| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In order to uncover the underlying mechanisms of genotoxic stress-induced biological effects, we have analyzed the cellular and molecular responses to various types of genotoxic stress in various types of cultured cell lines, including human induced pluripotent stem (hiPS) cells and p53-mutated iPS cells. As a result, we have found that iPS cells maintain their genomic stability thorough both p53-depnendent and -independent apoptotic pathways. These results provide important clues to the understanding of the mechanisms of maintaining genomic stability in multi-potent or tissue stem cells, and the improvement of the quality control of those cells.
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