| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Protocatechuic acid (PCA) is a degraded product derived from cyanidin-3-glucoside (C3G) during thermal cooking. In this study, the inhibitory effect of antioxidant activity of PCA was compared with C3G in vivo. Moreover, the effect of dietary purple-black rice on hyperlipidemia was examined in high-cholesterol and high-fat diet-fed mice. The thiobarbituric acid reactive substances levels of plasma and the renal homogenate were lower in mice administered PCA before the induction of oxidative stress with ions than that in mice administered C3G. Dietary purple-black rice led to increased HDL-cholesterol concentration in the plasma of mice. Furthermore, the improvement effect was higher in the cooked rice than that in the uncooked rice.These findings suggest that purple-black rice likely suppresses plasma lipid metabolism abnormalities. One of the probable reasons for this effective suppression by heating is the superior antioxidant properties of PCA, compared to C3G.
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