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Development of evaluation method for immunotoxicity of air pollultant chemical using human peripheral blood and cultured cell

Research Project

Project/Area Number 25340056
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental impact assessment
Research InstitutionNagoya University (2014-2015)
Kanazawa University (2013)

Principal Investigator

HORII Masae  名古屋大学, 環境学研究科, 研究員 (50644259)

Co-Investigator(Kenkyū-buntansha) KAMBAYASHI Yasuhiro  金沢大学, 医学系, 講師 (20345630)
NAKAMURA Hiroyuki  金沢大学, 医学系, 教授 (30231476)
HITOMI Yoshiaki  金沢大学, 医学系, 教授 (70231545)
Research Collaborator IWAUCHI Yoko  金沢大学, 医学系, 技能補佐員
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords化学物質の健康影響 / アレルギー
Outline of Final Research Achievements

Recently, exacerbation of asthma and allergic rhinitis due to air pollution has reported using epidemiologic data and animal experiments. It is possible that chemicals contained in air pollution modify allergen (ex. pollen, mite) to enhance antigenicity, or affect cells involved in allergy. In this research, we tried to develop a convenient method to estimate these exacerbation of allergy on personal level using peripheral human blood.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2016 2015 2014 2013

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (5 results)

  • [Journal Article] A Longitudinal Study of Association between Heavy Metals and Itchy Eyes, Coughing in Chronic Cough Patients: Related with Non-Immunoglobulin E Mediated Mechanism2016

    • Author(s)
      Thao Thi Thu Nguyen , Tomomi Higashi , Yasuhiro Kambayashi , Enoch Olando Anyenda , Yoshimasa Michigami , Johsuke Hara , Masaki Fujimura , Hiromasa Tsujiguchi , Masami Kitaoka , Hiroki Asakura , Daisuke Hori , Yuri Hibino, Tadashi Konoshita and Hiroyuki Nakamura
    • Journal Title

      Int. J. Environ. Res. Public Health

      Volume: 13 Issue: 1 Pages: 110-123

    • DOI

      10.3390/ijerph13010110

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study.2014

    • Author(s)
      Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakai S, Honda Y, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Anyenda EO, Hitomi Y, Nakamura H.
    • Journal Title

      Atmospheric Environment

      Volume: 92 Pages: 506-513

    • DOI

      10.1016/j.atmosenv.2014.04.034

    • NAID

      120005463354

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 黄砂とアレルギー疾患2014

    • Author(s)
      東朋美, 神林康弘, 藤村政樹, 大倉徳幸, 吉崎智一, 中西清香, 西條清史, 早川和一, 小林史尚, 道上義正, 人見嘉哲, 中村裕之
    • Journal Title

      エアロゾル研究

      Volume: 29(S1) Pages: 212-217

    • NAID

      130003393430

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian dust: A hospital-based study in Kanazawa2014

    • Author(s)
      Tomomi Higashi, Yasuhiro Kambayashi, Noriyuki Ohkura, Masaki Fujimura, Sayaka Nakanishi, Tomokazu Yoshizaki, Kiyofumi Saijoh, Kazuichi Hayakawa, Fumihisa Kobayashi, Yoshimasa Michigami, Yoshiaki Hitomi, Hiroyuki Nakamura
    • Journal Title

      Atmospheric Environment

      Volume: in press

    • NAID

      120005418493

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 大気粒子状物質中PAHやSO2と成人慢性咳嗽患者における咳症状との関連2015

    • Author(s)
      Anyenda Enoch Oland, 神林康弘、東朋美、Ngueyn Thi Thu Thao、道上義正、他
    • Organizer
      第13回日本予防医学会学術総会
    • Place of Presentation
      フレンドパーク石川(石川県金沢市))
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 慢性咳嗽患者における重金属と目のかゆみと咳の関連 IgEレベルによる違い2015

    • Author(s)
      Nguyen Thi Thu Tha、神林康弘、東朋美、Anyenda Enoch Olando、道上義正、他
    • Organizer
      第13回日本予防医学会学術総会
    • Place of Presentation
      フレンドパーク石川(石川県金沢市)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 越境大気汚染の慢性咳嗽への影響評価2014

    • Author(s)
      東朋美,神林康弘,藤村政樹,早川和一,西條清史,杉本伸夫,中井里史,本田靖,小林史尚,人見嘉哲,中村裕之
    • Organizer
      第55回大気環境学会年会 健康・影響分科会「越境大気汚染の健康影響評価とその課題」
    • Place of Presentation
      愛媛
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 黄砂と慢性咳嗽に関する臨床疫学2014

    • Author(s)
      東朋美,神林康弘,藤村正樹,西條清史,早川和一,杉本伸夫,中井里史,本田靖,人見嘉哲
    • Organizer
      第84回日本衛生学会学術総会
    • Place of Presentation
      岡山
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Research-status Report
  • [Presentation] アスピリンが好塩基球のIgE依存的活性化に及ぼす影響2013

    • Author(s)
      堀井雅恵, 福冨友馬, 東馬智子, 東朋美, 北岡政美, 三苫純子, 朝倉大貴, 神林康弘, 人見嘉哲, 谷内江昭宏, 中村裕之
    • Organizer
      第20回日本免疫毒性学会学術大会
    • Place of Presentation
      東海大学代々木キャンパス
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2025-11-19  

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