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Study on suppressing the biodegradability of biodegradable polymers

Research Project

Project/Area Number 25340097
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Environmental conscious materials and recycle
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

YAMANO Naoko  国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (20358279)

Co-Investigator(Kenkyū-buntansha) 中山 敦好  国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (10357676)
川崎 典起  国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (70344158)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生分解性材料 / 生分解性制御 / バイオベース / ポリアミド / 生分解性ポリマー / 疎水性
Outline of Final Research Achievements

Biodegradable polymers have been developed as green materials. However, when they are used for a long time, long-term stability is important and biodegradability is undesired. Polyamide 4 (PA4) is a biodegradable polymer that can be produced from biomass. Various functional groups were introduced to biodegradable polymers (PA4 and PCL). Hydrophobic groups like long-chain fatty acid as a terminal group suppressed biodegradability of polymers. Adding hydrophilicity with methylolation accelerated biodegradation even if the polymer suppressed biodegradability by long-chain fatty acid terminal. The alteration of the hydrophobicity of the polymers was directly related to the suppression of the biodegradability. Polymers that suppressed biodegradability degraded with surfactants.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (23 results)

All 2017 2016 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 3 results) Presentation (16 results) (of which Invited: 3 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Biodegradation of polyamide 4 in vivo2017

    • Author(s)
      Naoko YAMANO, Norioki KAWASAKI, Sayuri IDA, Yasuhide NAKAYAMA, Atsuyoshi NAKAYAMA
    • Journal Title

      Polymer Degradation and Stability

      Volume: 137 Pages: 281-288

    • DOI

      10.1016/j.polymdegradstab.2017.02.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Polyamide4-block-poly(vinyl acetate) via a polyamide4 azo macromolecular initiator: Thermal and mechanical behavior, biodegradation, and morphology2015

    • Author(s)
      Norioki Kawasaki, Naoko Yamano, Atsuyoshi Nakayama
    • Journal Title

      Journal of applied polymer science

      Volume: 132 Issue: 37

    • DOI

      10.1002/app.42466

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biodegradation of a poly(ε-caprolactone-co-L-lactide)-visible-light-sensitive TiO2 composite with an on/off biodegradation function2015

    • Author(s)
      H.Ando, N.Kawasaki, N.Yamano, K.Uegaki, A.Nakayama
    • Journal Title

      Polymer Degradation and Stability

      Volume: 114 Pages: 65-71

    • DOI

      10.1016/j.polymdegradstab.2015.02.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polyamide 4 with long-chain fatty acid groups e Suppressing the biodegradability of biodegradable polymers2014

    • Author(s)
      N. Yamano, N. Kawasaki, M. Oshima, A. Nakayama
    • Journal Title

      Polymer Degradation and Stability

      Volume: 108 Pages: 116-122

    • DOI

      10.1016/j.polymdegradstab.2014.06.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ポリアミド4の各種環境での生分解2016

    • Author(s)
      山野尚子、川崎典起、中山敦好
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] バイオ材料への応用を目指したポリアミド42016

    • Author(s)
      川崎 典起 山野 尚子 中山 敦好
    • Organizer
      JST産総研新技術説明会
    • Place of Presentation
      JST東京本部別館1Fホール(東京都)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生分解性を持つバイオベースポリマー:ポリアミド42016

    • Author(s)
      山野尚子、川崎典起、中山敦好
    • Organizer
      第5回JACI/GSCシンポジウム
    • Place of Presentation
      ANAクラウンプラザホテル神戸(神戸市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポリアミド4-6共重合体の合成、物性、生分解性2016

    • Author(s)
      川崎 典起 山野 尚子 中山 敦好
    • Organizer
      第5回JACI/GSCシンポジウム
    • Place of Presentation
      ANAクラウンプラザホテル神戸(神戸市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生分解性ポリマーの修飾による生分解性の制御2015

    • Author(s)
      山野尚子、川崎典起、中山敦好
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] ポリアミド4-block-ポリ酢酸ビニルの合成と物性2015

    • Author(s)
      川崎典起、山野尚子、中山敦好、上垣浩一
    • Organizer
      第64回高分子学会年次大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2015-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] コポリ(L-乳酸/グリコール酸)のステレオコンプレックスの生分解性2015

    • Author(s)
      中山敦好、川崎典起、山野尚子、上垣浩一
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 生分解のON/OFFを切り替え可能にしたポリマー系ナノコンポジットの開発2015

    • Author(s)
      安藤仁、中山敦好、山野尚子、川崎典起、上垣浩一
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山大学
    • Year and Date
      2015-03-27 – 2015-03-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 生分解性材料であるポリアミド4の生体内分解性と安全性評価2014

    • Author(s)
      山野尚子、川崎典起、中山敦好
    • Organizer
      高分子討論会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Biodegradation and stability of biobased polyamide 42014

    • Author(s)
      中山敦好、川崎典起、山野尚子、中村努、上垣浩一
    • Organizer
      International Synposium for Green-Innovation Polymers
    • Place of Presentation
      近江町交流プラザ(金沢市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ポリ乳酸コポリマーステレオコンプレックスの生分解2014

    • Author(s)
      中山敦好、川崎典起、山野尚子、上垣浩一
    • Organizer
      日本農芸化学会2014大会
    • Place of Presentation
      明治大学(川崎市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 生分解性ポリマーの生分解性制御2014

    • Author(s)
      山野尚子、川崎典起、中山敦好
    • Organizer
      日本農芸化学会2014大会
    • Place of Presentation
      明治大学(川崎市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ポリアミド4の生分解とその制御2013

    • Author(s)
      山野尚子、川崎典起、中山敦好
    • Organizer
      第二回JACI/GSCシンポジウム
    • Place of Presentation
      メルパルク大阪(大阪市)
    • Related Report
      2013 Research-status Report
  • [Presentation] ポリアミド系コポリマーの生分解性2013

    • Author(s)
      中山敦好、川崎典起、山野尚子
    • Organizer
      第二回JACI/GSCシンポジウム
    • Place of Presentation
      メルパルク大阪(大阪市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 2-ピロリドンを含むコポリエステルアミドの生分解2013

    • Author(s)
      中山敦好、川崎典起、山野尚子、上垣浩一、田所美香、弓場俊輔
    • Organizer
      第62回高分子討論会
    • Place of Presentation
      金沢大学(金沢市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Control of biodegradation of polyesters2013

    • Author(s)
      中山敦好、川崎典起、山野尚子
    • Organizer
      4th International Conference on Biobased Polymers
    • Place of Presentation
      Hangyang Institute of Technology(ソウル、韓国)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 医療用バイオベースマテリアル2015

    • Author(s)
      中山敦好、川崎典起、山野尚子
    • Total Pages
      6
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] ポリアミド4またはその共重合体を含む医療材料及び使用2014

    • Inventor(s)
      山野尚子、川崎典起、中山敦好
    • Industrial Property Rights Holder
      山野尚子、川崎典起、中山敦好
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-164681
    • Filing Date
      2014-08-13
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 生分解性樹脂の樹脂組成物、分解制御方法及び分解制御剤2014

    • Inventor(s)
      安藤仁、中山敦好、山野尚子、川崎典起、上垣浩一、黒田靖
    • Industrial Property Rights Holder
      安藤仁、中山敦好、山野尚子、川崎典起、上垣浩一、黒田靖
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-179975
    • Filing Date
      2014-09-04
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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