| Project/Area Number |
25340049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Nihon Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU RYOU 広島国際大学, 薬学部, 助教 (00570491)
FUJIMOTO NARIAKI 広島大学, 原爆放射線医科学研究所, 准教授 (40243612)
URAMARU NAOTO 日本薬科大学, 薬学部, 講師 (90424069)
SUGIHARA KAZUMI 広島国際大学, 薬学部, 教授 (20271067)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | ブロム化難燃剤 / PCB / 代謝的活性化 / 内分泌撹乱 / 甲状腺ホルモン撹乱 / 核内受容体 / 甲状腺ホルモン代謝 / 水酸化代謝物 / 甲状腺ホルモン受容体 / 内分泌撹乱作用 |
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| Outline of Final Research Achievements |
PCB and some brominated flame retardants were metabolized to their active hydroxylated metabolites which are related structures to thyroid hormone. These active metabolites activated nuclear receptors such as thyroid hormone receptor. These metabolites also inhibited thyroid hormone dependent protein function-regulating factor and thyroid hormone generating enzyme, iodotyronine deionidase. In contrast, these metabolites induced the thyroid hormone metabolizing enzymes via nuclear receptor activation.
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