Research Project
Grant-in-Aid for Scientific Research (C)
When the pregnant mice of ICR strain and C57BL strain are exposed to low dose radiation, the fetuses transiently acquire a resistance against the following high dose radiation in regards to the frequency of malformation occurrence. In order to reveal the mechanisms for this so-called radioadaptive response (RAR), in vitro-fertilized eggs from donors of RAR-proficient mouse strains (ICR or C57BL) were transplanted into the recipient (surrogate) mothers of RAR-deficient strain (C3H), and induction of RAR in the fetuses was tested. Induction of RAR in the fetuses obtained from the reversed strain combination of the donor and the recipient was also tested. As a result, we revealed that the strain-dependent RAR factor existed in the body of the recipient mother mice, and that EGF and bFGF are the components of responsible maternal factors for the strain-dependent RAR.
All 2017 2016 2015 2014 2013 Other
All Journal Article (17 results) (of which Peer Reviewed: 16 results, Open Access: 7 results, Acknowledgement Compliant: 3 results) Presentation (25 results) (of which Int'l Joint Research: 4 results, Invited: 2 results) Book (2 results) Remarks (2 results)
Journal of Radiation Research
Volume: 印刷中 Issue: 4 Pages: 421-429
10.1093/jrr/rrw133
保健物理
Volume: 印刷中
PLoS One
Volume: 11 Issue: 1 Pages: e0146730-e0146730
10.1371/journal.pone.0146730
Volume: 56 Issue: 5 Pages: 760-767
10.1093/jrr/rrv030
120006959730
Molecular Cancer
Volume: 14 Issue: 1 Pages: 1-13
10.1186/s12943-015-0429-7
Cancer Letter
Volume: 362 Issue: 2 Pages: 167-173
10.1016/j.canlet.2015.03.030
Human and Experimental Toxicology
Volume: 34 Issue: 3 Pages: 272-283
10.1177/0960327114537537
BMB Rep
Volume: 47 Pages: 575-580
J Biochem
Volume: 156 Pages: 85-95
Biochem. Biophys. Res. Commun.
Volume: 450 Issue: 4 Pages: 1498-1504
10.1016/j.bbrc.2014.07.037
Volume: 9 Issue: 8 Pages: e106277-e106277
10.1371/journal.pone.0106277
Radiation Biology Research Communications
Volume: 49 Pages: 396-409
40020314335
Isotope News
Volume: 726 Pages: 25-27
J Radiat Res
Volume: 55 Issue: 1 Pages: 84-96
10.1093/jrr/rrt096
Journal of Neuroscience Research
Volume: 92 Issue: 7 Pages: 915-926
10.1002/jnr.23363
J. Radiat. Res
Volume: 54 Issue: 4 Pages: 620-629
10.1093/jrr/rrs140
放射線科学
Volume: 56 Pages: 4-17
http://www.nirs.go.jp/index.shtml
http://www.qst.go.jp/