Role of dietary ornithine on the regulation of brain function in aged rats

• Project/Area Number: 25350125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Aichi University of Education
• Principal Investigator: HAYASE KAZUTOSHI 愛知教育大学, 教育学部, 教授 (10144180)
• Co-Investigator(Renkei-kenkyūsha): TUJIOKA KAZUYO 桜花学園大学, 保育学部, 准教授 (90440809) ; YOKOGOSHI HIDEHIKO 中部大学, 応用生物学部, 教授 (70109320)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: オルニチン / 脳タンパク質合成 / 成長ホルモン / 脳下垂体摘出 / アルギニン / 神経成長因子 / 転写過程 / ラット / Nerve Growth Factor / RNA activity

Outline of Final Research Achievements

The purpose of present study was to determine the mechanism by which the dietary ornithine affect the brain protein synthesis in aged rats. The protein synthesis rates of brain regions increased significantly in ornithine-treated rats. However, the ornithine injestion did not affect the protein synthesis rates of brain in the hypophysectomized rats. The effect of argine on brain protein synthesis was lower than that of ornithine. The concentration of Nerve Growth Factor (NGF) in the hippocampus were significantly greater in rats fed the ornithie. The level of NGF mRNA in the hippocampus did not differ by the dietary ornithine. The results suggest that the ornithine-induced increase in the concentration of growth hormone may be primarily responsible for changes in the brain protein synthesis. The mRNA level may be not related to the brain protein metabolism when the dietary ornithine is manipulated.

Research Products

• [Presentation] Role of thyroid hormone on the brain protein synthesis in ratas fed the ornithine (2015)
  • Author(s): Kazuyo Tujioka, Takashi Yamada, Hidehiko Yokogoshi, Saori Akiduki, Yukihiro Hishida and Kazutoshi Hayase
  • Organizer: 14th International Congress on Amino Acids, Peptides and Proteins
  • Place of Presentation: ウイ－ン大学（オ－ストリア）
  • Year and Date: 2015-08-03
  • Int'l Joint Research
• [Presentation] Effect of dietary ornithine on the nerve growth factor and the choline acetyltransferase in the brain regions in aged rats (2015)
  • Author(s): Kazuyo Tujioka, Takashi Yamada, Hidehiko Yokogoshi, Saori Akiduki, Yukihiro Hishida and Kazutoshi Hayase
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] オルニチンによる脳タンパク質合成速度の変動におけるアルギニンの役割 (2014)
  • Author(s): 早瀬 和利
  • Organizer: 日本栄養・食糧学会大会
  • Place of Presentation: 酪農学園大学
  • Year and Date: 2014-05-30 – 2014-06-01