The elucidation of the neurophysiology mechanism after the GABA intake in human using cross-correlation and coherence analysis

• Project/Area Number: 25350123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Shizuoka University
• Principal Investigator: OKITA YOSHIMITSU 静岡大学, 工学部, 講師 (60270310)
• Co-Investigator(Kenkyū-buntansha): 中村 晴信 神戸大学, 人間発達環境学研究科, 教授 (10322140) ; 杉浦 敏文 静岡大学, 電子工学研究所, 教授 (20135239)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: GABA / 機能性食品 / 自律神経活動 / 中枢神経活動

Outline of Final Research Achievements

It has been reported that a mechanism of anti-stress effect induced by GABA intake is involved central nervous and autonomic nervous systems. A mutual mechanism of these nervous systems is not clear. The purpose of this study is to clarify the mutual mechanism of these nervous systems using cross-correlation and coherence analysis. The results suggest that there is an intimate association between central nervous (delta activity in the frontal area: alpha activity in the central, parietal and temporal areas: beta activity in the occipital area) and autonomic nervous systems (ECG) after intake of GABA.

Research Products

• [Journal Article] An Assessment Tool for Effective Monitoring of Autonomic Nervous System Activity in Healthy People (2014)
  • Author(s): T.Yanagida, Y.Okita, H.Nakamura, T.Sugiura, H.Mimura
  • Journal Title: Journal of Advanced Computational Intelligence and Intelligent Informatics Volume: Vol.18 Pages: 297-304
  • NAID: 130007673122
  • Peer Reviewed
• [Presentation] システム開発ソフトウェアを用いた心電図及び胃電図の同時計測及び解析装置の開発 (2016)
  • Author(s): 沖田善光, 小原久未子, 高橋勲, 木村元彦, 杉浦敏文, 中村晴信
  • Organizer: 第70回日本栄養・食糧学会大会(国内学会)
  • Place of Presentation: 武庫川女子大学（兵庫県・西宮市）
  • Year and Date: 2016-05-13
• [Presentation] 天然食品（GABA含有）摂取時の血漿GABA濃度と自律神経活動との時間的関係－3名の症例研究から－ (2016)
  • Author(s): 大橋和義, 沖田善光, 甲田勝康, 高橋勲, 木村元彦, 杉浦敏文, 中村晴信
  • Organizer: 第70回日本栄養・食糧学会大会(国内学会)
  • Place of Presentation: 武庫川女子大学（兵庫県・西宮市）
  • Year and Date: 2016-05-13
• [Presentation] Development of Systems for Simultaneous Measuring and Analyzing Electrocardiogram and Electrogastrography using a System Developlemt Software (2015)
  • Author(s): Y.Okita, K.Ohara, K.Ishihara, Y.Taira, M.Takaoka, M.Kimura, T.Sugiura, H.Nakamura
  • Organizer: 12th International Congress of Physiological Anthropology (ICPA2015)
  • Place of Presentation: 東京ベイ幕張(千葉県・千葉市)
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] Development of systems for measuring and analyzing electrocardiogram and heart rate variability using a system developlemt software (2015)
  • Author(s): Y.Okita, K.Ohara, K.Ishihara, Y.Taira, M.Takaoka, M.Kimura, T.Sugiura, H.Nakamura
  • Organizer: 12th Asian Congress of Nutrition (ACN2015)
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Individual response of the autonomic nervous system to the green odor of young barley grass extract (2015)
  • Author(s): Y.Aotsuka, Y.Okita, M.Ukeguchi, I.Takahashi, M.Kimura, T.Sugiura, H.Nakamura
  • Organizer: 12th Asian Congress of Nutrition (ACN2015)
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] システム開発ソフトウェアを用いた心電図(心拍変動指標)の計測・解析装置の開発 (2014)
  • Author(s): 沖田善光, 石原一彦, 平豊, 高岡素子, 小原久未子, 木村元彦, 杉浦敏文, 中村晴信
  • Organizer: 第71回日本生理人類学会大会
  • Place of Presentation: 神戸大学百年記念館(兵庫県・神戸市)
  • Year and Date: 2014-11-01 – 2014-11-02
• [Presentation] Development of systems for measuring and analyzing autonomic nerve activity using LabView and its application (2014)
  • Author(s): Y.Okita, K.Ishihara, Y.Taira, M.Takaoka, K.Ohara, M.Kimura, T.Sugiura, H.Nakamura
  • Organizer: 17th World Congress of Psychophysiology (IOP2014)
  • Place of Presentation: 広島国際会議場（広島県・広島市）
  • Year and Date: 2014-09-23 – 2014-09-27
• [Presentation] Effects of the smell of young barley grass on autonomic nervous system (2014)
  • Author(s): Y.Aotsuka, Y.Okita, M.Ukeguchi, I.Takahashi, M.Kimura, T.Sugiura, H.Nakamura
  • Organizer: 17th World Congress of Psychophysiology (IOP2014)
  • Place of Presentation: 広島国際会議場（広島県・広島市）
  • Year and Date: 2014-09-23 – 2014-09-27
• [Presentation] Change of instantaneous amplitude of an autonomic nerve activity on a meal pattern by Filter design and Hilbert transform (2013)
  • Author(s): Y.Okita, K.Ohara, I.Takahashi, K.Kouda, T.Sugiura, H.Nakamura
  • Organizer: 13th International Conference of FFC 2013- First International Symposium of ASFFBC 2013
  • Place of Presentation: 京都府立医科大学(京都府)
• [Presentation] Development of Application for Brief Assessment of Autonomic Nervous Activity in Healthy People (2013)
  • Author(s): T.Yanagida, Y.Okita, H.Nakamura, K.Kouda, T.Sugiura, H.Mimura
  • Organizer: 35th Annual International IEEE EMBS Conference 2013
  • Place of Presentation: 大阪府立国際会議場(大阪府)
• [Presentation] 食事パターンに対する自律神経活動の瞬時振幅値の変化について (2013)
  • Author(s): 沖田善光, 小原久未子, 高橋勲, 甲田勝康, 杉浦敏文, 中村晴信
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学(愛知県)
• [Presentation] 日常の生体リズムに対する辛み成分摂取後の長時間の自律神経活動の検討 (2013)
  • Author(s): 大橋和義, 沖田善光, 小原久未子, 中村晴信, 甲田勝康, 木村元彦, 杉浦敏文
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学(愛知県)
• [Presentation] ズーミング・インタフェースによる自律神経活動簡易評価ソフトウェア (2013)
  • Author(s): 柳田拓人, 沖田善光, 中村晴信, 杉浦敏文, 三村秀典
  • Organizer: 第20回日本未病システム学会学術総会
  • Place of Presentation: 学術総合センター(東京都)