| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
This study was begun to extend our knowledge of the repair pathways for DNA double strand breaks (DSBs). We showed that complex DSBs efficiently activate the DNA end resection, an early step in homologous recombination (HR). It was also elucidated that human cells in the G1-phase exhibit resection activity, which requires CtIP as the activity in the S/G2-phase does. Furthermore, it was suggested that CtIP has unknown roles at the DSB sites following the initiation of resection. In addition, the signals for cell senescence and cell death were highly induced in cells following heavy ion beam-exposure, which produces complex-type DSBs.
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