Study on mechanisms of contrast gain control in retinal neural circuits

• Project/Area Number: 25330353
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Life / Health / Medical informatics
• Research Institution: Chukyo University
• Principal Investigator: Ishihara Akito 中京大学, 工学部, 教授 (80387620)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 網膜オフ型双極細胞 / 順応 / 数理モデル / 光応答シミュレーション / グルタミン酸レセプタ / 錐体視細胞 / 網膜OFF型双極細胞 / シナプス伝達 / シナプス / AMPA型グルタミン酸レセプタ

Outline of Final Research Achievements

The contrast gain control which is expressed by a word as light and contrast adaptation is one of the important visual information processing to smoothly transmit information of fluctuation of the brightness on a retina to central nerves systems. In this research, mathematical models from cones to bipolar cells which are the first neural circuit for the contrast gain control were constructed by ionic mechanisms based on physiological evidences. The results that analyzed by using the models suggest that neural mechanisms existing in photo-transduction of the cone photoreceptors and glutamate receptors of the off type bipolar cells will participate in contrast gain control.

Research Products

• [Journal Article] 網膜OFF型双極細胞の光応答におけるAMPA型レセプタの寄与 (2014)
  • Author(s): 石原 彰人，山中 大輔
  • Journal Title: 電子情報通信学会技術研究報告． NC，ニューロコンピューティング Volume: 113 Pages: 27-30
  • Acknowledgement Compliant
• [Presentation] Development of an on-line simulation platform for neuroscience research (2015)
  • Author(s): Ikeno H, Yamazaki T, Kamiyama Y, Ishihara A, Inagaki K, Hirata Y, Okumura Y, Kannon T, Satoh S, Wagatsuma H, Asai Y, Yamaguchi Y and Usui S
  • Organizer: Front. Neurosci. Conference Abstract: Neuroinformatics 2015
  • Place of Presentation: Australia
  • Year and Date: 2015-08-20
  • Int'l Joint Research
• [Presentation] 微小眼球運動を伴う網膜視細胞層応答の情報量評価 (2014)
  • Author(s): 稲垣圭一郎, 観音隆幸, 神山斉己, 石原彰人, 臼井支朗
  • Organizer: 電子情報通信学会ヒューマン情報処理研究会
  • Place of Presentation: 奈良
  • Year and Date: 2014-09-24 – 2014-09-25
• [Presentation] 網膜OFF型双極細胞の光応答におけるAMPA型レセプタの寄与 (2014)
  • Author(s): 石原彰人, 山中大輔
  • Organizer: 電気情報通信学会ニューロコンピューティング研究会
  • Place of Presentation: 東京都玉川