Force distribution and morphological change in polarized cell migration
| Project/Area Number |
25330341
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Life / Health / Medical informatics
|
|---|
| Research Institution | Aichi Prefectural University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IKEDA Kazushi 奈良先端科学技術大学院大学, 情報科学研究科, 教授 (10262552)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IWADATE Yoshiaki 山口大学, 理学部, 准教授 (40298170)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | メカノバイオロジー / 細胞移動 / 数理モデル / Myosin II / メカノセンシング / 細胞運動 / 運動極性 / 力分布 |
|---|
| Outline of Final Research Achievements |
This research aims to elucidate the mechanism of cell migration focusing on mechanical processes, in which cell acts mechanically on the culture substrate, integrates all resultant forces to generate moving polarity, and migrates actually. To this end, we developed Bayesian method for estimating force, extracted migration property of neutrophils and Dictyostelium in mechanical stimulation, analyzed Myosin II accumulation during migration, and developed mathematical models of cell migration (Dictyostelium and keratocyte).
|
Report
(4 results)
Research Products
(5 results)
