| Project/Area Number |
25340102
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental risk control and evaluation
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| Research Institution | Azabu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 消毒剤 / 土壌 / 副生成物質 / 変異原性 / 消長 / 副生成物 / アルカリ系消毒薬 / 塩素系消毒薬 / 複合製剤 / microsuspension法 |
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| Outline of Final Research Achievements |
The impact on the soil environment of disinfectants used in dairy-related facilities for preventing the spread of infections has been examined. Several soil samples were collected from surrounding area. Disinfectants containing chlorine, alkaline disinfectants, and combination drugs, were sprayed on these soil samples. Organic matter in the soil disinfectant reactant compounds was extracted by the ultrasonic extraction method, using 7 organic solvents respectively. As a result, high mutagenic activity such as acetone was detected of in several solvent extracts to chlorine-based disinfectants. And there were many cases of direct acting mutagens causing base pair changes. Mutagenic by-products in soil tend to decrease over time, so even the particularly high mutagenic activities was reduced by more than about 80% after 1 year. The products were analyzed using a GC-MS, which suggested that several chemicals showing mutagenicity such benzaldehyde were present.
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