Development of evaluation method for immunotoxicity of air pollultant chemical using human peripheral blood and cultured cell

• Project/Area Number: 25340056
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental impact assessment
• Research Institution: Nagoya University (2014-2015); Kanazawa University (2013)
• Principal Investigator: HORII Masae 名古屋大学, 環境学研究科, 研究員 (50644259)
• Co-Investigator(Kenkyū-buntansha): KAMBAYASHI Yasuhiro 金沢大学, 医学系, 講師 (20345630) ; NAKAMURA Hiroyuki 金沢大学, 医学系, 教授 (30231476) ; HITOMI Yoshiaki 金沢大学, 医学系, 教授 (70231545)
• Research Collaborator: IWAUCHI Yoko 金沢大学, 医学系, 技能補佐員
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 化学物質の健康影響 / アレルギー

Outline of Final Research Achievements

Recently, exacerbation of asthma and allergic rhinitis due to air pollution has reported using epidemiologic data and animal experiments. It is possible that chemicals contained in air pollution modify allergen (ex. pollen, mite) to enhance antigenicity, or affect cells involved in allergy. In this research, we tried to develop a convenient method to estimate these exacerbation of allergy on personal level using peripheral human blood.

Research Products

• [Journal Article] A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism (2016)
  • Author(s): Thao Thi Thu Nguyen , Tomomi Higashi , Yasuhiro Kambayashi , Enoch Olando Anyenda , Yoshimasa Michigami , Johsuke Hara , Masaki Fujimura , Hiromasa Tsujiguchi , Masami Kitaoka , Hiroki Asakura , Daisuke Hori , Yuri Hibino, Tadashi Konoshita and Hiroyuki Nakamura
  • Journal Title: Int. J. Environ. Res. Public Health Volume: 13 Issue: 1 Pages: 110-123
  • DOI: 10.3390/ijerph13010110
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study. (2014)
  • Author(s): Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakai S, Honda Y, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Anyenda EO, Hitomi Y, Nakamura H.
  • Journal Title: Atmospheric Environment Volume: 92 Pages: 506-513
  • DOI: 10.1016/j.atmosenv.2014.04.034
  • NAID: 120005463354
  • Peer Reviewed / Open Access
• [Journal Article] 黄砂とアレルギー疾患 (2014)
  • Author(s): 東朋美, 神林康弘, 藤村政樹, 大倉徳幸, 吉崎智一, 中西清香, 西條清史, 早川和一, 小林史尚, 道上義正, 人見嘉哲, 中村裕之
  • Journal Title: エアロゾル研究 Volume: 29（S1) Pages: 212-217
  • NAID: 130003393430
  • Peer Reviewed
• [Journal Article] Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa (2014)
  • Author(s): Tomomi Higashi, Yasuhiro Kambayashi, Noriyuki Ohkura, Masaki Fujimura, Sayaka Nakanishi, Tomokazu Yoshizaki, Kiyofumi Saijoh, Kazuichi Hayakawa, Fumihisa Kobayashi, Yoshimasa Michigami, Yoshiaki Hitomi, Hiroyuki Nakamura
  • Journal Title: Atmospheric Environment Volume: in press
  • NAID: 120005418493
  • Peer Reviewed
• [Presentation] 大気粒子状物質中PAHやSO2と成人慢性咳嗽患者における咳症状との関連 (2015)
  • Author(s): Anyenda Enoch Oland, 神林康弘、東朋美、Ngueyn Thi Thu Thao、道上義正、他
  • Organizer: 第13回日本予防医学会学術総会
  • Place of Presentation: フレンドパーク石川(石川県金沢市））
  • Year and Date: 2015-06-20
• [Presentation] 慢性咳嗽患者における重金属と目のかゆみと咳の関連 IgEレベルによる違い (2015)
  • Author(s): Nguyen Thi Thu Tha、神林康弘、東朋美、Anyenda Enoch Olando、道上義正、他
  • Organizer: 第13回日本予防医学会学術総会
  • Place of Presentation: フレンドパーク石川（石川県金沢市）
  • Year and Date: 2015-06-20
• [Presentation] 越境大気汚染の慢性咳嗽への影響評価 (2014)
  • Author(s): 東朋美，神林康弘，藤村政樹，早川和一，西條清史，杉本伸夫，中井里史，本田靖，小林史尚，人見嘉哲，中村裕之
  • Organizer: 第55回大気環境学会年会 健康・影響分科会「越境大気汚染の健康影響評価とその課題」
  • Place of Presentation: 愛媛
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] 黄砂と慢性咳嗽に関する臨床疫学 (2014)
  • Author(s): 東朋美，神林康弘，藤村正樹，西條清史，早川和一，杉本伸夫，中井里史，本田靖，人見嘉哲
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山
  • Year and Date: 2014-05-25 – 2014-05-27
• [Presentation] アスピリンが好塩基球のIgE依存的活性化に及ぼす影響 (2013)
  • Author(s): 堀井雅恵, 福冨友馬, 東馬智子, 東朋美, 北岡政美, 三苫純子, 朝倉大貴, 神林康弘, 人見嘉哲, 谷内江昭宏, 中村裕之
  • Organizer: 第20回日本免疫毒性学会学術大会
  • Place of Presentation: 東海大学代々木キャンパス