Repair pathway of DNA double strand breaks in S-phase cells
Project/Area Number |
25340042
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Risk sciences of radiation and chemicals
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Research Institution | National Institutes for Quantum and Radiological Science and Technology |
Principal Investigator |
YAJIMA Hirohiko 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 人材育成センター, 主任研究員(任常) (30261895)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | DNA二本鎖切断 / DNA修復 / 相同組換え / end resection / CtIP |
Outline of Final Research Achievements |
This study was begun to extend our knowledge of the repair pathways for DNA double strand breaks (DSBs). We showed that complex DSBs efficiently activate the DNA end resection, an early step in homologous recombination (HR). It was also elucidated that human cells in the G1-phase exhibit resection activity, which requires CtIP as the activity in the S/G2-phase does. Furthermore, it was suggested that CtIP has unknown roles at the DSB sites following the initiation of resection. In addition, the signals for cell senescence and cell death were highly induced in cells following heavy ion beam-exposure, which produces complex-type DSBs.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway2016
Author(s)
Su, F., Bhattacharya, S., Abdisalaam, S., Mukherjee, S., Yajima, H., Yang, Y., Mishra, R., Srinivasan, K., Ghose, S., Chen, DJ., Yannone, SM. and Asaithamby, A.
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Journal Title
Oncotarget
Volume: 7
Issue: 1
Pages: 46-65
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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