| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Ionizing radiation increases the risks of leukemia and certain types of solid tumors. The relative risk of radiation-induced leukemia is much higher than those of solid tumors. Recently, Dr. Nakamura has hypothesized about the mechanism of radiation induced leukemia where the radiation-related acute lymphoid leukemia (ALL) risk for a population is almost entirely attributable to a small number of predisposed individuals in whom relatively large numbers of translocation-carrying pre-ALL cells have accumulated. To prove this hypothesis, we focused on BCR/ABL fusion gene which is a one of common chromosomal translocations known as Philadelphia chromosome and explored radiation induced tumorigenesis study by using BCR/ABL transgenic mice (BCR/ABLTg/- mice). Our data showed that BCR/ABLTg/- mice are susceptible to radiation-induced thymic lymphoma development.
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