Development of simulation method of behaviors in the body based on signal transduction pathway
| Project/Area Number |
25330356
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Life / Health / Medical informatics
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| Research Institution | Okayama University of Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIMURA AKIHIKO 慶應義塾大学, 医学部, 教授 (90182815)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | リウマチ / シミュレーション / F759マウス / 炎症アンプ / IL-6 / NFkB / コンピュータシミュレーション / 滑膜細胞 / Th17 / マクロファージ |
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| Outline of Final Research Achievements |
The computer model which contains some parts of the body and simultaneously calculates intra-celluar reactions and the population of cell groups was developed by constructing a model of the rheumatoid arthritis. The model contained the inflammation amplifier of IL-6/STAT3 and IL-17/NFkB pathways in synovial cells, infiltration of macrophages and Th17 from blood vessel to joint, and the production of cytokines by infiltrated immune cells. The model mimicked the differences between wild-type mice and F759 mice. The simulation results of the model were compared with the experimental IL-6 productions by fibroblasts extracted from F759 mice. The sensitivity analysis of the model suggested that IL-6/STAT3 pathway is more important than IL-17/NFkB pathway.
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Report
(4 results)
Research Products
(7 results)
