutake Toyoda,Masako Asami,Naohiko Sahara,Takahito Takagi,Yuriko Narabayasi,Hikari Hashimoto,Naoshi Ito,Shingo Kujime,Tsuyoshi Sakai,Keijirou Nakamura,Takao Sakata,Haruhiko Abe,Kaoru Sugi
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 878-886
  • DOI: 10.1253/circj.CJ-15-1258
  • NAID: 130005139578
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Efficacy and Myocardial Injury With Subcutaneous Implantable Cardioverter Defibrillators – Computer Simulation of Defibrillation Shock Conduction – (2016)
  • Author(s): Mahito Noro,Xin Zhu,Yoshinari Enomoto,Masako Asami,Rina Ishii,Yasutake Toyoda,Naohiko Sahara,Takahito Takagi,Yuriko Narabayasi,Hikari Hashimoto,Naoshi Ito,Shingo Kujime,Yasuhiro Oikawa,Hiroyuki Tatunami,Tsuyoshi Sakai,Keijirou Nakamura,Takao Sakata,Kaoru Sugi
  • Journal Title: Circulation Journal Volume: 80 Issue: 1 Pages: 85-92
  • DOI: 10.1253/circj.CJ-15-0883
  • NAID: 130005117007
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Recent Progress in ICD Programming and Configurations for Reducing Inappropriate Therapy and Mortality (2015)
  • Author(s): Xin Zhu,Noro Mahito
  • Journal Title: Nanotechnology and Precision Engineering Volume: 13 Pages: 9-16
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Left axillary pacemaker generator implantation with a direct puncture of the left axillary vein (2015)
  • Author(s): Noro M, Zhu X, Takagi T, Sahara N, Hashimoto H, Ito N, Enomoto Y, Nakamura K, Kujime S, Sakai T, Sakata T, Sugi K
  • Journal Title: Pacing and Clinical Electrophysiology Volume: 38 Issue: 1 Pages: 35-41
  • DOI: 10.1111/pace.12500
  • Peer Reviewed
• [Journal Article] Evaluation of defibrillation safety and shock reduction in ICD patients with increased time to detection: The randomized SANKS study (2015)
  • Author(s): Noro M, Zhu X, Takagi T, Sahara N, Narabayashi Y, Hashimoto H, Ito N, Enomoto Y, Kujime S, Sakai T, Sakata T, Sugi K
  • Journal Title: Journal of Arrhythmia Volume: 31 Issue: 2 Pages: 94-100
  • DOI: 10.1016/j.joa.2014.08.003
  • Peer Reviewed
• [Journal Article] Load-prediction scheduling algorithm for computer simulation of electrocardiogram in hybrid environments (2015)
  • Author(s): Wen-feng Shen,Zhaokai Luo,Daming Wei,Weimin Xu,and Xin Zhu
  • Journal Title: Journal of Systems and Software Volume: 102 Pages: 182-191
  • DOI: 10.1016/j.jss.2015.01.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 植込み型除細動器作動時の伝導様式に基づく、出力抑制による心筋障害抑制の検討 (2013)
  • Author(s): 野呂眞人、朱 欣、橋本 晃、伊藤尚志、榎本善成、久次米真吾、酒井 毅、坂田隆夫、及川泰宏、村上和也、立浪宏行、杉 薫
  • Journal Title: 心臓 Volume: 45
  • NAID: 130004730863
  • Peer Reviewed
• [Presentation] 植え込み型除細動器植え込み術の術前最尤化技術 (2016)
  • Author(s): 朱 欣
  • Organizer: ふくしま発 新技術説明会
  • Place of Presentation: JST東京本部別館1Fホール
  • Year and Date: 2016-02-26
• [Presentation] 効果的なSubcutaneous Implantable Cardioverte Defibrillator（SICD）のリード及本体の留置部位の検討 (2016)
  • Author(s): 浅見雅子，野呂眞人，朱欣, 他
  • Organizer: 第8回植え込みデバイス関連冬季大会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2016-02-05
• [Presentation] 除細動閾値，心筋障害程度の検証から植込み型除細動器（ICD）におけるSingle coil leadとDual coil leadの有用性の検討 (2016)
  • Author(s): 中村啓二郎，野呂眞人，朱欣, 他
  • Organizer: 第8回植え込みデバイス関連冬季大会
  • Place of Presentation: 北九州国際会議場
  • Year and Date: 2016-02-05
• [Presentation] Study of defibrillation threshold and myocardial injury in the different ICD implantation site with Single coil and dual coil (2015)
  • Author(s): Hashimoto H, Noro M, Zhu X, et al.
  • Organizer: 第30回日本不整脈学会学術大会／第32回日本心電学会学術集会合同学術大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2015-07-28
• [Presentation] Study of impact on myocardial injury and device at the time of direct current shock in device implanted patients using computer simulation (2015)
  • Author(s): Takagi T, Noro M, Zhu X, et al.
  • Organizer: 第30回日本不整脈学会学術大会／第32回日本心電学会学術集会合同学術大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2015-07-28
• [Presentation] Subcutaneous implantable cardioverter-defibrillator(SICD)と従来の植え込み型除細動器の除細動効果と心筋障害の検討ー電気伝導様式のコンピュータシミュレーションを用いてー (2015)
  • Author(s): 榎本善成, 野呂眞人, 朱欣, 他
  • Organizer: 第35回日本ホルターノンインベンシブ心電学研究会
  • Place of Presentation: コクヨホール
  • Year and Date: 2015-06-13
• [Presentation] Subcutaneous Implantable Cardioverter-Defibrillator(SCID)の有用性の検討 (2015)
  • Author(s): 佐原尚彦,野呂眞人,朱欣,高木高人,楢林ゆり子,橋本晃,伊藤尚志,榎本善成,坂田隆夫,杉薫
  • Organizer: 第7回植込みデバイス関連冬季大会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-20
• [Presentation] Decrease defibrillation thresholds and minimize myocardial damage by implanting cardioverter-defibrillators in the left axilla (2015)
  • Author(s): Hashimoto H, Noro M, Zhu X, Takagi T, Sahara N, Narabayashi Y, Ito Y, Enomoto Y, Kujime S, Nakamura K, Sakata T, Sugi K
  • Organizer: Cardio Rhythm 2015
  • Place of Presentation: 香港
  • Year and Date: 2015-01-31
• [Presentation] Study on the defibrillation efficiency and myocardial damage of subcutaneous implantable cardioverter-defibrillators (2015)
  • Author(s): Takagi T, Noro M, Zhu X, Sahara N, Narabayashi Y, Hashimoto H, Ito N, Enomoto Y, Kujime S, Nakamura K, Sakata T, Sugi K
  • Organizer: Cardio Rhythm 2015
  • Place of Presentation: 香港
  • Year and Date: 2015-01-31
• [Presentation] Computer Simulation of Defibrillations Using Subcutaneous Implantable Cardioverter-Defibrillators (2014)
  • Author(s): Zhu X, Noro M,Sugi K
  • Organizer: IEEE iCAST 2014
  • Place of Presentation: フランス パリ
  • Year and Date: 2014-10-30
• [Presentation] Study on the computer simulation of cardiac defibrillation using subcutaneous implantable cardioverter- defibrillators:皮下埋め込み式心除細動器除細動のコンピュータシミュレーションに関する研究 (2014)
  • Author(s): 朱欣,野呂眞人,及川泰宏,村上和也,立浪宏行,高木高人,佐原尚彦,楢林ゆり子,橋本晃,酒井毅,坂田隆夫,杉薫
  • Organizer: 第30回心電情報処理ワークショップ
  • Place of Presentation: 熱海
  • Year and Date: 2014-10-26
• [Presentation] Evaluation of the late safety and efficacy of left axillary pacemaker generator implantations with a direct puncture of the left axillary vein (2014)
  • Author(s): Noro M, Zhu X, Enomoto Y, Ito N, Nakamura K, Sakai T, Hashimoto H, Oikawa Y, Murakami K, Tatunami H, Sakata T, Sugi K
  • Organizer: CARDIOSTIM 2014
  • Place of Presentation: フランス ナイス
  • Year and Date: 2014-06-18
• [Presentation] 除細動器の基礎的理論と実際 (2014)
  • Author(s): Mahito Noro, Xin Zhu, Hikaru Hashimoto, Naoshi Ito, Yoshinari Enomoto, Shingo Kujime, Tuyoshi Sakai, Yasuhiro Oikawa, Kazuya Murakami, Hiroyuki Tatunami, Takao Sakata, Kaoru Sugi
  • Organizer: 第6回植込みデバイス関連冬季大会
  • Place of Presentation: 広島国際会議場
  • Invited
• [Presentation] 当院でのDevice ( Pacemaker, ICD, CRT-D) 植込み,Pacemaker-機能、QOL, 美容的関連から,植込み型除細動器(ICD)の問題点の考察 (2013)
  • Author(s): 野呂真人
  • Organizer: 第3回Tokyo CIEDs Meeting
  • Place of Presentation: 5) 品川.東京Boston Scientific Japan 本社
  • Invited
• [Presentation] Device植込み患者の周術期の管理 (2013)
  • Author(s): 野呂真人
  • Organizer: 第34回日本循環制御医学総会
  • Place of Presentation: 福井県県民ホール
• [Presentation] How and Where to Implant the Device Depending on Case (2013)
  • Author(s): Mahito Noro, Xin Zhu, Hikaru Hashimoto, Naoshi Ito, Yoshinari Enomoto, Shingo Kujime, Tuyoshi Sakai, Takao Sakata, Kaoru Sugi
  • Organizer: The 28th Annual Meeting of The Japanese Heart Rhythm Society
  • Place of Presentation: Shintakanawa Prince Hotel
• [Presentation] Examination for the Myocardial Protection by Output Inhibition Based on the Electrical Conduction Style and Implantation Site of Generator of Implantable Cardiovarter Defibrillation (ICD) at the Shock of ICD (2013)
  • Author(s): Mahito Noro, Xin Zhu, Hikaru Hashimoto, Naoshi Ito, Yoshinari Enomoto, Shingo Kujime, Tuyoshi Sakai, Takao Sakata, Kaoru Sugi
  • Organizer: The 28th Annual Meeting of The Japanese Heart Rhythm Society
  • Place of Presentation: Shintakanawa Prince Hotel
• [Presentation] 植込み型除細動器(ICD)作動伝導様式に基づいた、ショックによる心筋障害の抑制を目的としたICD本体留置部位とリードの選択の検討 (2013)
  • Author(s): Mahito Noro, Xin Zhu, Hikaru Hashimoto, Naoshi Ito, Yoshinari Enomoto, Shingo Kujime, Tuyoshi Sakai, Takao Sakata, Kaoru Sugi
  • Organizer: 第61回心臓病学会学術集会
  • Place of Presentation: ホテル日航熊本
• [Presentation] 植込み型除細動器(ICD)作動伝導様式に基づいた、ショックによる心筋障害の抑制を目的としたICD本体留置部位とリードの選択の検討 (2013)
  • Author(s): Mahito Noro, Hikaru Hashimoto, Naoshi Ito, Yoshinari Enomoto, Shingo Kujime, Tuyoshi Sakai, Takao Sakata, Kaoru Sugi
  • Organizer: 第17回日本心不全学会学術集会
  • Place of Presentation: 大宮ソニックシティ
• [Patent(Industrial Property Rights)] 植え込み型除細動器の植え込み部位における体内電気伝導様式をシミュレーショ (2015)
  • Inventor(s): 朱 欣、野呂眞人
  • Industrial Property Rights Holder: 会津大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-11-05