| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Murine contact hypersensitivity (CHS) is one of the most frequently used animal models of human allergic contact dermatitis (ACD). In this study, we investigated the inhibitory effects of diets supplemented with pomegranate polyphenol concentrate (PPC) on CHS. The results indicate that low doses of dietary PPC alleviate CHS symptoms by attenuating inflammation via downregulation of CXCL2 and CCL12, suggesting that dietary supplementation with PPC may provide beneficial effects on ACD at physiologically relevant doses to humans. Furthermore, it is suggested that the synergically inhibitory effects of PPC and soybean isoflavone on CHS.
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