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In-situ Real-Time Monitoring of Volatile Organic Compound Exposure for Patients with Multiple Chemical Sensitivity

Research Project

Project/Area Number 25340050
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Risk sciences of radiation and chemicals
Research InstitutionTokai University

Principal Investigator

SAKABE Kou  東海大学, 医学部, 教授 (70162302)

Co-Investigator(Renkei-kenkyūsha) TSUNODA Masashi  北里大学, 医学部医学科, 准教授 (00271221)
TAKANO Hirohisa  京都大学, 大学院工学研究科, 教授 (60281698)
KUNUGITA Naoki  国立保健医療科学院, 環境衛生部長 (90178020)
TATEMICHI Masayuki  東海大学, 医学部医学科, 教授 (00318263)
MATSUDA Tetsuya  玉川大学, 脳科学研究所, 教授 (30384720)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords化学物質過敏症 / 自律神経機能 / 揮発性有機化合物 / 条件づけ / 嗅覚過敏 / 心身相関 / 不安障害 / 不定愁訴 / 体動 / 活動量 / 呼気分析
Outline of Final Research Achievements

In-situ real-time monitoring of volatile organic compound (VOC) exposure and autonomic nervous function(ANSF) were conducted for eight multiple chemical sensitivity (MCS) patients. 1)VOC exposure, and ANSF seemed well related in some symptoms. Based on these characteristics, prevention measures of symptoms for each subject may be proposed. 2) We observed significant activations in the prefrontal cortex (PFC) during olfactory stimulation using several different odorants in patients with MCS by NIRS imaging. The study also included a subjective assessment of the physical and psychological status and of the perception of irritating and hedonic odors.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (26 results)

All 2015 2014 2013

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Invited: 1 results) Book (5 results)

  • [Journal Article] In-situ real time monitoring of VOC exposure and heart rate variability for patient with MCS.2015

    • Author(s)
      Atsushi Mizukoshi, Kazukiyo Kumagai, Naomichi Yamamoto, Miyuki Noguchi, Kazuhiro Yoshiuchi, Hiroaki Kumano, Kou Sakabe, Yukio Yanagisawa
    • Journal Title

      Int.J. Environ. Res. Public Health

      Volume: 12 Issue: 10 Pages: 12447-12465

    • DOI

      10.3390/ijerph121012446

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Assessment of cerebral blood flow in patient with MCS using near-infrared spectroscopy-recovery after olfactory stimulation:a case-sontrol study.2015

    • Author(s)
      Kenichi Azuma, Iwao Uchiyama, Mari Tanigawa, Ikuko Namba, Michiyo Azuma, Hirohisa Takano, Toshikazu Yoshikawa, Kou Sakabe
    • Journal Title

      Environ. Health Prev. Med.

      Volume: 20 Issue: 3 Pages: 185-194

    • DOI

      10.1007/s12199-015-0448-4

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Assessment of cerebral blood flow in patients with multiple chemical sensitivity using near-infrared spectroscopy-recovery after olfactory stimulation: a case-control study.2015

    • Author(s)
      Azuma K1, Uchiyama I, Tanigawa M, Bamba I, Azuma M, Takano H, Yoshikawa T, Sakabe K.
    • Journal Title

      Environ Health Prev Med.

      Volume: 20(2) Pages: 23-32

    • NAID

      50009568623

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure.2014

    • Author(s)
      Suyama K, Watanabe M, Sakabe K, Otomo A, Okada Y, Terayama H, Imai T, Mochida J.
    • Journal Title

      PLoS One

      Volume: 24;9(1) Issue: 1 Pages: e86951-e86951

    • DOI

      10.1371/journal.pone.0086951

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 精巣内インターロイキン-35 の役割.2014

    • Author(s)
      寺山隼人、善本隆之、内藤宗和、平井宗一、曲寧、畑山直之、林省吾、金沢輝久、隅山香織、坂部貢、伊藤正裕
    • Journal Title

      Reproductive Immunology and Biology(日本生殖免疫学会誌)

      Volume: 29(1) Pages: 13-23

    • NAID

      130005111145

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege.2014

    • Author(s)
      Terayama H, Yoshimoto T, Hirai S, Naito M, Qu N, Hatayama N, Hayashi S, Mitobe K, Furusawa J, Mizoguchi I, Kezuka T, Goto H, Suyama K, Moriyama H, Sakabe K, Itoh M.
    • Journal Title

      PLoS One.

      Volume: 23;9(4)

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] サイトカインによる精巣免疫特権の維持?IL-35の役割とその病態生理学的意義について?2014

    • Author(s)
      寺山隼人、伊藤正裕、内藤宗和、平井宗一、曲寧、畑山直之、林省吾、田村摩衣子、金沢輝久、善本隆之、坂部貢
    • Journal Title

      日本病態生理学会雑誌(Japanese Journal of Pathophysiology)

      Volume: 23 (3) Pages: 46-49

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reproductive immunology and Immnotoxicology.2014

    • Author(s)
      Hayato Terayama, Kou Sakabe
    • Journal Title

      ImmunoTox Letter

      Volume: 19(1) Pages: 11-12

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Establishment and characterization of a human lymphatic endothelial cell line.2014

    • Author(s)
      Nakamura R1, Sugano M, Sone Y, Sakabe K, Itoh T, Kiyono M.
    • Journal Title

      Biol Pharm Bull.

      Volume: 37(4) Pages: 683-7

    • NAID

      130003390958

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 化学物質過敏症-免疫学的側面から2013

    • Author(s)
      坂部 貢、寺山隼人、小島弘幸、吉田貴彦、木村穣
    • Journal Title

      アレルギーの臨床

      Volume: 446 Pages: 23-27

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 化学物質過敏症 診断と治療の最前線2015

    • Author(s)
      坂部 貢
    • Organizer
      第24回 日本臨床環境医学会学術集会
    • Place of Presentation
      北里大学白金校舎(東京都港区)
    • Year and Date
      2015-06-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 化学物質過敏症有訴者に対する匂いによる嗅覚刺激が脳血流変化に及ぼす影響‐その32015

    • Author(s)
      東賢一、内山巌雄、谷川真理、東実千代、萬羽郁子、高野裕久、吉川敏一、坂部貢
    • Organizer
      第85回 日本衛生学会学術総会
    • Place of Presentation
      和歌山県民文化会館(和歌山県和歌山市)
    • Year and Date
      2015-04-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Acetamiprid affect the various gene expressions in murine testis and brain2015

    • Author(s)
      寺山隼人、金沢輝久、田村摩衣子、古谷祐生子、遠藤整、内藤宗和、立道昌幸、渡辺哲、坂部貢
    • Organizer
      第85回日本衛生学会学術総会
    • Place of Presentation
      和歌山県民文化会館・ホテルアバローム紀の国
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Variations in the vessels connecting the posterior tributary of the left renal vein to the left ascending lumbar vein without communicating with other renal veins in a Japanese cadaver2015

    • Author(s)
      寺山隼人、易勤、小路直、田中理、金沢輝久、小瀬村典之、田村摩衣子、関口雅樹、内藤宗和、坂部貢
    • Organizer
      第120回日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] ネオ二コチノイド系アセタミプリド曝露によるマウス精巣および脳への影響2014

    • Author(s)
      寺山隼人、金沢輝久、田村摩衣子、遠藤整、坂部貢
    • Organizer
      環境ホルモン学会第17回研究発表会
    • Place of Presentation
      東京大学山上会館
    • Year and Date
      2014-12-09
    • Related Report
      2014 Research-status Report
  • [Presentation] インターロイキン-35 による精巣免疫特権の維持2014

    • Author(s)
      寺山隼人、善本隆之、内藤宗和、平井宗一、曲寧、畑山直之、林省吾、倉升三幸、水戸部佳奈、古澤純一、溝口出、毛塚剛司、後藤浩、金沢輝久、坂部貢、伊藤正裕
    • Organizer
      第92回東京医科大学・東京薬科大学免疫アレルギー研究会
    • Place of Presentation
      東京医科大学病院自主自学館
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 低用量フタル酸エステル曝露による自己免疫性精巣炎への影響2014

    • Author(s)
      寺山隼人、坂部貢、平井宗一、内藤宗和、曲寧、倉升三幸、小川夕輝、畑山直之、林省吾、古谷祐生子、金沢輝久、伊藤正裕
    • Organizer
      第21回日本免疫毒性学会学術年会
    • Place of Presentation
      徳島文理大学国際会議場
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Contribution of IL-35 to maintaining the immune privilege of testis2014

    • Author(s)
      Hayato Terayama、Masahiro Itoh、Shuichi Hirai、Munekazu Naito、Ning Qu、Maiko Tamura、Teruhisa Kanazawa、Kou Sakabe
    • Organizer
      第24回日本病態生理学会大会
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2014-08-08 – 2014-08-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 用量フタル酸エステル曝露による自己免疫性精巣炎への影響2014

    • Author(s)
      寺山隼人、坂部貢、平井宗一、内藤宗和、曲寧、倉升三幸、小川夕輝、畑山直之、林省吾、隅山香織、金沢輝久、伊藤正裕
    • Organizer
      第23回日本臨床環境医学学会学術集会
    • Place of Presentation
      京都大学百周年時計台記念館国際交流ホール
    • Year and Date
      2014-06-14 – 2014-06-15
    • Related Report
      2014 Research-status Report
  • [Presentation] 精巣のimmune privilegeにおけるインターロイキン-35の役割2014

    • Author(s)
      寺山隼人、内藤宗和、善本隆之、平井宗一、曲寧、倉升三幸、金沢輝久、隅山香織、坂部貢、伊藤正裕
    • Organizer
      日本アンドロロジー学会第33回学術大会
    • Place of Presentation
      軽井沢プリンスホテルウエスト
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Contribution of IL-35 to maintaining the testicular immune privilege2014

    • Author(s)
      Hayato Terayama、Shuichi Hirai、Takayuki Yoshimoto、Munekazu Naito、Miyuki Kuramasu、Ning Qu、Naoyuki Hatayama、Teruhisa Kanazawa、Kaori Suyama、Kou Sakabe、Masahiro Itoh
    • Organizer
      34th Annual Meeting of the American Society for Reproductive Immunology
    • Place of Presentation
      Allegria Hotel (New York)
    • Year and Date
      2014-06-02 – 2014-06-05
    • Related Report
      2014 Research-status Report
  • [Book] 免疫症候群(第2版)2015

    • Author(s)
      坂部 貢、寺山隼人、金沢輝久、木村穣ほか
    • Total Pages
      859
    • Publisher
      (株)日本臨床社
    • Related Report
      2015 Annual Research Report
  • [Book] シックハウス症候群への対策と予防2015

    • Author(s)
      坂部 貢
    • Publisher
      日本医事新報
    • Related Report
      2014 Research-status Report
  • [Book] 環境・職業性因子による疾患、最近の動向2015

    • Author(s)
      坂部 貢
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report
  • [Book] 化学物質過敏症の観客的診断に関する最近の知見2014

    • Author(s)
      坂部 貢
    • Publisher
      公益財団法人 産業医学振興財団
    • Related Report
      2014 Research-status Report
  • [Book] 職業性環境要因とシックハウス症候群・化学物質過敏症2014

    • Author(s)
      坂部 貢
    • Publisher
      北陵館
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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