Basic researches for analysis of mechanism and development of prediction and prevention on arsenic-mediated skin cancer

• Project/Area Number: 25340052
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Nagoya University
• Principal Investigator: Yajima Ichiro 名古屋大学, 医学系研究科, 講師 (80469022)
• Co-Investigator(Kenkyū-buntansha): 武田 湖州恵 中部大学, 生命健康科学部, 准教授 (80345884)
• Co-Investigator(Renkei-kenkyūsha): KATO Masashi 名古屋大学, 大学院医学系研究科, 教授 (10281073)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ヒ素 / 重金属 / 発癌 / 皮膚癌 / 井戸水 / 皮膚 / 毒性

Outline of Final Research Achievements

Since two hundred millions people are using arsenic-polluted well water for drinking, a large number of people develop arsenic poisoning including skin cancer and neural diseases. Although it is a vitally important problem in the world, there is no effective method for prediction, prevention, diagnosis and therapy. Our fieldwork analysis on arsenic-polluted area in Bangladesh and experimental analysis in our laboratory found that the amount of Placental Growth Factor (PlGF) protein was increased in urine of people who are drinking arsenic-polluted well water and also elucidated the mechanism of arsenic-mediated skin cancer development via PlGF.

Research Products

• [Journal Article] Transcription factor LSF (TFCP2) inhibits melanoma growth. (2016)
  • Author(s): Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki T, Inoue Y, Fukushima S, Ihn H, Kyoya M, Ohashi H, Kawakami T, Bennett DC, Kato M.
  • Journal Title: Oncotarget. Volume: 19 Issue: 3 Pages: 2739-2790
  • DOI: 10.18632/oncotarget.6230
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decreased expression levels of cell cycle regulators and matrix metalloproteinases in melanoma from RET-transgenic mice by single irradiation of non-equilibrium atmospheric pressure plasmas (2015)
  • Author(s): Iida, M. Omata, Y. Nakano, C. Yajima, I. Tsuzuki, T. Ishikawa, K. Hori, M. Kato, M.
  • Journal Title: Int J Clin Exp Pathol Volume: 8 Pages: 9326-9331
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Correlated expression levels of endothelin receptor B and Plexin C1 in melanoma (2015)
  • Author(s): Kumasaka, M. Y. Yajima, I. Iida, M. Takahashi, H. Inoue, Y. Fukushima, S. Ihn, H. Takeda, K. Naito, Y. Yoshikawa, T. Kato, M.
  • Journal Title: Am J Cancer Res Volume: 5 Pages: 1117-1123
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epidemiological analysis of the association between hearing and barium in humans (2015)
  • Author(s): Ohgami, N. Mitsumatsu, Y. Ahsan, N. Akhand, A. A. Li, X. Iida, M. Yajima, I. Naito, M. Wakai, K. Ohnuma, S. Kato, M.
  • Journal Title: J Expo Sci Environ Epidemiol Volume: - Issue: 5 Pages: 488-493
  • DOI: 10.1038/jes.2015.62
  • NAID: 120005851029
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Carcinogenic risk of chromium, copper and arsenic in CCA-treated woods. (2015)
  • Author(s): Ohgami N, Yamanoshita O, Thang ND, Yajima I, Nakano C, Wu W, Ohnuma S, Kato M.
  • Journal Title: Environ Pollut Volume: 206 Pages: 456-460
  • DOI: 10.1016/j.envpol.2015.07.041
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Arsenic-mediated promotion of anchorage-independent growth through increased level of placental growth factor. (2015)
  • Author(s): Yajima I, Kumasaka MY, Ohnuma S, Ohgami N, Naito H, Shekhar HU, Omata Y, Kato M.
  • Journal Title: J Invest Dermatol Volume: 135 Issue: 4 Pages: 1147-1156
  • DOI: 10.1038/jid.2014.514
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice. (2014)
  • Author(s): Iida M,Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M.
  • Journal Title: Eur J Dermatol Volume: 24 Issue: 3 Pages: 392-394
  • DOI: 10.1684/ejd.2014.2330
  • Peer Reviewed / Open Access
• [Journal Article] Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma. (2014)
  • Author(s): Omata Y, Iida M, Yajima I, Takeda K, Ohgami N, Masaru Hori H, Kato M.
  • Journal Title: Environ Health Prev Med. Volume: 19 Issue: 5 Pages: 367-369
  • DOI: 10.1007/s12199-014-0399-1
  • NAID: 50009312844
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma. (2014)
  • Author(s): Thang ND, Yajima I, Kumasaka MY, Kato M.
  • Journal Title: PLoS One Volume: 9 Issue: 5 Pages: e96945-e96945
  • DOI: 10.1371/journal.pone.0096945
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice. (2014)
  • Author(s): Yajima I, Iida M, Kumasaka MY, Omata Y, Ohgami N, Chang J, Ichihara S, Hori M, Kato M.
  • Journal Title: Exp Dermatol Volume: 23 Issue: 6 Pages: 424-425
  • DOI: 10.1111/exd.12415
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An actin-binding protein Espin is a novel growth regulator for melanoma. (2014)
  • Author(s): Yanagishita T, Yajima I, Kumasaka MY, Iida M, Xiang L, Tamada Y, Mtsuoto Y, Watabnabe D, Kato M.
  • Journal Title: J Invest Dermatol Volume: 134 Issue: 12 Pages: 2996-2999
  • DOI: 10.1038/jid.2014.249
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Commentary to Krishna et al. (2014): Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water. (2014)
  • Author(s): Kumasaka MY, Yajima I, Ohgami N, Naito H, Omata Y, Kato M
  • Journal Title: Arch Toxicol Volume: -
• [Journal Article] Actin-binding Protein, Espin : a Novel Metastatic Regulator for Melanoma. (2013)
  • Author(s): Yanagishita T, Yajima I, Kumasaka MY, Kawamoto Y, Tsuzuki T, Matsumoto Y, Watanabe D and Kato M.
  • Journal Title: Molecular Cancer Research Volume: 12 Issue: 3 Pages: 1-7
  • DOI: 10.1158/1541-7786.mcr-13-0468-t
  • Peer Reviewed
• [Presentation] ヒ素曝露によって誘発される皮膚癌発症機構と 新たなバイオマーカーに関する解析 (2015)
  • Author(s): 矢嶋伊知朗、大神信孝、飯田真智子、加藤昌志
  • Organizer: 第88回日本産業衛生学会学術総会
  • Place of Presentation: グランフロント大阪（大阪市北区大深町3-1）
  • Year and Date: 2015-05-13