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Establishment of neonatal animal model for early detection of environmental pollutant induced-learning disability

Research Project

Project/Area Number 25340066
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental impact assessment
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

Win-Shwe Tin-Tin  国立研究開発法人国立環境研究所, 環境健康研究センター, 主任研究員 (00391128)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経毒性 / 学習行動 / 新生児モデル / 環境汚物質 / マウス / 学習・記憶 / 行動 / 新生児 / 脳 / 早期検診 / 環境汚染物質 / 嗅球 / バイマーカー
Outline of Final Research Achievements

We have established a novel olfactory-based spatial learning test and examined the effects of exposure to nano-sized diesel exhaust-origin secondary organic aerosol (SOA) on the learning performance in preweaning mice. Pregnant BALB/c mice were exposed to clean air, diesel exhaust (DE), or DE-origin SOA (DE-SOA) from gestational day 14 to postnatal day (PND) 10 in exposure chambers. On PND 11, the mice were examined by the olfactory-based spatial learning test. The mice exposed to DE or DE-SOA took a longer time to reach the target as compared to the control mice. N-methyl-D-aspartate (NMDA) receptor subunits NR1 and NR2B, and immunological markers such as TNF-α, COX2, and Iba1 mRNAs were significantly increased in the hippocampi of the DE-SOA-exposed preweaning mice as compared to the control mice. Our results indicate that DE-SOA exposure during developmental period may affect the olfactory-based spatial learning behavior in preweaning mice.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Exposure of BALB/c Mice to Diesel Engine Exhaust Origin Secondary Organic Aerosol (DE-SOA) during the Developmental Stages Impairs the Social Behavior in Adult Life of the Males2016

    • Author(s)
      Tin-Tin Win-Shwe, Chaw Kyi-Tha-Thu, Yadanar Moe, Yuji Fujitani, Shinji Tsukahara, Seishiro Hirano
    • Journal Title

      Front. Neurosci.

      Volume: 9 Pages: 524-524

    • DOI

      10.3389/fnins.2015.00524

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Nano-Sized Secondary Organic Aerosol of Diesel Engine Exhaust Origin Impairs Olfactory-Based Spatial Learning Performance in Preweaning Mice2015

    • Author(s)
      Tin-Tin Win-Shwe, Chaw Kyi-Tha-Thu, Yadanar Moe, Fumihiko Maekawa, Rie Yanagisawa, Akiko Furuyama, Shinji Tsukahara, Yuji Fujitani, Seishiro Hirano
    • Journal Title

      Nanomaterials

      Volume: 5 Issue: 3 Pages: 1147-1162

    • DOI

      10.3390/nano5031147

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Novel approach to olfactory-based spatial learning ability for prewearning mice and the effects of early exposure to diesel exhaust origin secondary organic aerosol.2016

    • Author(s)
      Tin-Tin Win-Shwe, Chaw Kyi-Tha-Thu, Yadanar Moe, Yuji Fujitani, Shinji Tsukahara, Fumihiko Maekawa, Seishiro Hirano
    • Organizer
      44th myanmar health research congress
    • Place of Presentation
      ミャンマー医学研究センター(ヤンゴン・ミャンマー)
    • Year and Date
      2016-01-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of an olfactory-based spatial learning test for preweaning mice and the ef-fects of early exposure to diesel exhaust origin secondary organic aerosol2015

    • Author(s)
      Tin-Tin Win-Shwe, Chaw Kyi-Tha Thu, Yadanar Moe, Fujitani Y.(藤谷雄二), Shinji Tsukahara, Nitta H.(新田裕史), Hirano S.(平野靖史郎)
    • Organizer
      51st Congress of the European Societies of Toxicology
    • Place of Presentation
      Port (ポルトガル)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diesel engine exhaust origin secondary organic aerosol affects olfactory-based spatial learning performance and related gene expressions in preweaning mice2015

    • Author(s)
      Tin-Tin Win-Shwe, 藤谷雄二, 野原恵子, 平野靖史郎
    • Organizer
      第4回日本DOHaD研究会学術集会
    • Place of Presentation
      昭和大学(東京都品川区)
    • Year and Date
      2015-08-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Developmental exposure to diesel engine exhaust origin secondary organic aerosol on olfactory-based spatial learning performance in preweaning mice2015

    • Author(s)
      Tin-Tin Win-Shwe, Yuji Fujitani, Akiko Furuyama, Hiroshi Nitta, Seishiro Hirano
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際展示場(神戸)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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