Effect of housing conditions on neurotoxicity of chemicals
| Project/Area Number |
25340047
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Risk sciences of radiation and chemicals
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIDA ATSUHIKO 広島大学, 大学院総合科学研究科, 教授 (90212886)
ISHIHARA YASUHIRO 広島大学, 大学院総合科学研究科, 助教 (80435073)
MUKUDA TAKAO 鳥取大学, 医学部, 講師 (60346335)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 海馬 / 飼育環境 / 社会的孤独 / トリメチルスズ / ＢＤＮＦ / ニューロステロイド / 神経障害 |
|---|
| Outline of Final Research Achievements |
Wistar male rats on postnatal day 28 were divided into three groups: isolated, pair housed, and enrichment environment group. After 6 weeks socially isolated housing, hippocampal BDNF content was significantly lower than that in pair-housed rats. Housing conditions did not affected on pyramidal cell numbers in the hippocampus. Injection of trimethyltin induced decrease in pyramidal cell numbers in hippocampus, which was significantly lower in isolated and enriched environment rats than pair-housed rats. Trimethyltin injection significantly increased locomotor activity of pair-housed rats, but not affected on isolated and enriched rats after the 7 days.
Socially isolated housing condition reduced BDNF contents but not affected on the cell number in the hippocampus. Pyramidal cells in the hippocampus were more damaged in isolated rats than pair-housed after trimethyltin injection. Increase in vulnerability of hippocampus might be caused by decrease in BDNF.
|
Report
(4 results)
Research Products
(35 results)
-
-
-
-
-
-
-
-
[Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-12014
Author(s)
Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
-
Journal Title
Nature Commun
Volume: 5
Issue: 1
Pages: 3634-3634
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Involvement of brain oxidation in the cognitive impairment in a triple transgenic mouse model of Alzheimer's disease: Non-invasive measurement of the brain redox state by magnetic resonance imaging.2013
Author(s)
Ishihara Y, Itoh K, Mitsuda Y, Shimada T, Kubota T, Kato C, Song SY, Kobayashi Y, Mori-Yasumoto K, Sekita S, Kirino Y, Yamazaki T, Shimamoto N.
-
Journal Title
Free Radic Res.
Volume: 47
Issue: 9
Pages: 731-739
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] An active C-terminally truncated form of Ca2+/calmodulin-dependent protein kinase phosphatase-N (CaMKP-N/PPM1E).2013
Author(s)
Ishida A, Tsumura K, Oue M, Takenaka Y, Shigeri Y, Goshima N, Ishihara Y, Hirano T, Baba H, Sueyoshi N, Kameshita I, Yamazaki T.
-
Journal Title
BioMed Res. Int.
Volume: 2013
Pages: 134813-134813
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
